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1.
López-Romero E, Reyes-Montes Mdel R, Pérez-Torres A, Ruiz-Baca E, Villagómez-Castro JC, Mora-Montes HM, Flores-Carreón A, Toriello C, 2011. Sporothrix schenckii complex and sporotrichosis, an emerging health problem. Future Microbiol 6: 85–102.
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2.
Carvalho A, Cunha C, Pasqualotto AC, Pitzurra L, Denning DW, Romani L, 2010. Genetic variability of innate immunity impacts human susceptibility to fungal diseases. Int J Infect Dis 14: 460–468.
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3.
Holmberg V, Onkamo P, Lahtela E, Lahermo P, Bedu-Addo G, 2012. Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria. Malar J 11: 61.
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4.
Wallis R, Dodds AW, Mitchell DA, Sim RB, Reid KB, Schwaeble WJ, 2007. Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway. J Biol Chem 282: 7844–7851.
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5.
Fernández-Ruiz M, Giménez E, Lora D, Aguado JM, Pascual M, Manuel O, 2019. Impact of MBL2 gene polymorphisms on the risk of infection in solid organ transplant recipients: a systematic review and meta-analysis. Am J Transplant 19: 1072–1085.
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6.
Kalia N, Singh J, Sharma S, Kaur M, 2019. SNPs in 3′-UTR region of MBL2 increases susceptibility to recurrent vulvovaginal infections by altering sMBL levels. Immunobiology 224: 42–49.
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7.
Beltrame MH, Boldt AB, Catarino SJ, Mendes HC, Boschmann SE, Goeldner I, Messias-Reason I, 2015. MBL-associated serine proteases (MASPs) and infectious diseases. Mol Immunol 67: 85–100.
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8.
Thiel S, Kolev M, Degn S, Steffensen R, Hansen AG, Ruseva M, Jensenius JC, 2009. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol 182: 2939–2947.
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9.
Thiel S, Steffensen R, Christensen I, Ip WK, Lau Y, Reason I, Eiberg H, Gadjeva M, Ruseva M, Jensenius JC, 2007. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun 8: 154–163.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 77 | 77 | 11 |
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| PDF Downloads | 187 | 30 | 1 |
Mannose-Binding Lectin and Mannose-Binding Lectin-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis
Fangfang Bao
Fangfang Bao
Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Xi’an Fu
Xi’an Fu
Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Gongqi Yu
Gongqi Yu
Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Zhenzhen Wang
Zhenzhen Wang
Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Hong Liu
Hong Liu
Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Furen Zhang
Furen Zhang
Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are important proteins in the lectin pathway of the immune system. Mannose-binding lectin and MASP-2 deficiencies have been reported to be responsible for various fungal infections. We investigated the association of MBL and MASP-2 variants with sporotrichosis in a Chinese population and revealed one rare heterozygous mutation in a disseminated cutaneous patient without immunosuppressive conditions (MASP2, p.156_159dupCHNH). We also found that sporotrichosis patients had decreased levels of MBL and MASP-2 in their serum samples compared with controls. Our findings linked, for the first time, MASP-2 deficiencies with susceptibility to Sporothrix sp.
Author Notes
Authors’ addresses: Fangfang Bao, Xi’an Fu, Gongqi Yu, Zhenzhen Wang, Hong Liu, and Furen Zhang, Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China, and Shandong Provincial Key Lab for Dermatovenereology, Jinan, China, E-mails: baofangfang2008@163.com, f19830827@126.com, yugongitje@163.com, zzwang1030@163.com, hongyue2519@hotmail.com, and zhangfuren@hotmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
López-Romero E, Reyes-Montes Mdel R, Pérez-Torres A, Ruiz-Baca E, Villagómez-Castro JC, Mora-Montes HM, Flores-Carreón A, Toriello C, 2011. Sporothrix schenckii complex and sporotrichosis, an emerging health problem. Future Microbiol 6: 85–102.
-
2.
Carvalho A, Cunha C, Pasqualotto AC, Pitzurra L, Denning DW, Romani L, 2010. Genetic variability of innate immunity impacts human susceptibility to fungal diseases. Int J Infect Dis 14: 460–468.
-
3.
Holmberg V, Onkamo P, Lahtela E, Lahermo P, Bedu-Addo G, 2012. Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria. Malar J 11: 61.
-
4.
Wallis R, Dodds AW, Mitchell DA, Sim RB, Reid KB, Schwaeble WJ, 2007. Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway. J Biol Chem 282: 7844–7851.
-
5.
Fernández-Ruiz M, Giménez E, Lora D, Aguado JM, Pascual M, Manuel O, 2019. Impact of MBL2 gene polymorphisms on the risk of infection in solid organ transplant recipients: a systematic review and meta-analysis. Am J Transplant 19: 1072–1085.
-
6.
Kalia N, Singh J, Sharma S, Kaur M, 2019. SNPs in 3′-UTR region of MBL2 increases susceptibility to recurrent vulvovaginal infections by altering sMBL levels. Immunobiology 224: 42–49.
-
7.
Beltrame MH, Boldt AB, Catarino SJ, Mendes HC, Boschmann SE, Goeldner I, Messias-Reason I, 2015. MBL-associated serine proteases (MASPs) and infectious diseases. Mol Immunol 67: 85–100.
-
8.
Thiel S, Kolev M, Degn S, Steffensen R, Hansen AG, Ruseva M, Jensenius JC, 2009. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol 182: 2939–2947.
-
9.
Thiel S, Steffensen R, Christensen I, Ip WK, Lau Y, Reason I, Eiberg H, Gadjeva M, Ruseva M, Jensenius JC, 2007. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun 8: 154–163.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 77 | 77 | 11 |
| Full Text Views | 489 | 122 | 3 |
| PDF Downloads | 187 | 30 | 1 |