World Health Organization, 2013. WHO Expert Consultation on Rabies: Second Report. World Health Organization Technical Report Series 982. Geneva, Switzerland: WHO.
Sudarshan MK, Madhusudana SN, Mahendra BJ, Rao NS, Ashwath Narayana DH, Abdul Rahman S, Meslin FX, Lobo D, Ravikumar K, Gangaboraiah, 2007. Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey. Int J Infect Dis 11: 29–35.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J, 2013. Human rabies: neuropathogenesis, diagnosis, and management. Lancet Neurol 12: 498–513.
Fooks AR et al. 2017. Rabies. Nat Rev Dis Primers 3: 17091.
Mani RS, Madhusudana SN, Mahadevan A, Reddy V, Belludi AY, Shankar SK, 2014. Utility of real-time Taqman PCR for antemortem and postmortem diagnosis of human rabies. J Med Virol 86: 1804–1812.
Ashwath Narayana DH et al. 2014. Safety and immunogenicity study of a new purified chick embryo cell rabies vaccine Vaxirab-N (Pitman–Moore strain) manufactured in India. Hum Vaccin Immunother 10: 120–125.
Mani RS, Willoughby RE, 2017. Human rabies in south Asia. Singh SK, ed. Neglected Tropical Diseases–South Asia. Neglected Tropical Diseases. Cham, Switzerland: Springer, 349–371.
Mani RS, 2016. Human rabies survivors in India: an emerging paradox? PLoS Negl Trop Dis 10: e0004774.
Mani RS, Anand AM, Madhusudana SN, 2016. Human rabies in India: an audit from a rabies diagnostic laboratory. Trop Med Int Health 21: 556–563.
Willoughby RE Jr., 2015. Rabies: rare human infection–common questions. Infect Dis Clin North Am 29: 637–650.
Madhusudana SN, Sukumaran SM, 2008. Antemortem diagnosis and prevention of human rabies. Ann Indian Acad Neurol 11: 3–12.
Willoughby RE Jr., Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, Chusid MJ, Rupprecht CE, 2005. Survival after treatment of rabies with induction of coma. N Engl J Med 352: 2508–2514.
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Rabies, a zoonotic viral encephalitis, continues to be a serious public health problem in India and several other countries in Asia and Africa. Survival is rarely reported in rabies, which is considered to be almost universally fatal. We report the clinical and radiological findings of eight patients with laboratory-confirmed rabies who survived the illness. With the exception of one patient who recovered with mild sequelae, all survivors had poor functional outcomes. The reported survival from rabies in recent years may reflect an increased awareness of the disease and greater access to better critical care facilities in rabies-endemic countries. Nonetheless, there is an urgent need to focus on preventive strategies to reduce the burden of this dreadful disease in rabies-endemic countries.
Authors’ addresses: Reeta S. Mani and Tina Damodar, Department of Neurovirology, WHO Collaborating Centre for Reference and Research in Rabies, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India, E-mails: drreeta@gmail.com and tinadamodar86@gmail.com. Divyashree S, Department of Infectious Diseases, MGM New Bombay Hospital, Mumbai, India, E-mail: doc.divyashree@gmail.com. Srikanth Domala, Ramesh Konanki, and Lokesh Lingappa, Department of Pediatric Neurology and Neurorehabilitation, Rainbow Children’s Hospital, Hyderabad and Secunderabad, Telangana, India, E-mails: srikanthji@gmail.com, rameshkonanki@gmail.com, and siriloki@gmail.com. Birendra Gurung, Department of Pediatrics, District Hospital Namchi, Namchi, India, E-mail: bgtamu71@gmail.com. Vilas Jadhav, Arya Child Epilepsy and Neurology Clinic, Kolhapur, India, E-mail: hribhavjadhav@gmail.com. Sathish Kumar Loganathan, Department of Child Health, Christian Medical College and Hospital, Vellore, India, E-mail: sathishloganathan82@gmail.com. Rajendra Salagare, Salagare Children and Eye Hospital, Chikodi, India, E-mail: drsalgare@yahoo.com. Priyash Tambi, Department of Pediatrics and Pediatric Intensive Care Unit, Seth G.S. Medical College and KEM Hospital, Mumbai, India, E-mail: priyashtambi@gmail.com.
World Health Organization, 2013. WHO Expert Consultation on Rabies: Second Report. World Health Organization Technical Report Series 982. Geneva, Switzerland: WHO.
Sudarshan MK, Madhusudana SN, Mahendra BJ, Rao NS, Ashwath Narayana DH, Abdul Rahman S, Meslin FX, Lobo D, Ravikumar K, Gangaboraiah, 2007. Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey. Int J Infect Dis 11: 29–35.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J, 2013. Human rabies: neuropathogenesis, diagnosis, and management. Lancet Neurol 12: 498–513.
Fooks AR et al. 2017. Rabies. Nat Rev Dis Primers 3: 17091.
Mani RS, Madhusudana SN, Mahadevan A, Reddy V, Belludi AY, Shankar SK, 2014. Utility of real-time Taqman PCR for antemortem and postmortem diagnosis of human rabies. J Med Virol 86: 1804–1812.
Ashwath Narayana DH et al. 2014. Safety and immunogenicity study of a new purified chick embryo cell rabies vaccine Vaxirab-N (Pitman–Moore strain) manufactured in India. Hum Vaccin Immunother 10: 120–125.
Mani RS, Willoughby RE, 2017. Human rabies in south Asia. Singh SK, ed. Neglected Tropical Diseases–South Asia. Neglected Tropical Diseases. Cham, Switzerland: Springer, 349–371.
Mani RS, 2016. Human rabies survivors in India: an emerging paradox? PLoS Negl Trop Dis 10: e0004774.
Mani RS, Anand AM, Madhusudana SN, 2016. Human rabies in India: an audit from a rabies diagnostic laboratory. Trop Med Int Health 21: 556–563.
Willoughby RE Jr., 2015. Rabies: rare human infection–common questions. Infect Dis Clin North Am 29: 637–650.
Madhusudana SN, Sukumaran SM, 2008. Antemortem diagnosis and prevention of human rabies. Ann Indian Acad Neurol 11: 3–12.
Willoughby RE Jr., Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, Chusid MJ, Rupprecht CE, 2005. Survival after treatment of rabies with induction of coma. N Engl J Med 352: 2508–2514.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 2202 | 1594 | 74 |
Full Text Views | 1141 | 42 | 6 |
PDF Downloads | 778 | 46 | 6 |