Significance of Autophagy in Dengue Virus Infection: A Brief Review

Bishwanath Acharya Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand;

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Sonam Gyeltshen Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand;

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Wanna Chaijaroenkul Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand;

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Kesara Na-Bangchang Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand;
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand

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Dengue virus (DENV) causes asymptomatic to severe life-threatening infections and affects millions of people worldwide. Autophagy, a cellular degradative pathway, has both proviral and antiviral functions. Dengue virus triggers the autophagy pathway for the successful replication of its genome. However, the exact mechanism and the viral factors involved in activating this pathway remain unclear. This review summarizes the existing knowledge on the mechanism of autophagy induction and its significance during DENV infection.

Author Notes

Address correspondence to Kesara Na-Bangchang, Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, 99 Moo 18 Paholyothin Rd., Pathum Thani 12120, Thailand. E-mail: kesaratmu@yahoo.com

Authors’ addresses: Bishwanath Acharya, Sonam Gyeltshen, and Wanna Chaijaroenkul, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand, E-mails: bacharya777@gmail.com, sonamdruk2017@gmail.com, and wn_ap39@yahoo.com. Kesara Na-Bangchang, Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand, E-mail: kesaratmu@yahoo.com.

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