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Brown RL, Clarke TB, 2016. The regulation of host defences to infection by the microbiota. Immunology 150: 1–6.
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Blanton LV et al. 2016. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science 351: 7.
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3.
Davis CD, 2016. The gut microbiome and its role in obesity. Nutr Today 51: 167–174.
-
4.
Honda K, Littman DR, 2012. The microbiome in infectious disease and inflammation. Annu Rev Immunol 30: 759–795.
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5.
Partida-Rodríguez O, Serrano-Vázquez A, Nieves-Ramírez ME, Moran P, Rojas L, Portillo T, González E, Hernández E, Finlay BB, Ximenez C, 2017. Human intestinal microbiota: interaction between parasites and the host immune response. Arch Med Res 48: 690–700.
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6.
Brosschot TP, Reynolds LA, 2018. The impact of a helminth-modified microbiome on host immunity. Mucosal Immunol 11: 1039–1046.
-
7.
Jenkins TP, Rathnayaka Y, Perera PK, Peachey LE, Nolan MJ, Krause L, Rajakaruna RS, Cantacessi C, 2017. Infections by human gastrointestinal helminths are associated with changes in faecal microbiota diversity and composition. PLoS One 12: e0184719.
-
8.
Kay GL, Millard A, Sergeant MJ, Midzi N, Gwisai R, Mduluza T, Ivens A, Nausch N, Mutapi F, Pallen M, 2015. Differences in the faecal microbiome in Schistosoma haematobium infected children vs. uninfected children. PLos Negl Trop Dis 9: e0003861.
-
9.
Lee SC et al. 2014. Helminth colonization is associated with increased diversity of the gut microbiota PLoS Negl Trop Dis 8: e2880.
-
10.
Rosa BA et al. 2018. Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia. Microbiome 6: 33.
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11.
Maizels RM, McSorley HJ, 2016. Regulation of the host immune system by helminth parasites. J Allergy Clin Immunol 138: 666–675.
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12.
Yilmaz B et al. 2014. Gut microbiota elicits a protective immune response against malaria transmission. Cell 159: 1277–1289.
-
13.
Villarino NF, LeCleir GR, Denny JE, Dearth SP, Harding CL, Sloan SS, Gribble JL, Campagna SR, Wilhelm SW, Schmidt NW, 2016. Composition of the gut microbiota modulates the severity of malaria. Proc Natl Acad Sci USA 113: 2235–2240.
-
14.
Yooseph S et al. 2015. Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection. BMC Genomics 16: 15.
-
15.
Salam N, Azam S, 2017. Prevalence and distribution of soil-transmitted helminth infections in India. BMC Public Healt 17: 201.
-
16.
Anvikar AR, Shah N, Dhariwal AC, Sonal GS, Pradhan MM, Ghosh SK, Valecha N, 2016. Epidemiology of Plasmodium vivax malaria in India. Am J Trop Med Hyg 95: 108–120.
-
17.
Edgar RC, 2013. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat Methods 10: 996.
-
18.
Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C, 2011. Metagenomic biomarker discovery and explanation. Genome Biol 12: R60.
-
19.
Ghosh TS, Sen Gupta S, Bhattacharya T, Yadav D, Barik A, Chowdhury A, Das B, Mande SS, Nair GB, 2014. Gut microbiomes of Indian children of varying nutritional status. PLoS One 9: e95547.
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20.
De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P, 2010. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 107: 14691.
-
21.
Banks SC, Cary GJ, Smith AL, Davies ID, Driscoll DA, Gill AM, Lindenmayer DB, Peakall R, 2013. How does ecological disturbance influence genetic diversity? Trends Ecol Evol 28: 670–679.
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Interactions between Parasitic Infections and the Human Gut Microbiome in Odisha, India
Tiffany Huwe
Tiffany Huwe
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana;
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Birendra Kumar Prusty
Birendra Kumar Prusty
District Diagnostic Laboratory, Malkangiri, India;
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Aisurya Ray
Aisurya Ray
Institute of Life Sciences, Bhubaneswar, India
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Shaun Lee
Shaun Lee
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana;
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Balachandran Ravindran
Balachandran Ravindran
Institute of Life Sciences, Bhubaneswar, India
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Edwin Michael
Edwin Michael
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana;
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Soil-transmitted helminth (STH) infections and malaria are parasitic diseases with enormous global health burdens. Research has demonstrated a relationship between each of these parasites and the gut microbiome, suggesting that the gut microbiota may be implicated in governing host susceptibility to diverse pathogens, and perhaps even coinfection by different pathogens, through similar microbiome-influenced pathways. Here, we have derived a first microbiome community profile associated with STH infections in Odisha, India, and tested the hypothesis that the gut microbiome can modulate host susceptibility to multiple parasite infections through the same pathways. This study revealed several bacterial taxa negatively associated with specific STH infections, including Lactobacillus and Lachnospiracaea. Our results also suggest that relative abundance of Lactobacillus is driven by the STH infection status more so than by the Plasmodium infection status. This study contributes to efforts to understand the effects of the microbiome on host susceptibility to parasitic infections in endemic communities.
Author Notes
Authors’ addresses: Tiffany Huwe, Shaun Lee, and Edwin Michael, University of Notre Dame, Notre Dame, IN, E-mails: thuwe@nd.edu, shaun.w.lee.310@nd.edu, and emichael@nd.edu. Birendra Kumar Prusty, District Diagnostic Laboratory, Malkangiri, India, E-mail: drbirendraprusty@gmail.com. Aisurya Ray, Institute of Life Sciences, Bhubaneswar, India, E-mail: ray.aisurya123@gmail.com. Balachandran Ravindran, Institute of Life Sciences, Bhubaneswar, India, E-mail: ravindran8@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Brown RL, Clarke TB, 2016. The regulation of host defences to infection by the microbiota. Immunology 150: 1–6.
-
2.
Blanton LV et al. 2016. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science 351: 7.
-
3.
Davis CD, 2016. The gut microbiome and its role in obesity. Nutr Today 51: 167–174.
-
4.
Honda K, Littman DR, 2012. The microbiome in infectious disease and inflammation. Annu Rev Immunol 30: 759–795.
-
5.
Partida-Rodríguez O, Serrano-Vázquez A, Nieves-Ramírez ME, Moran P, Rojas L, Portillo T, González E, Hernández E, Finlay BB, Ximenez C, 2017. Human intestinal microbiota: interaction between parasites and the host immune response. Arch Med Res 48: 690–700.
-
6.
Brosschot TP, Reynolds LA, 2018. The impact of a helminth-modified microbiome on host immunity. Mucosal Immunol 11: 1039–1046.
-
7.
Jenkins TP, Rathnayaka Y, Perera PK, Peachey LE, Nolan MJ, Krause L, Rajakaruna RS, Cantacessi C, 2017. Infections by human gastrointestinal helminths are associated with changes in faecal microbiota diversity and composition. PLoS One 12: e0184719.
-
8.
Kay GL, Millard A, Sergeant MJ, Midzi N, Gwisai R, Mduluza T, Ivens A, Nausch N, Mutapi F, Pallen M, 2015. Differences in the faecal microbiome in Schistosoma haematobium infected children vs. uninfected children. PLos Negl Trop Dis 9: e0003861.
-
9.
Lee SC et al. 2014. Helminth colonization is associated with increased diversity of the gut microbiota PLoS Negl Trop Dis 8: e2880.
-
10.
Rosa BA et al. 2018. Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia. Microbiome 6: 33.
-
11.
Maizels RM, McSorley HJ, 2016. Regulation of the host immune system by helminth parasites. J Allergy Clin Immunol 138: 666–675.
-
12.
Yilmaz B et al. 2014. Gut microbiota elicits a protective immune response against malaria transmission. Cell 159: 1277–1289.
-
13.
Villarino NF, LeCleir GR, Denny JE, Dearth SP, Harding CL, Sloan SS, Gribble JL, Campagna SR, Wilhelm SW, Schmidt NW, 2016. Composition of the gut microbiota modulates the severity of malaria. Proc Natl Acad Sci USA 113: 2235–2240.
-
14.
Yooseph S et al. 2015. Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection. BMC Genomics 16: 15.
-
15.
Salam N, Azam S, 2017. Prevalence and distribution of soil-transmitted helminth infections in India. BMC Public Healt 17: 201.
-
16.
Anvikar AR, Shah N, Dhariwal AC, Sonal GS, Pradhan MM, Ghosh SK, Valecha N, 2016. Epidemiology of Plasmodium vivax malaria in India. Am J Trop Med Hyg 95: 108–120.
-
17.
Edgar RC, 2013. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat Methods 10: 996.
-
18.
Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C, 2011. Metagenomic biomarker discovery and explanation. Genome Biol 12: R60.
-
19.
Ghosh TS, Sen Gupta S, Bhattacharya T, Yadav D, Barik A, Chowdhury A, Das B, Mande SS, Nair GB, 2014. Gut microbiomes of Indian children of varying nutritional status. PLoS One 9: e95547.
-
20.
De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P, 2010. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 107: 14691.
-
21.
Banks SC, Cary GJ, Smith AL, Davies ID, Driscoll DA, Gill AM, Lindenmayer DB, Peakall R, 2013. How does ecological disturbance influence genetic diversity? Trends Ecol Evol 28: 670–679.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 106 | 106 | 31 |
| Full Text Views | 735 | 159 | 0 |
| PDF Downloads | 454 | 79 | 0 |