Case Report: Diagnosis of Cryptosporidiosis in Renal Transplantation in a Low-Prevalence Setting

Shuwei Zheng Department of Infectious Diseases, Singapore General Hospital, Singapore;

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Kwan Ki Karrie Ko Department of Microbiology, Singapore General Hospital, Singapore;

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Kian Sing Chan Department of Molecular Pathology, Singapore General Hospital, Singapore

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Indumathi Venkatachalam Department of Infectious Diseases, Singapore General Hospital, Singapore;

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In high prevalence settings, cryptosporidiosis is commonly implicated as a cause of a gastroenteritis syndrome in the organ transplant population. Stool microscopy is predominant diagnostic modality. Therapeutic options in this group of patients are limited, making their management exceptionally challenging. We describe a case of a renal transplant recipient with cryptosporidiosis confirmed by the stool FilmArray gastrointestinal panel (GIP) nucleic acid-based assay and stool microscopy, describe our institutional experience in diagnosing cryptosporidiosis in a low-prevalence setting, and review the available literature on management of this condition in the organ transplant population. In a low-prevalence setting, the GIP can serve as a rapid screening tool in the diagnosis of cryptosporidiosis.

Author Notes

Address correspondence to Shuwei Zheng, Department of Infectious Diseases, Singapore General Hospital, Outram Rd., Singapore 169608. E-mail: zheng.shuwei@singhealth.com.sg

Authors’ addresses: Shuwei Zheng and Indumathi Venkatachalam, Department of Infectious Diseases, Singapore General Hospital, Singapore, E-mails: zheng.shuwei@singhealth.com.sg and indumathi.venkatachalam@singhealth.com.sg. Kwan Ki Karrie Ko, Department of Microbiology, Singapore General Hospital, Singapore, E-mail: karrie.ko.k.k@sgh.com.sg. Kian Sing Chan, Department of Molecular Pathology, Singapore General Hospital, Singapore, E-mail: chan.kian.sing@singhealth.com.sg.

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