Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Centers for Disease Control and Prevention (CDC), 2018. Parasites—Fascioliasis (Fasciola Infection): Biology. Available at: http://www.cdc.gov/parasites/fasciola/biology.html. Accessed December 7, 2018.
-
2.
Centers for Disease Control and Prevention (CDC), 2018. Parasites—Fascioliasis (Fasciola Infection): Epidemiology and Risk Factors. Available at: http://www.cdc.gov/parasites/fasciola/epi.html. Accessed December 7, 2018.
-
3.
Ashrafi K, Bargues MD, O’Neill S, Mas-Coma S, 2014. Fascioliasis: a worldwide parasitic disease of importance in travel medicine. Trav Med Infect Dis 12: 636–649.
-
4.
Mas-Coma S, 2005. Epidemiology of fascioliasis in human endemic areas. J Helminthol 79: 207–216.
-
5.
World Health Organization (WHO), 2006. Report of the WHO Informal Meeting on Use of Triclabendazole in Fascioliasis Control. Available at: http://www.who.int/neglected_diseases/preventive_chemotherapy/WHO_CDS_NTD_PCT_2007.1.pdf. Accessed December 7, 2018.
-
6.
Esteban JG, Flores A, Angles R, Strauss W, Aguirre C, Mas-Coma S, 1997. A population-based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano. Trop Med Int Health 2: 695–699.
-
7.
Mas-Coma S, Anglés R, Esteban JG, Bargues MD, Buchon P, Franken M, Strauss W, 1999. The northern Bolivian Altiplano: a region highly endemic for human fascioliasis. Trop Med Int Health 4: 454–467.
-
8.
1991. Available at: http://microbeonline.com/kato-katz-technique-principle-procedure-results. Accessed December 7, 2018.
-
9.
Mas-Coma S, Funatsu IR, Bargues MD, 2001. Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America. Parasitology 123 (Suppl): S115–S127.
-
10.
Venturina VM, Alejandro MA, Baltazar CP, Abes NS, Mingala CN, 2015. Evidence of Fasciola spp. resistance to albendazole, triclabendazole and bromofenofos in water buffaloes (Bubalus bubalis). Ann Parasitol 61: 283–289.
-
11.
Novobilský A, Amaya Solis N, Skarin M, Höglund J, 2016. Assessment of flukicide efficacy against Fasciola hepatica in sheep in Sweden in the absence of a standardised test. Int J Parasitol Drugs Drug Resist 6: 141–147.
-
12.
Dugernier T, Geubel A, Bigaignon G, Cesbron JY, Coche E, 1986. Human fascioliasis: cure by mebendazole? A case report. Gastroenterol Clin Biol 10: 513–516.
-
13.
Cabada MM, Lopez M, Arque E, Clinton White A, 2014. Prevalence of soil-transmitted helminths after mass albendazole administration in an indigenous community of the Manu jungle in Peru. Pathog Glob Health 108: 200–205.
-
14.
Lopez M, White AC, Cabada MM, 2012. Burden of Fasciola hepatica infection among children from Paucartambo in Cusco, Peru. Am J Trop Med Hyg 86: 481–485.
-
15.
Cabada MM, Goodrich MR, Graham B, Villanueva-Meyer PG, Lopez M, Arque E, White AC, 2014. Fascioliasis and eosinophilia in the highlands of Cuzco, Peru and their association with water and socioeconomic factors. Am J Trop Med Hyg 91: 989–993.
-
16.
Curtale F, Abd-el Wahab Hassanein Y, El Wakeel A, Barduagni P, Savioli L, 2003. The school health programme in Behera: an integrated helminth control programme at governorate level in Egypt. Acta Trop 86: 295–307.
-
17.
Curtale F, Hassanein YA, Savioli L, 2005. Control of human fascioliasis by selective chemotherapy: design, cost and effect of the first public health, school-based intervention implemented in endemic areas of the Nile Delta, Egypt. Trans R Soc Trop Med Hyg 99: 599–609.
-
18.
WHO, 2012. Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases. Available at: http://www.who.int/neglected_diseases/NTD_RoadMap_2012_Fullversion.pdf. Accessed December 7, 2018.
-
19.
Abudho BO, Ndombi EM, Guya B, Carter JM, Riner DK, Kittur N, Karanja DMS, Secor WE, Colley DG, 2018. Impact of four years of annual mass drug administration on prevalence and intensity of schistosomiasis among primary and high school children in western Kenya: a repeated cross-sectional study. Am J Trop Med Hyg 98: 1397–1402.
-
20.
Kittur N, Binder S, Campbell CH, King CH, Kinung’hi S, Olsen A, Magnussen P, Colley DG, 2017. Defining persistent hotspots: areas that fail to decrease meaningfully in prevalence after multiple years of mass drug administration with praziquantel for control of schistosomiasis. Am J Trop Med Hyg 97: 1810–1817.
-
21.
Rujeni N, Morona D, Ruberanziza E, Mazigo HD, 2017. Schistosomiasis and soil-transmitted helminthiasis in Rwanda: an update on their epidemiology and control. Infect Dis Poverty 6: 8.
-
22.
Ross AG et al. 2015. Can mass drug administration lead to the sustainable control of schistosomiasis? J Infect Dis 211: 283–289.
-
23.
Inobaya MT et al. 2018. Mass drug administration and the sustainable control of schistosomiasis: an evaluation of treatment compliance in the rural Philippines. Parasit Vectors 11: 441.
-
24.
Lelo AE et al. 2014. No apparent reduction in schistosome burden or genetic diversity following four years of school-based mass drug administration in Mwea, central Kenya, a heavy transmission area. PLoS Negl Trop Dis 8: e3221.
-
25.
Tchuem Tchuenté LA, Rollinson D, Stothard JR, Molyneux D, 2017. Moving from control to elimination of schistosomiasis in sub-Saharan Africa: time to change and adapt strategies. Infect Dis Poverty 6: 42.
-
26.
Villegas F et al. 2012. Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano. PLoS Negl Trop Dis 6: e1720.
-
27.
Maco V, Marcos L, Delgado J, Herrera J, Nestares J, Terashima A, Samalvides F, Gotuzzo E, 2015. Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children. Rev Soc Bras Med Trop 48: 445–453.
-
28.
Kelley JM, Elliott TP, Beddoe T, Anderson G, Skuce P, Spithill TW, 2016. Current threat of triclabendazole resistance in Fasciola hepatica. Trends Parasitol 32: 458–469.
-
29.
Cabada MM, Lopez M, Cruz M, Delgado JR, Hill V, White AC, 2016. Treatment failure after multiple courses of triclabendazole among patients with fascioliasis in Cusco, Peru: a case series. PLoS Negl Trop Dis 10: e0004361.
-
30.
Webb CM, Cabada MM, 2018. Recent developments in the epidemiology, diagnosis, and treatment of Fasciola infection. Curr Opin Infect Dis 31: 409–414.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 41 | 41 | 14 |
| Full Text Views | 741 | 122 | 0 |
| PDF Downloads | 186 | 32 | 0 |
Mass Drug Administration of Triclabendazole for Fasciola Hepatica in Bolivia
Sergio Mollinedo
Sergio Mollinedo
Instituto de Salud y Medio Ambiente (ISMA), La Paz, Bolivia;
Search for other papers by Sergio Mollinedo in
Current site
Google Scholar
PubMed
Search for other papers by Sergio Mollinedo in
Current site
Google Scholar
PubMed
Patricia Gutierrez
Patricia Gutierrez
FUNDERMA (Fundación Nacional de Dermatología), Santa Cruz, Bolivia;
Search for other papers by Patricia Gutierrez in
Current site
Google Scholar
PubMed
Search for other papers by Patricia Gutierrez in
Current site
Google Scholar
PubMed
Rosa Azurduy
Rosa Azurduy
Servicio Departamental de Salud (SEDES), La Paz, Bolivia;
Search for other papers by Rosa Azurduy in
Current site
Google Scholar
PubMed
Search for other papers by Rosa Azurduy in
Current site
Google Scholar
PubMed
Freddy Valle
Freddy Valle
Servicio Departamental de Salud (SEDES), La Paz, Bolivia;
Search for other papers by Freddy Valle in
Current site
Google Scholar
PubMed
Search for other papers by Freddy Valle in
Current site
Google Scholar
PubMed
Alejandra Salas
Alejandra Salas
Servicio Departamental de Salud (SEDES), La Paz, Bolivia;
Search for other papers by Alejandra Salas in
Current site
Google Scholar
PubMed
Search for other papers by Alejandra Salas in
Current site
Google Scholar
PubMed
Zoraida Mollinedo
Zoraida Mollinedo
Universidad Amazónica de Pando, Pando, Bolivia;
Search for other papers by Zoraida Mollinedo in
Current site
Google Scholar
PubMed
Search for other papers by Zoraida Mollinedo in
Current site
Google Scholar
PubMed
Paula Soto
Paula Soto
FUNDERMA (Fundación Nacional de Dermatología), Santa Cruz, Bolivia;
Search for other papers by Paula Soto in
Current site
Google Scholar
PubMed
Search for other papers by Paula Soto in
Current site
Google Scholar
PubMed
Cleye F. Villarroel
Cleye F. Villarroel
Instituto de Salud y Medio Ambiente (ISMA), La Paz, Bolivia;
Search for other papers by Cleye F. Villarroel in
Current site
Google Scholar
PubMed
Search for other papers by Cleye F. Villarroel in
Current site
Google Scholar
PubMed
Janet Ransom
Janet Ransom
Fast-Track Drugs and Biologics, North Potomac, Maryland;
Search for other papers by Janet Ransom in
Current site
Google Scholar
PubMed
Search for other papers by Janet Ransom in
Current site
Google Scholar
PubMed
Robb Lawrence
Robb Lawrence
Chesapeake Therapeutics, Owings Mills, Maryland;
Search for other papers by Robb Lawrence in
Current site
Google Scholar
PubMed
Search for other papers by Robb Lawrence in
Current site
Google Scholar
PubMed
Jonathan Berman
Jonathan Berman
AB Foundation, North Bethesda, Maryland
Search for other papers by Jonathan Berman in
Current site
Google Scholar
PubMed
Search for other papers by Jonathan Berman in
Current site
Google Scholar
PubMed
Jaime Soto
Jaime Soto
FUNDERMA (Fundación Nacional de Dermatología), Santa Cruz, Bolivia;
Search for other papers by Jaime Soto in
Current site
Google Scholar
PubMed
Search for other papers by Jaime Soto in
Current site
Google Scholar
PubMed
Human infection with Fasciola hepatica leads to obstruction of the common bile duct by adult worms and disease characterized by biliary colic, epigastric pain, and nausea. Recommended treatment is a single dose of triclabendazole (TCBZ) (10 mg/kg). Because in the 1990s the Bolivian Altiplano bordering Lake Titicaca was thought to have the highest prevalence of human fascioliasis worldwide, the Bolivian Ministry of Health instituted TCBZ mass drug administration (MDA). From 2008 to 2016 (excepting 2015), one dose of 250 mg was administered, usually in September/October, to each resident of highly endemic regions willing to participate. This is apparently the first reported use of MDA for Fasciola. The proportion of persons in key regions receiving TCBZ MDA was 87% in 2016. In 2017, we resurveyed key regions, and found that the MDA program had been dramatically successful. Whereas Fasciola prevalence was reported as 26.9% in Huacullani/Tiahuanaco and 12.6% in Batallas in 1999, there was 0.7% prevalence in Huacullani/Tiahuanaco and 1% in Batallas in 2017. However, lessons from schistosomiasis control efforts suggest that for sustained control of Fasciola infection, Fasciola MDA needs to be maintained and coupled with measures to control infection in the intermediary snail and in the animal hosts of F. hepatica.
Author Notes
Disclosure: J. B. is an officer of the AB Foundation.
Financial support: Funded by a grant to J. S. from the AB Foundation.
Authors’ addresses: Sergio Mollinedo and Cleye F. Villarroel, Instituto de Salud y Medio Ambiente (ISMA), La Paz, Bolivia, E-mails: jsergiomollinedo@gmail.com and labomollinedo@msn.com. Patricia Gutierrez, Jaime Soto, and Paula Soto, FUNDERMA (Fundación Nacional de Dermatología), Santa Cruz, Bolivia, E-mails: pgutierrezduenas@gmail.com, dra.paula.dermalaser@gmail.com, and jaime.soto@infoleis.com. Rosa Azurduy, Freddy Valle, and Alejandra Salas, Servicio Departamental de Salud (SEDES), La Paz, Bolivia, E-mails: rosazurduy@hotmail.com, freddyvallelpz@gmail.com, and asalcla@yahoo.es. Zoraida Mollinedo, Universidad Amazónica de Pando, Pando, Bolivia, E-mail: zoridex@gmail.com. Janet Ransom, Fast-Track Drugs and Biologics, North Potomac, MD, E-mail: jransom@fasttrackresearch.com. Robb Lawrence, Chesapeake Therapeutics, Reistertown, MD, E-mail: rlawrence@chesapeaketherapeutics.com. Jonathan Berman, AB Foundation, North Bethesda, MD, E-mail: jbe9320457@aol.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Centers for Disease Control and Prevention (CDC), 2018. Parasites—Fascioliasis (Fasciola Infection): Biology. Available at: http://www.cdc.gov/parasites/fasciola/biology.html. Accessed December 7, 2018.
-
2.
Centers for Disease Control and Prevention (CDC), 2018. Parasites—Fascioliasis (Fasciola Infection): Epidemiology and Risk Factors. Available at: http://www.cdc.gov/parasites/fasciola/epi.html. Accessed December 7, 2018.
-
3.
Ashrafi K, Bargues MD, O’Neill S, Mas-Coma S, 2014. Fascioliasis: a worldwide parasitic disease of importance in travel medicine. Trav Med Infect Dis 12: 636–649.
-
4.
Mas-Coma S, 2005. Epidemiology of fascioliasis in human endemic areas. J Helminthol 79: 207–216.
-
5.
World Health Organization (WHO), 2006. Report of the WHO Informal Meeting on Use of Triclabendazole in Fascioliasis Control. Available at: http://www.who.int/neglected_diseases/preventive_chemotherapy/WHO_CDS_NTD_PCT_2007.1.pdf. Accessed December 7, 2018.
-
6.
Esteban JG, Flores A, Angles R, Strauss W, Aguirre C, Mas-Coma S, 1997. A population-based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano. Trop Med Int Health 2: 695–699.
-
7.
Mas-Coma S, Anglés R, Esteban JG, Bargues MD, Buchon P, Franken M, Strauss W, 1999. The northern Bolivian Altiplano: a region highly endemic for human fascioliasis. Trop Med Int Health 4: 454–467.
-
8.
1991. Available at: http://microbeonline.com/kato-katz-technique-principle-procedure-results. Accessed December 7, 2018.
-
9.
Mas-Coma S, Funatsu IR, Bargues MD, 2001. Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America. Parasitology 123 (Suppl): S115–S127.
-
10.
Venturina VM, Alejandro MA, Baltazar CP, Abes NS, Mingala CN, 2015. Evidence of Fasciola spp. resistance to albendazole, triclabendazole and bromofenofos in water buffaloes (Bubalus bubalis). Ann Parasitol 61: 283–289.
-
11.
Novobilský A, Amaya Solis N, Skarin M, Höglund J, 2016. Assessment of flukicide efficacy against Fasciola hepatica in sheep in Sweden in the absence of a standardised test. Int J Parasitol Drugs Drug Resist 6: 141–147.
-
12.
Dugernier T, Geubel A, Bigaignon G, Cesbron JY, Coche E, 1986. Human fascioliasis: cure by mebendazole? A case report. Gastroenterol Clin Biol 10: 513–516.
-
13.
Cabada MM, Lopez M, Arque E, Clinton White A, 2014. Prevalence of soil-transmitted helminths after mass albendazole administration in an indigenous community of the Manu jungle in Peru. Pathog Glob Health 108: 200–205.
-
14.
Lopez M, White AC, Cabada MM, 2012. Burden of Fasciola hepatica infection among children from Paucartambo in Cusco, Peru. Am J Trop Med Hyg 86: 481–485.
-
15.
Cabada MM, Goodrich MR, Graham B, Villanueva-Meyer PG, Lopez M, Arque E, White AC, 2014. Fascioliasis and eosinophilia in the highlands of Cuzco, Peru and their association with water and socioeconomic factors. Am J Trop Med Hyg 91: 989–993.
-
16.
Curtale F, Abd-el Wahab Hassanein Y, El Wakeel A, Barduagni P, Savioli L, 2003. The school health programme in Behera: an integrated helminth control programme at governorate level in Egypt. Acta Trop 86: 295–307.
-
17.
Curtale F, Hassanein YA, Savioli L, 2005. Control of human fascioliasis by selective chemotherapy: design, cost and effect of the first public health, school-based intervention implemented in endemic areas of the Nile Delta, Egypt. Trans R Soc Trop Med Hyg 99: 599–609.
-
18.
WHO, 2012. Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases. Available at: http://www.who.int/neglected_diseases/NTD_RoadMap_2012_Fullversion.pdf. Accessed December 7, 2018.
-
19.
Abudho BO, Ndombi EM, Guya B, Carter JM, Riner DK, Kittur N, Karanja DMS, Secor WE, Colley DG, 2018. Impact of four years of annual mass drug administration on prevalence and intensity of schistosomiasis among primary and high school children in western Kenya: a repeated cross-sectional study. Am J Trop Med Hyg 98: 1397–1402.
-
20.
Kittur N, Binder S, Campbell CH, King CH, Kinung’hi S, Olsen A, Magnussen P, Colley DG, 2017. Defining persistent hotspots: areas that fail to decrease meaningfully in prevalence after multiple years of mass drug administration with praziquantel for control of schistosomiasis. Am J Trop Med Hyg 97: 1810–1817.
-
21.
Rujeni N, Morona D, Ruberanziza E, Mazigo HD, 2017. Schistosomiasis and soil-transmitted helminthiasis in Rwanda: an update on their epidemiology and control. Infect Dis Poverty 6: 8.
-
22.
Ross AG et al. 2015. Can mass drug administration lead to the sustainable control of schistosomiasis? J Infect Dis 211: 283–289.
-
23.
Inobaya MT et al. 2018. Mass drug administration and the sustainable control of schistosomiasis: an evaluation of treatment compliance in the rural Philippines. Parasit Vectors 11: 441.
-
24.
Lelo AE et al. 2014. No apparent reduction in schistosome burden or genetic diversity following four years of school-based mass drug administration in Mwea, central Kenya, a heavy transmission area. PLoS Negl Trop Dis 8: e3221.
-
25.
Tchuem Tchuenté LA, Rollinson D, Stothard JR, Molyneux D, 2017. Moving from control to elimination of schistosomiasis in sub-Saharan Africa: time to change and adapt strategies. Infect Dis Poverty 6: 42.
-
26.
Villegas F et al. 2012. Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano. PLoS Negl Trop Dis 6: e1720.
-
27.
Maco V, Marcos L, Delgado J, Herrera J, Nestares J, Terashima A, Samalvides F, Gotuzzo E, 2015. Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children. Rev Soc Bras Med Trop 48: 445–453.
-
28.
Kelley JM, Elliott TP, Beddoe T, Anderson G, Skuce P, Spithill TW, 2016. Current threat of triclabendazole resistance in Fasciola hepatica. Trends Parasitol 32: 458–469.
-
29.
Cabada MM, Lopez M, Cruz M, Delgado JR, Hill V, White AC, 2016. Treatment failure after multiple courses of triclabendazole among patients with fascioliasis in Cusco, Peru: a case series. PLoS Negl Trop Dis 10: e0004361.
-
30.
Webb CM, Cabada MM, 2018. Recent developments in the epidemiology, diagnosis, and treatment of Fasciola infection. Curr Opin Infect Dis 31: 409–414.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 41 | 41 | 14 |
| Full Text Views | 741 | 122 | 0 |
| PDF Downloads | 186 | 32 | 0 |