Case Report: Two Cases of Cholangiocarcinoma in Patients with Opisthorchis felineus Infection in Western Siberia, Russian Federation

Yulia V. Kovshirina Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;

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Olga S. Fedorova Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;

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Sergey V. Vtorushin Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;

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Anna E. Kovshirina Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;

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Stanislav D. Ivanov Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;

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Andrey V. Chizhikov Budget Institution of Higher Education of Khanty-Mansiysk Autonomous Okrug, Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russian Federation;

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Sergey V. Onishchenko Budget Institution of Higher Education of Khanty-Mansiysk Autonomous Okrug, Surgut State University, Surgut, Russian Federation;

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Ludmila M. Ogorodova Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;

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Peter Odermatt Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland;
University of Basel, Basel, Switzerland

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Cholangiocarcinoma (CCA) is a cancer with high mortality owing to its aggressiveness and resistance to therapy. The liver flukes of the Opisthorchiidae family have been recognized as risk factors of CCA. Opisthorchis felineus infection occurs in Western Siberia, the biggest endemic area in the Russian Federation, and is associated with chronic inflammation of the bile ducts, which may be linked to severe hepatobiliary morbidity. We report two cases of confirmed CCA who had a chronic O. felineus infection. Both cases presented unspecific symptoms at the onset of the disease, a stage when severe pathological changes already had occurred. Both patients were living in endemic areas but did not receive any antihelminthic treatment. This report underlines the need for assessment of O. felineus infection as a causative factor of CCA. The results will provide further arguments for control of O. felineus in the Russian Federation.

Author Notes

Address correspondence to Olga S. Fedorova, Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Moscowsky Tract, 2, Tomsk 634050, Russian Federation. E-mail: olga.sergeevna.fedorova@gmail.com

Financial support: This work was supported by the Russian Science Foundation (“Metabolic changes in the parasite-host interaction at the organ and organism level,” N14-15-00247, to O. S. F., L. M. O.) and grant of Tomsk State University (“Relationship between opisthorchiasis and cholangiocarcinoma in Western Siberia: case-control study,” N7407, to Yu. V. K., A. E. K., A. V. C., S. V. O.).

Ethical approval: Study procedures followed the ethical standards of the Helsinki Declaration of the World Medical Association. Ethical Approval was obtained from the Ethical Committee of Siberian State Medical University (N4384, November 30, 2015). Patient’s written informed consent was obtained. All information was anonymized.

Authors’ addresses: Yulia V. Kovshirina, Department of Infectious Diseases and Epidemiology, Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation, E-mail: yulia.v.kovshirina@gmail.com. Olga S. Fedorova, Anna E. Kovshirina, and Ludmila M. Ogorodova, Department of Faculty Pediatrics, Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation, E-mails: olga.sergeevna.fedorova@gmail.com, annutakovshirina@gmail.com, and osf77@list.ru. Sergey V. Vtorushin, Department of Pathology, Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation, E-mail: wtorushin@rambler.ru. Stanislav D. Ivanov, Department of Faculty Pediatric, Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation, E-mail: ivanov_st@mail.ru. Andrey V. Chizhikov, Department of Oncology, Radiology, and Radiotheraphy, Budget Institution of Higher Education of Khanty-Mansiysk Autonomous Okrug, Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russian Federation, E-mail: tchandrey@mail.ru. Sergey V. Onishchenko, Department of Hospital Surgery, Budget Institution of Higher Education of Khanty-Mansiysk Autonomous Okrug, Surgut State University, Surgut, Russian Federation, E-mail: sergej-on@mail.ru. Peter Odermatt, Department Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland, and Department Public Health and Epidemiology, University of Basel, Basel, Switzerland, E-mail: peter.odermatt@unibas.ch.

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