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-
1.
International Committee on Taxonomy of Viruses (ICTV), 2018. Taxonomy. Available at: https://talk.ictvonline.org/taxonomy/. Accessed February 1, 2019.
-
2.
Yu XJ et al. 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 1523–1532.
-
3.
Hu J et al. 2018. A cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus infection in China, 1996: a retrospective serological study. PLoS Negl Trop Dis 12: e0006603.
-
4.
Kim YR, Yun Y, Bae SG, Park D, Kim S, Lee JM, Cho NH, Kim YS, Lee KH, 2018. Severe fever with thrombocytopenia syndrome virus infection, South Korea, 2010. Emerg Infect Dis 24: 2103–2105.
-
5.
Takahashi T et al. 2014. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209: 816–827.
-
6.
Tran XC, Yun Y, Van An L, Kim SH, Thao NTP, Man PKC, Yoo JR, Heo ST, Cho NH, Lee KH, 2019. Endemic severe fever with thrombocytopenia syndrome in Vietnam. Emerg Infect Dis 25: 1029–1031.
-
7.
Yoo JR, Heo ST, Park D, Kim H, Fukuma A, Fukushi S, Shimojima M, Lee KH, 2016. Family cluster analysis of severe fever with thrombocytopenia syndrome virus infection in Korea. Am J Trop Med Hyg 95: 1351–1357.
-
8.
Wi YM, Woo HI, Park D, Lee KH, Kang CI, Chung DR, Peck KR, Song JH, 2016. Severe fever with thrombocytopenia syndrome in patients suspected of having scrub typhus. Emerg Infect Dis 22: 1992–1995.
-
9.
Yoo JR, Heo ST, Kang JH, Park D, Kim JS, Bae JH, Woo JJ, Kim S, Lee KH, 2018. Mixed infection with severe fever with thrombocytopenia syndrome virus and two genotypes of scrub typhus in a patient, South Korea, 2017. Am J Trop Med Hyg 99: 287–290.
-
10.
Zhang YZ et al. 2012. Hemorrhagic fever caused by a novel bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis 54: 527–533.
-
11.
Yun Y et al. 2015. Phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in South Korea and migratory bird routes between China, South Korea, and Japan. Am J Trop Med Hyg 93: 468–474.
-
12.
Lee YM, Kim DM, Lee SH, Jang MS, Neupane GP, 2011. Phylogenetic analysis of the 56 kDa protein genes of Orientia tsutsugamushi in southwest area of Korea. Am J Trop Med Hyg 84: 250–254.
-
13.
Kim G et al. 2017. Diversification of Orientia tsutsugamushi genotypes by intragenic recombination and their potential expansion in endemic areas. PLoS Negl Trop Dis 11: e0005408.
-
14.
Ha NY, Kim Y, Min CK, Kim HI, Yen NTH, Choi MS, Kang JS, Kim YS, Cho NH, 2017. Longevity of antibody and T-cell responses against outer membrane antigens of Orientia tsutsugamushi in scrub typhus patients. Emerg Microbes Infect 6: e116.
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Severe Fever with Thrombocytopenia Syndrome Virus Infection or Mixed Infection with Scrub Typhus in South Korea in 2000–2003
Nguyen Thi Hai Yen
Nguyen Thi Hai Yen
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Chaewon Kim
Chaewon Kim
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Seonyoung Jeong
Seonyoung Jeong
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Kyeongseok Jeon
Kyeongseok Jeon
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Hooncheol Choi
Hooncheol Choi
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Hyo-Jin Ro
Hyo-Jin Ro
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Hong-Il Kim
Hong-Il Kim
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Yuri Kim
Yuri Kim
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea;
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Jun-Gu Kang
Jun-Gu Kang
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea;
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Dahee Park
Dahee Park
Department of Microbiology and Immunology, College of Medicine, Jeju National University, Jeju, South Korea
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Myung-Sik Choi
Myung-Sik Choi
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
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Keun Hwa Lee
Keun Hwa Lee
Department of Microbiology and Immunology, College of Medicine, Jeju National University, Jeju, South Korea
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Nam-Hyuk Cho
Nam-Hyuk Cho
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea;
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea;
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Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea;
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Severe fever with thrombocytopenia syndrome is a tick-borne viral disease, with a high mortality rate that was first reported in China in 2009. Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi, a bacterium transmitted to humans through chigger mite bites. Severe fever with thrombocytopenia syndrome and scrub typhus are endemic to South Korea. To investigate evidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection or mixed infection with scrub typhus in South Korea, we examined 2,329 sera samples collected from patients presenting from November 1, 2000, to November 1, 2003, for the diagnosis of rickettisal diseases at Seoul National University, Seoul, South Korea. We found retrospective evidence of SFTSV infection or mixed infection with scrub typhus in South Korea in 2000–2003. Severe fever with thrombocytopenia syndrome virus infections in South Korea occurred before previously reported cases and were more concurrent with those in China. It is important to consider SFTSV infection in patients with scrub typhus.
Author Notes
Financial support: This work was supported by a grant from the National Research Foundation of Korea (grant number: 2017M3A9E4061998) and the Korean Health Technology R&D Project of the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C2891). NTHY, CK, KJ, HC, HJR, H-IK, YK, and JGK received a scholarship from the BK21-plus education program provided by the National Research Foundation of Korea.
Authors’ addresses: Nguyen Thi Hai Yen, Chaewon Kim, Seonyoung Jeong, Kyeongseok Jeon, Hooncheol Choi, Hyo-Jin Ro, Hong-Il Kim, Yuri Kim, Myung-Sik Choi, and Nam-Hyuk Cho, Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea, E-mails: nguyenthihaiyenktyh@gmail.com, zzae_1@snu.ac.kr, syjeong02@snu.ac.kr, jkyeong26@snu.ac.kr, hoonchul46@snu.ac.kr, hyojin622@snu.ac.kr, oneperson18@snu.ac.kr, tkarkrwja62@snu.ac.kr, myung@snu.ac.kr, and chonh@snu.ac.kr. Jun-Gu Kang, Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea, E-mail: herculess@snu.ac.kr. Dahee Park and Keun Hwa Lee, Department of Microbiology and Immunology, School of Medicine, Jeju National University, Jeju, South Korea, E-mails: archons1004@naver.com and yomust7@jejunu.ac.kr.
These authors contributed equally to this work.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
International Committee on Taxonomy of Viruses (ICTV), 2018. Taxonomy. Available at: https://talk.ictvonline.org/taxonomy/. Accessed February 1, 2019.
-
2.
Yu XJ et al. 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 1523–1532.
-
3.
Hu J et al. 2018. A cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus infection in China, 1996: a retrospective serological study. PLoS Negl Trop Dis 12: e0006603.
-
4.
Kim YR, Yun Y, Bae SG, Park D, Kim S, Lee JM, Cho NH, Kim YS, Lee KH, 2018. Severe fever with thrombocytopenia syndrome virus infection, South Korea, 2010. Emerg Infect Dis 24: 2103–2105.
-
5.
Takahashi T et al. 2014. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209: 816–827.
-
6.
Tran XC, Yun Y, Van An L, Kim SH, Thao NTP, Man PKC, Yoo JR, Heo ST, Cho NH, Lee KH, 2019. Endemic severe fever with thrombocytopenia syndrome in Vietnam. Emerg Infect Dis 25: 1029–1031.
-
7.
Yoo JR, Heo ST, Park D, Kim H, Fukuma A, Fukushi S, Shimojima M, Lee KH, 2016. Family cluster analysis of severe fever with thrombocytopenia syndrome virus infection in Korea. Am J Trop Med Hyg 95: 1351–1357.
-
8.
Wi YM, Woo HI, Park D, Lee KH, Kang CI, Chung DR, Peck KR, Song JH, 2016. Severe fever with thrombocytopenia syndrome in patients suspected of having scrub typhus. Emerg Infect Dis 22: 1992–1995.
-
9.
Yoo JR, Heo ST, Kang JH, Park D, Kim JS, Bae JH, Woo JJ, Kim S, Lee KH, 2018. Mixed infection with severe fever with thrombocytopenia syndrome virus and two genotypes of scrub typhus in a patient, South Korea, 2017. Am J Trop Med Hyg 99: 287–290.
-
10.
Zhang YZ et al. 2012. Hemorrhagic fever caused by a novel bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis 54: 527–533.
-
11.
Yun Y et al. 2015. Phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in South Korea and migratory bird routes between China, South Korea, and Japan. Am J Trop Med Hyg 93: 468–474.
-
12.
Lee YM, Kim DM, Lee SH, Jang MS, Neupane GP, 2011. Phylogenetic analysis of the 56 kDa protein genes of Orientia tsutsugamushi in southwest area of Korea. Am J Trop Med Hyg 84: 250–254.
-
13.
Kim G et al. 2017. Diversification of Orientia tsutsugamushi genotypes by intragenic recombination and their potential expansion in endemic areas. PLoS Negl Trop Dis 11: e0005408.
-
14.
Ha NY, Kim Y, Min CK, Kim HI, Yen NTH, Choi MS, Kang JS, Kim YS, Cho NH, 2017. Longevity of antibody and T-cell responses against outer membrane antigens of Orientia tsutsugamushi in scrub typhus patients. Emerg Microbes Infect 6: e116.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 49 | 49 | 13 |
| Full Text Views | 948 | 267 | 3 |
| PDF Downloads | 346 | 82 | 1 |