Mannose-Binding Lectin and Mannose-Binding Lectin-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis

Fangfang Bao Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China

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Xi’an Fu Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China

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Gongqi Yu Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China

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Zhenzhen Wang Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China

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Hong Liu Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China

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Furen Zhang Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;
Shandong Provincial Key Lab for Dermatovenereology, Jinan, China

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Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are important proteins in the lectin pathway of the immune system. Mannose-binding lectin and MASP-2 deficiencies have been reported to be responsible for various fungal infections. We investigated the association of MBL and MASP-2 variants with sporotrichosis in a Chinese population and revealed one rare heterozygous mutation in a disseminated cutaneous patient without immunosuppressive conditions (MASP2, p.156_159dupCHNH). We also found that sporotrichosis patients had decreased levels of MBL and MASP-2 in their serum samples compared with controls. Our findings linked, for the first time, MASP-2 deficiencies with susceptibility to Sporothrix sp.

Author Notes

Address correspondence to Furen Zhang, Shandong Provincial Institute of Dermatology and Venereology, 27397 Jingshi Rd., Jinan 250022, China. E-mail: zhangfuren@hotmail.com

Authors’ addresses: Fangfang Bao, Xi’an Fu, Gongqi Yu, Zhenzhen Wang, Hong Liu, and Furen Zhang, Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China, and Shandong Provincial Key Lab for Dermatovenereology, Jinan, China, E-mails: baofangfang2008@163.com, f19830827@126.com, yugongitje@163.com, zzwang1030@163.com, hongyue2519@hotmail.com, and zhangfuren@hotmail.com.

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