Mas-Coma S, Bargues MD, Valero MA, 2018. Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures. Parasitology 145: 1665–1699.
Ashrafi K, Bargues MD, O’Neill S, Mas-Coma S, 2014. Fascioliasis: a worldwide parasitic disease of importance in travel medicine. Travel Med Infect Dis 12: 636–649.
Webb CM, Cabada MM, 2018. Recent developments in the epidemiology, diagnosis, and treatment of Fasciola infection. Curr Opin Infect Dis 31: 409–414.
Qureshi AW, Tanveer A, Mas-Coma S, 2016. Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan. Acta Trop 156: 157–164.
Furst T, Duthaler U, Sripa B, Utzinger J, Keiser J, 2012. Trematode infections: liver and lung flukes. Infect Dis Clin North Am 26: 399–419.
Mas-Coma S, 2005. Epidemiology of fascioliasis in human endemic areas. J Helminthol 79: 207–216.
Shin SH, Hsu A, Chastain HM, Cruz LA, Elder ES, Sapp SG, McAuliffe I, Espino AM, Handali S, 2016. Development of two FhSAP2 recombinant-based assays for immunodiagnosis of human chronic fascioliasis. Am J Trop Med Hyg 95: 852–855.
Maco V, Marcos L, Delgado J, Herrera J, Nestares J, Terashima A, Samalvides F, Gotuzzo E, 2015. Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children. Rev Soc Bras Med Trop 48: 445–453.
Kaya M, Bestas R, Cetin S, 2011. Clinical presentation and management of Fasciola hepatica infection: single-center experience. World J Gastroenterol 17: 4899–4904.
Marcos LA et al. 2008. Natural history, clinicoradiologic correlates, and response to triclabendazole in acute massive fascioliasis. Am J Trop Med Hyg 78: 222–227.
Bayhan GI, Batur A, Taylan-Ozkan A, Demiroren K, Beyhan YE, 2016. A pediatric case of fascioliasis with eosinophilic pneumonia. Turk J Pediatr 58: 109–112.
Aliaga L, Diaz M, Quiroga J, Arejola JM, Prieto J, 1984. Eosinophilic pulmonary disease caused by Fasciola hepatica. Description of a case and review of the literature. Med Clin (Barc) 82: 764–767.
Musa D, Godbole G, Chiodini PL, Phillips R, 2013. Unusual case of a lung abscess. BMJ Case Rep. doi: 10.1136/bcr-2012-008306.
Patel NU, Bang TJ, Dodd GD 3rd, 2016. CT findings of human Fasciola hepatica infection: case reports and review of the literature. Clin Imaging 40: 251–255.
Rodriguez Carnero P, Hernandez Mateo P, Martin-Garre S, Garcia Perez A, Del Campo L, 2017. Unexpected hosts: imaging parasitic diseases. Insights Imaging 8: 101–125.
Kelley JM, Elliott TP, Beddoe T, Anderson G, Skuce P, Spithill TW, 2016. Current threat of triclabendazole resistance in Fasciola hepatica. Trends Parasitol 32: 458–469.
Mas-Coma S, Angles R, Esteban JG, Bargues MD, Buchon P, Franken M, Strauss W, 1999. The northern Bolivian Altiplano: a region highly endemic for human fascioliasis. Trop Med Int Health 4: 454–467.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 1969 | 1373 | 408 |
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A 23-year-old recent emigrant from Afghanistan presented in August 2017 with severe wheezing and dyspnea that required hospital admission. Her illness was associated with marked peripheral blood eosinophilia (9,900–15,600/µL; 45.2–68%), as well as mild nausea, epigastric pain, and decreased appetite. She had lived until 3 months earlier in close proximity to cattle in her home in Kabul and did not recall eating watercress or other leafy plants associated with Fasciola hepatica transmission. Computerized tomography scanning showed bilateral ground-glass lung consolidations and multiple distinctive hypo-attenuating linear, tubuliform, and nodular liver lesions, including a large subcapsular hematoma. Numerous tests for rheumatological and malignant disorders were negative. Fasciola hepatica infestation was suspected on epidemiological, clinical, and radiographic grounds, and was confirmed by immunoblotting at the Centers for Disease Control (CDC). Multiple stool ova and parasite examinations were negative and endoscopic retrograde cholangiopancreatography did not identify trematodes. Her acute respiratory illness resolved with asthma-targeted therapies and her eosinophilia resolved with triclabendazole, which was obtained from CDC via an FDA Investigational New Drug application. Fascioliasis is uncommon in the United States, but the prolonged warfare and civil strife in Afghanistan and adjacent areas may lead to increased incidence outside the endemic region. Her case also demonstrates how hepatic imaging features of fascioliasis can be pathognomonic in clinical scenarios with eosinophilia and appropriate epidemiology and clinical features. We also highlight her relatively unusual presentation with symptoms of Loeffler-like syndrome alone.
Authors’ addresses: Martin Krsak and Eric M. Poeschla, Medicine (Infectious Diseases), University of Colorado at Denver–Anschutz Medical Campus, Aurora, CO, E-mails: martin.krsak@ucdenver.edu and eric.poeschla@ucdenver.edu. Nayana U. Patel, Department of Radiology, University of Colorado at Denver––Anschutz Medical Campus, Aurora, CO, E-mail: nayana.patel@ucdenver.edu.
Mas-Coma S, Bargues MD, Valero MA, 2018. Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures. Parasitology 145: 1665–1699.
Ashrafi K, Bargues MD, O’Neill S, Mas-Coma S, 2014. Fascioliasis: a worldwide parasitic disease of importance in travel medicine. Travel Med Infect Dis 12: 636–649.
Webb CM, Cabada MM, 2018. Recent developments in the epidemiology, diagnosis, and treatment of Fasciola infection. Curr Opin Infect Dis 31: 409–414.
Qureshi AW, Tanveer A, Mas-Coma S, 2016. Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan. Acta Trop 156: 157–164.
Furst T, Duthaler U, Sripa B, Utzinger J, Keiser J, 2012. Trematode infections: liver and lung flukes. Infect Dis Clin North Am 26: 399–419.
Mas-Coma S, 2005. Epidemiology of fascioliasis in human endemic areas. J Helminthol 79: 207–216.
Shin SH, Hsu A, Chastain HM, Cruz LA, Elder ES, Sapp SG, McAuliffe I, Espino AM, Handali S, 2016. Development of two FhSAP2 recombinant-based assays for immunodiagnosis of human chronic fascioliasis. Am J Trop Med Hyg 95: 852–855.
Maco V, Marcos L, Delgado J, Herrera J, Nestares J, Terashima A, Samalvides F, Gotuzzo E, 2015. Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children. Rev Soc Bras Med Trop 48: 445–453.
Kaya M, Bestas R, Cetin S, 2011. Clinical presentation and management of Fasciola hepatica infection: single-center experience. World J Gastroenterol 17: 4899–4904.
Marcos LA et al. 2008. Natural history, clinicoradiologic correlates, and response to triclabendazole in acute massive fascioliasis. Am J Trop Med Hyg 78: 222–227.
Bayhan GI, Batur A, Taylan-Ozkan A, Demiroren K, Beyhan YE, 2016. A pediatric case of fascioliasis with eosinophilic pneumonia. Turk J Pediatr 58: 109–112.
Aliaga L, Diaz M, Quiroga J, Arejola JM, Prieto J, 1984. Eosinophilic pulmonary disease caused by Fasciola hepatica. Description of a case and review of the literature. Med Clin (Barc) 82: 764–767.
Musa D, Godbole G, Chiodini PL, Phillips R, 2013. Unusual case of a lung abscess. BMJ Case Rep. doi: 10.1136/bcr-2012-008306.
Patel NU, Bang TJ, Dodd GD 3rd, 2016. CT findings of human Fasciola hepatica infection: case reports and review of the literature. Clin Imaging 40: 251–255.
Rodriguez Carnero P, Hernandez Mateo P, Martin-Garre S, Garcia Perez A, Del Campo L, 2017. Unexpected hosts: imaging parasitic diseases. Insights Imaging 8: 101–125.
Kelley JM, Elliott TP, Beddoe T, Anderson G, Skuce P, Spithill TW, 2016. Current threat of triclabendazole resistance in Fasciola hepatica. Trends Parasitol 32: 458–469.
Mas-Coma S, Angles R, Esteban JG, Bargues MD, Buchon P, Franken M, Strauss W, 1999. The northern Bolivian Altiplano: a region highly endemic for human fascioliasis. Trop Med Int Health 4: 454–467.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1969 | 1373 | 408 |
| Full Text Views | 805 | 19 | 0 |
| PDF Downloads | 306 | 12 | 0 |
