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Case Report: Paracoccidioidomycosis in Solid Organ Transplantation: Disseminated Disease in a Liver Recipient and Literature Review

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  • 1 Division of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil;
  • | 2 Infectious Diseases Unit, Hospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo, Vitoria, Brazil;
  • | 3 Department of Pathology, Hospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo, Vitoria, Brazil

Paracoccidioidomycosis (PCM) is an endemic systemic mycosis that is of great importance in Latin America. Its occurrence in solid organ transplantation (SOT) is rare, but with high mortality rate. In this report, we describe a case of PCM in a liver transplant recipient 19 months after transplantation. The patient presented with multiple skin abscesses, arthritis, osteolytic lesions, and pulmonary and adrenal involvement. Despite the presence of disseminated disease and the patient’s immunosuppressed condition, the patient responded well to prolonged antifungal treatment with no sequelae, thus suggesting that early diagnosis and correct treatment may lead to favorable outcomes in SOT recipients with PCM.

Author Notes

Address correspondence to Paula M. Peçanha Pietrobom, Division of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Napoleão de Barros 715, São Paulo 04024-002, Brazil. E-mail: paulampecanha@gmail.com

Authors’ addresses: Paula M. Peçanha-Pietrobom, Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, E-mail: paulampecanha@gmail.com. Aloisio Falqueto, Anna Danielle Rodrigues Gandarella, Júlia Vieira Moyzés, Karoline Almeida Rangel, Letícia Balarini Miranda, Matheus Compart Hemerly, and Paulo Mendes Peçanha, Infectious Diseases Unit, Universidade Federal do Espirito Santo, Vitoria, Brazil, E-mails: falqueto@npd.ufes.br, daniellegandarella@gmail.com, julia.moyzes@gmail.com, karoline.a.rangel@gmail.com, lelebalarini@hotmail.com, matheuscompart@hotmail.com, and pmpecanha@uol.com.br. Renata Scarpa Careta, Department of Pathology, Universidade Federal do Espirito Santo, Vitoria, Brazil, E-mail: renatascareta@yahoo.com.br.

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