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Seroprevalence of Hepatitis A and Hepatitis E Viruses among Pregnant Women in Haiti

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  • 1 US Centers for Disease Control and Prevention, Atlanta, Georgia;
  • | 2 National Public Health Laboratory, Ministry of Public Health and Population, Port-au-Prince, Haiti;
  • | 3 Oak Ridge Institute for Science and Education, Centers for Disease Control and Prevention, Atlanta, Georgia;
  • | 4 Federal University of Mato Grosso do Sul, Campo Grande, Brazil
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Hepatitis E virus (HEV) infection is associated with a high fatality rate among pregnant women, and gestational complications have been reported among pregnant women infected with hepatitis A virus (HAV). The aim of this study was to determine the seroprevalence of HAV and HEV infections among pregnant women in Haiti. We stratified the population (n = 1,307) between West and non-West regions. Specimens were tested for total HAV antibody (anti-HAV), and IgM and IgG HEV antibody (anti-HEV). Overall, 96.8% pregnant women were positive for total anti-HAV, 10.3% for IgG anti-HEV, and 0.3% for IgM anti-HEV. The prevalence of IgG anti-HEV in the non-West region (12.3%) was significantly greater than that in the West region (5.3%) (P < 0.0001). Most pregnant women in Haiti had evidence of past exposure and immunity to HAV. The non-West region had a higher prevalence of HEV. Improvement in water and sanitation will help in the prevention and control of these infections in Haiti.

Author Notes

Address correspondence to Alexandra Tejada-Strop, US Centers for Disease Control and Prevention, MS-A33, 1600 Clifton Rd. NE, Atlanta, GA 30329. E-mail: wth9@cdc.gov

Authors’ addresses: Alexandra Tejada-Strop, Rania A. Tohme, Xin Ji, and Saleem Kamili, US Centers for Disease Control and Prevention, Atlanta, GA, E-mails: wth9@cdc.gov, ihb1@cdc.gov, jixinjl@gmail.com, and sek6@cdc.gov. Jocelyne Andre-Alboth and Jacques Boncy, National Public Health Laboratory, Ministry of Public Health and Population, Port-au-Prince, Haiti, E-mails: alboth28@yahoo.fr and jboncy2001@yahoo.fr. Lana Childs, Oak Ridge Institute for Science and Education, Centers for Disease Control and Prevention, Atlanta, GA and US Centers for Disease Control and Prevention, Atlanta, GA, E-mail: yqj9@cdc.gov. Vivianne de Oliveira Landgraf de Castro, Federal University of Mato Grosso do Sul, Campo Grande, Brazil, E-mail: vikalandgraf@hotmail.com.

Disclosure: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC.

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