The Effect of Text Message Reminders to Health Workers on Quality of Care for Malaria, Pneumonia, and Diarrhea in Malawi: A Cluster-Randomized, Controlled Trial

Laura C. Steinhardt Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;

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Don P. Mathanga Malaria Alert Centre, College of Medicine, Blantyre, Malawi;

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Dyson Mwandama Malaria Alert Centre, College of Medicine, Blantyre, Malawi;

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Humphreys Nsona Ministry of Health, Lilongwe, Malawi;

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Dubulao Moyo Ministry of Health, Lilongwe, Malawi;

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Austin Gumbo Ministry of Health, Lilongwe, Malawi;

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Miwako Kobayashi Respiratory Diseases Branch, Division of Bacterial Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia;

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Ruth Namuyinga Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;

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Monica P. Shah Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;

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Andy Bauleni Malaria Alert Centre, College of Medicine, Blantyre, Malawi;

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Peter Troell US President’s Malaria Initiative, Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Lilongwe, Malawi;

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Dejan Zurovac KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya;
Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

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Alexander K. Rowe Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;

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The use of mobile technologies in medicine, or mHealth, holds promise to improve health worker (HW) performance, but evidence is mixed. We conducted a cluster-randomized controlled trial to evaluate the effect of text message reminders to HWs in outpatient health facilities (HFs) on quality of care for malaria, pneumonia, and diarrhea in Malawi. After a baseline HF survey (2,360 patients) in January 2015, 105 HFs were randomized to three arms: 1) text messages to HWs on malaria case management; 2) text messages to HWs on malaria, pneumonia, and diarrhea case management (latter two for children < 5 years); and 3) control arm (no messages). Messages were sent beginning April 2015 twice daily for 6 months, followed by an endline HF survey (2,536 patients) in November 2015. An intention-to-treat analysis with difference-in-differences binomial regression modeling was performed. The proportion of patients with uncomplicated malaria managed correctly increased from 42.8% to 59.6% in the control arm, from 43.7% to 55.8% in arm 1 (effect size −4.7%-points, 95% confidence interval (CI): −18.2, 8.9, P = 0.50) and from 30.2% to 50.9% in arm 2 (effect size 3.9%-points, 95% CI: −14.1, 22.0, P = 0.67). Prescription of first-line antibiotics to children < 5 years with clinically defined pneumonia increased in all arms, but decreased in arm 2 (effect size −4.1%-points, 95% CI: −42.0, 33.8, P = 0.83). Prescription of oral rehydration solution to children with diarrhea declined slightly in all arms. We found no significant improvements in malaria, pneumonia, or diarrhea treatment after HW reminders, illustrating the importance of rigorously testing new interventions before adoption.

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Author Notes

Address correspondence to Laura C. Steinhardt, Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30329. E-mail: lsteinhardt@cdc.gov

Financial support: This work was funded by the U.S. President’s Malaria Initiative (PMI) through a cooperative agreement with the Malaria Alert Centre in Malawi.

Disclaimer: The opinions expressed in this article are those of the authors and do not necessarily represent the views of the U.S. Centers for Disease Control and Prevention. This study protocol was approved by the Malawi College of Medicine (COMREC approval P.11/13/1488) and by the U.S. Centers for Disease Control and Prevention Institutional Review Board and registered with clinicaltrials.gov (NCT02645513). Written informed consent was obtained from all patients (or caregivers for patients < 18 years of age) and assent from those aged 7–17 years for exit interviews. Written informed consent was obtained from HWs for interviews and participation in the trial. If a patient enrolled in the survey reported fever or had a measured axillary temperature ≥ 37.5°C and had not been prescribed antimalarials by facility HWs, survey clinicians did a malaria RDT (SD Bioline malaria Pf, Standard Diagnostics, Inc, Giheng-ku, Republic of Korea) and gave antimalarials if the RDT was positive.

Authors’ addresses: Laura C. Steinhardt, Ruth Namuyinga, Monica P. Shah, and Alexander K. Rowe, Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, GA, E-mails: iyp6@cdc.gov, rnamuyinga@gmail.com, hyy9@cdc.gov, and axr9@cdc.gov. Don P. Mathanga, Dyson Mwandama, and Andy Bauleni, Malaria Alert Centre, College of Medicine, Blantyre, Malawi, E-mails: dmathang@mac.medcol.mw, dmwandama@gmail.com, and abauleni@mac.medcol.mw. Humphreys Nsona, Dubulao Moyo, and Austin Gumbo, Ministry of Health, Lilongwe, Malawi, E-mails: hnsona@gmail.com, dubulaomoyo@yahoo.com, and aagumbo@yahoo.co.uk. Miwako Kobayashi, Respiratory Diseases Branch, Division of Bacterial Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, E-mail: ydk3@cdc.gov. Peter Troell, US President’s Malaria Initiative, Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Lilongwe, Malawi, E-mail: vht9@cdc.gov. Dejan Zurovac, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya and Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK, E-mail: dzurovac@kemri-wellcome.org.

  • 1.

    World Health Organization, 2011. mHealth: New Horizons for Health through Mobile Technologies. GOf eHealth, ed. Geneva, Switzerland: WHO.

  • 2.

    Zurovac D, Talisuna AO, Snow RW, 2012. Mobile phone text messaging: tool for malaria control in Africa. PLoS Med 9: e1001176.

  • 3.

    Afrobarometer, 2016. Building on Progress: Infrastructure Development Still a Major Challenge in Africa, Dispatch No. 69. Available at: http://afrobarometer.org/sites/default/files/publications/Dispatches/ab_r6_dispatchno69_infrastructure_remains_challenge_en.pdf. Accessed October 6, 2017.

  • 4.

    Gurol-Urganci I, de Jongh T, Vodopivec-Jamsek V, Atun R, Car J, 2013. Mobile phone messaging reminders for attendance at healthcare appointments. Cochrane Database Syst Rev 12: CD007458.

    • Search Google Scholar
    • Export Citation
  • 5.

    de Jongh T, Gurol-Urganci I, Vodopivec-Jamsek V, Car J, Atun R, 2012. Mobile phone messaging for facilitating self-management of long-term illnesses. Cochrane Database Syst Rev 12: CD007459.

    • Search Google Scholar
    • Export Citation
  • 6.

    Gurol-Urganci I, de Jongh T, Vodopivec-Jamsek V, Car J, Atun R, 2012. Mobile phone messaging for communicating results of medical investigations. Cochrane Database Syst Rev 6: CD007456.

    • Search Google Scholar
    • Export Citation
  • 7.

    Vodopivec-Jamsek V, de Jongh T, Gurol-Urganci I, Atun R, Car J, 2012. Mobile phone messaging for preventive health care. Cochrane Database Syst Rev 12: CD007457.

    • Search Google Scholar
    • Export Citation
  • 8.

    Free C, Phillips G, Galli L, Watson L, Felix L, Edwards P, Patel V, Haines A, 2013. The effectiveness of mobile-health technology-based health behaviour change or disease management interventions for health care consumers: a systematic review. PLoS Med 10: e1001362.

    • Search Google Scholar
    • Export Citation
  • 9.

    Agarwal S, Perry HB, Long LA, Labrique AB, 2015. Evidence on feasibility and effective use of mHealth strategies by frontline health workers in developing countries: systematic review. Trop Med Int Health 20: 10031014.

    • Search Google Scholar
    • Export Citation
  • 10.

    Zurovac D, Sudoi RK, Akhwale WS, Ndiritu M, Hamer DH, Rowe AK, Snow RW, 2011. The effect of mobile phone text-message reminders on Kenyan health workers' adherence to malaria treatment guidelines: a cluster randomised trial. Lancet 378: 795803.

    • Search Google Scholar
    • Export Citation
  • 11.

    Jones CO, Wasunna B, Sudoi R, Githinji S, Snow RW, Zurovac D, 2012. “Even if you know everything you can forget”: health worker perceptions of mobile phone text-messaging to improve malaria case-management in Kenya. PLoS One 7: e38636.

    • Search Google Scholar
    • Export Citation
  • 12.

    Zurovac D, Larson BA, Sudoi RK, Snow RW, 2012. Costs and cost-effectiveness of a mobile phone text-message reminder programmes to improve health workers’ adherence to malaria guidelines in Kenya. PLoS One 7: e52045.

    • Search Google Scholar
    • Export Citation
  • 13.

    Chen Y, Yang K, Jing T, Tian J, Shen X, Xie C, Ma B, Liu Y, Yao L, Cao X, 2014. Use of text messages to communicate clinical recommendations to health workers in rural China: a cluster-randomized trial. Bull World Health Organ 92: 474481.

    • Search Google Scholar
    • Export Citation
  • 14.

    Bruxvoort K, Festo C, Kalolella A, Cairns M, Lyaruu P, Kenani M, Kachur SP, Goodman C, Schellenberg D, 2014. Cluster randomized trial of text message reminders to retail staff in tanzanian drug shops dispensing artemether-lumefantrine: effect on dispenser knowledge and patient adherence. Am J Trop Med Hyg 91: 844853.

    • Search Google Scholar
    • Export Citation
  • 15.

    Friedman W, Woodman B, Chatterji M, 2015. Can mobile phone messages to drug sellers improve treatment of childhood diarrhoea?—A randomized controlled trial in Ghana. Health Policy Plan 30 (Suppl 1): i8292.

    • Search Google Scholar
    • Export Citation
  • 16.

    Tomlinson M, Rotheram-Borus MJ, Swartz L, Tsai AC, 2013. Scaling Up mHealth: where is the evidence? PLoS Med 10: e1001382.

  • 17.

    van Heerden A, Tomlinson M, Swartz L, 2012. Point of care in your pocket: a research agenda for the field of m-health. Bull World Health Organ 90: 393394.

    • Search Google Scholar
    • Export Citation
  • 18.

    National Malaria Control Programme Malawi and ICF International, 2014. Malawi Malaria Indicator Survey (MIS) 2014. Lilongwe, Malawi and Rockville, MD: International NaI.

    • Search Google Scholar
    • Export Citation
  • 19.

    President’s Malaria Initiative, 2017. Malawi Malaria Operational Plan FY 2018. Washington, DC.

  • 20.

    Mace KE, Mwandama D, Jafali J, Luka M, Filler SJ, Sande J, Ali D, Kachur SP, Mathanga DP, Skarbinski J, 2011. Adherence to treatment with artemether-lumefantrine for uncomplicated malaria in rural Malawi. Clin Infect Dis 53: 772779.

    • Search Google Scholar
    • Export Citation
  • 21.

    Bruxvoort K, Kalolella A, Cairns M, Festo C, Kenani M, Lyaruu P, Kachur SP, Schellenberg D, Goodman C, 2015. Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy? Malar J 14: 87.

    • Search Google Scholar
    • Export Citation
  • 22.

    Namuyinga RJ et al. 2017. Health worker adherence to malaria treatment guidelines at outpatient health facilities in southern Malawi following implementation of universal access to diagnostic testing. Malar J 16: 40.

    • Search Google Scholar
    • Export Citation
  • 23.

    Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, Lawn JE, Cousens S, Mathers C, Black RE, 2016. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals. Lancet 388: 30273035.

    • Search Google Scholar
    • Export Citation
  • 24.

    The World Health Organization, 2014. Integrated Management of Childhood Illness Chart Booklet. Geneva, Switzerland: WHO.

  • 25.

    Johansson EW, Nsona H, Carvajal-Aguirre L, Amouzou A, Hildenwall H, 2017. Determinants of Integrated Management of Childhood Illness (IMCI) non-severe pneumonia classification and care in Malawi health facilities: analysis of a national facility census. J Glob Health 7: 020408.

    • Search Google Scholar
    • Export Citation
  • 26.

    Kobayashi M, Mwandama D, Nsona H, Namuyinga RJ, Shah MP, Bauleni A, Vanden Eng J, Rowe AK, Mathanga DP, Steinhardt LC, 2017. Quality of case management for pneumonia and diarrhea among children seen at health facilities in southern Malawi. Am J Trop Med Hyg 96: 11071116.

    • Search Google Scholar
    • Export Citation
  • 27.

    Mzilahowa T, Hastings IM, Molyneux ME, McCall PJ, 2012. Entomological indices of malaria transmission in Chikhwawa district, Southern Malawi. Malar J 11: 380.

    • Search Google Scholar
    • Export Citation
  • 28.

    The World Health Organization, 2017. Country Cooperation Strategy at a Glance: Malawi. Available at: http://apps.who.int/iris/bitstream/10665/136935/1/ccsbrief_mwi_en.pdf. Accessed December 1, 2017.

  • 29.

    National Malaria Control Programme, 2013. Guidelines for the treatment of malaria in Malawi. Lilongwe, Malawi: Ministry of Health.

  • 30.

    Malawi Ministry of Health, 2013. Integrated Management of Childhood Illness Chartbook. Lilongwe, Malawi: Ministry of Health.

  • 31.

    Steinhardt LC, Chinkhumba J, Wolkon A, Luka M, Luhanga M, Sande J, Oyugi J, Ali D, Mathanga D, Skarbinski J, 2014. Quality of malaria case management in Malawi: results from a nationally representative health facility survey. PLoS One 9: e89050.

    • Search Google Scholar
    • Export Citation
  • 32.

    Liang KY, Zeger SL, 1986. Longitudinal data analysis using generalized linear models. Biometrika 73: 1322.

  • 33.

    Spiegelman D, Hertzmark E, 2005. Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol 162: 199200.

  • 34.

    Suda KJ, Hicks LA, Roberts RM, Hunkler RJ, Taylor TH, 2014. Trends and seasonal variation in outpatient antibiotic prescription rates in the United States, 2006 to 2010. Antimicrob Agents Chemother 58: 27632766.

    • Search Google Scholar
    • Export Citation
  • 35.

    Holstiege J et al. 2014. Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study. BMC Pediatr 14: 174.

    • Search Google Scholar
    • Export Citation
  • 36.

    Shao AF, Rambaud-Althaus C, Swai N, Kahama-Maro J, Genton B, D’Acremont V, Pfeiffer C, 2015. Can smartphones and tablets improve the management of childhood illness in Tanzania? A qualitative study from a primary health care worker’s perspective. BMC Health Serv Res 15: 135.

    • Search Google Scholar
    • Export Citation
  • 37.

    Rambaud-Althaus C, Shao A, Samaka J, Swai N, Perri S, Kahama-Maro J, Mitchell M, D’Acremont V, Genton B, 2017. Performance of health workers using an electronic algorithm for the management of childhood illness in Tanzania: a pilot implementation study. Am J Trop Med Hyg 96: 249257.

    • Search Google Scholar
    • Export Citation
  • 38.

    Rambaud-Althaus C, Althaus F, Genton B, D’Acremont V, 2015. Clinical features for diagnosis of pneumonia in children younger than 5 years: a systematic review and meta-analysis. Lancet Infect Dis 15: 439450.

    • Search Google Scholar
    • Export Citation
  • 39.

    Haque F et al. 2017. Evaluation of a smartphone decision-support tool for diarrheal disease management in a resource-limited setting. PLoS Negl Trop Dis 11: e0005290.

    • Search Google Scholar
    • Export Citation
  • 40.

    Keitel K et al. 2017. A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): a randomized, controlled non-inferiority trial. PLoS Med 14: e1002411.

    • Search Google Scholar
    • Export Citation
  • 41.

    Barrington J, Wereko-Brobby O, Ward P, Mwafongo W, Kungulwe S, 2010. SMS for life: a pilot project to improve anti-malarial drug supply management in rural Tanzania using standard technology. Malar J 9: 298.

    • Search Google Scholar
    • Export Citation
  • 42.

    Ateudjieu J, Stoll B, Nguefack-Tsague G, Tchangou C, Genton B, 2014. Vaccines safety; effect of supervision or SMS on reporting rates of adverse events following immunization (AEFI) with meningitis vaccine (MenAfriVac): a randomized controlled trial. Vaccine 32: 56625668.

    • Search Google Scholar
    • Export Citation
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