Author:
ProCite
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Reference Manager
BibTeX
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-
1.
Khuroo MS, Khuroo MS, Khuroo NS, 2016. Hepatitis E: discovery, global impact, control and cure. World J Gastroenterol 22: 7030–7045.
-
2.
Kamar N, Izopet J, Pavio N, Aggrawal R, Labrique A, Wedemeyer H, Dalton HR, 2017. Hepatitis E virus infection. Nat Rev Dis Primers 3: 17086.
-
3.
Ali G, Kumar M, Bali S, Wadhwa W, 2001. Hepatitis E associated immune thrombocytopaenia and membranous glomerulonephritis. Indian J Nephrol 11: 70–72.
-
4.
Pischke S, Hartl J, Pas SD, Lohse AW, Jacobs BC, Van der Eijk AA, 2017. Hepatitis E virus: infection beyond the liver? J Hepatol 66: 1082–1095.
-
5.
Dahl V, Wallenstein A, 2017. Self-reported infectious during international travel and notifiable infections among returning international travellers, Sweden, 2009–2013. PLoS One 12: e0181625.
-
6.
Patel I, Ching Companioni R, Bansal R, Vyas N, Catalano C, Aron J, Walfish A, 2016. Acute hepatitis E presenting with clinical feature of autoimmune hepatitis. J Community Hosp Intern Med Perspect 6: 33342.
-
7.
Sebode M, Pischke S, Lütgehetmann M, Polywka S, Quaas A, Lohse AW, Wege H, 2014. New foe treated with old guns—supportive role of steroids in the treatment of acute severe hepatitis E. BMC Gastroenterol 14: 191.
-
8.
Ebbeson RL, Schruiber RA, 2004. Diagnosing autoimmune hepatitis in children: is the international autoimmune hepatitis group scoring system useful? Clin Gastroenterol Hepatol 2: 935–940.
-
9.
Alvarez F et al. 1999. International autoimmune hepatitis group: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 31: 929–938.
-
10.
Hiejima E, Komatsu H, Sogo T, Inui A, Fujisawa T, 2011. Utility of simplified criteria for the diagnosis of autoimmune hepatitis in children. J Pediatr Gastroenterol Nutr 52: 470–473.
-
11.
Sugitani M et al. 2009. Detection of hepatitis E virus RNA and genotype in Bangladesh. J Gastroenterol Hepatol 24: 599–604.
-
12.
Zuckerman JN, 2003. Hepatitis E and the traveller. Travel Med Infect Dis 1: 73–76.
-
13.
Leder K et al. 2013. GeoSentinel surveillance of illness in returned travelers, 2007–2011. Ann Intern Med 158: 456–468.
-
14.
Heywood AE et al. 2016. The contribution of travellers visiting friends and relatives to notified infectious diseases in Australia: state-based enhanced surveillance. Epidemiol Infect 144: 3554–3563.
-
15.
Bradanini L, Youkee D, Fabris P, Roman L, Brunetti E, Giordani MT, 2017. Acute hepatitis E virus infection in a migrant population in north east Italy: a retrospective analysis. Travel Med Infect Dis 20: 37–42.
-
16.
Azman AS et al. 2017. High hepatitis E seroprevalence among displaced persons in South Sudan. Am J Trop Med Hyg 96: 1296–1301.
-
17.
Sadarangani SP, Lim PL, Vasoo S, 2017. Infectious diseases and migrant worker health in Singapore: a receiving country’s perspective. J Travel Med 24: tax014.
-
18.
Eick A et al. 2010. Hepatitis E seroprevalence and seroconversion among US military service members deployed to Afghanistan. J Infect Dis 202: 1302–1308.
-
19.
Teshale EH, 2017. Hepatitis E. Brunette GW, Kozarsky PE, eds. CDC Health Information for International Travel 2018. New York, NY: Oxford University Press.
-
20.
Mieli-Vergani G et al. 2009. Autoimmune hepatitis. J Pediatr Gastroenterol Nutr 49: 158–164.
-
21.
Arcos-Machancoses JV, Molera Busoms C, Julio Tatis E, Victoria Bovo M, Quintero Bernabeu J, Juamperez Goni J, Crujeiras Martinez V, Martin de Carpi J, 2018. Accuracy of the 2008 simplified criteria for the diagnosis of autoimmune hepatitis in children. Pediatr Gastroenterol Hepatol Nutr 21: 118–126.
-
22.
Vergani D, Choudhuri K, Bogdanos DP, Mieli-Vergani G, 2002. Pathogenesis of autoimmune hepatitis. Clin Liver Dis 6: 727–737.
-
23.
Pischke S et al. 2014. Increased HEV seroprevalence in patients with autoimmune hepatitis. PLoS One 9: e85330.
-
24.
Van Gerven NM, van der Eijk AA, Pas SD, Zaaijer HL, de Boer YS, Witte BI, van Nieuwkerk CM, Mulder CJ, Bouma G, de Man RA, 2016. Seroprevalence of hepatitis E virus in autoimmune hepatitis patients in The Netherlands. J Gastrointestin Liver Dis 25: 9–13.
-
25.
Vieira CL, Baldaia C, Fatela N, Ramalho F, Cardoso C, 2013. Case of acute hepatitis E with concomitant signs of autoimmunity. World J Hepatol 5: 152–155.
-
26.
Le Cann P, Tong MJ, Werneke J, Coursaget P, 1997. Detection of antibodies to hepatitis E virus in patients with autoimmune chronic active hepatitis and primary biliary cirrhosis. Scand J Gastroenterol 32: 387–389.
-
27.
Cook GC, Mulligan R, Sherlock S, 1971. Controlled prospective trial of corticosteroid therapy in active chronic hepatitis. Q J Med 40: 159–185.
-
28.
Wedemeyer H, Rybczynska J, Pischke S, Krawczynski K, 2013. Immunopathogenesis of hepatitis E virus infection. Semin Liver Dis 33: 71–78.
-
29.
Nagasaki F, Ueno Y, Mano Y, Igarashi T, Yahagi K, Niitsuma H, Okamoto H, Shimosegawa T, 2005. A patient with clinical features of acute hepatitis E viral infection and autoimmune hepatitis. Tohoku J Exp Med 206: 173–179.
-
30.
Verghese VP, Robinson JL, 2014. A systematic review of hepatitis E virus infection in children. Clin Infect Dis 59: 689–697.
-
31.
Ramachandran J, Ramakrishna B, Eapen CE, Abraham P, Zachariah UG, Jayram A, Mathews M, Kurian G, Mukopadhya A, Chandy G, 2008. Subacute hepatic failure due to hepatitis E. J Gastroenterol Hepatol 23: 879–882.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 774 | 553 | 87 |
| Full Text Views | 1164 | 11 | 0 |
| PDF Downloads | 736 | 8 | 0 |
Case Report: Acute Hepatitis E in a Pediatric Traveler Presenting with Features of Autoimmune Hepatitis: A Diagnostic and Therapeutic Challenge
Nathan Z. Minkoff
Nathan Z. Minkoff
Department of Pediatrics, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York;
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Kate Buzzi
Kate Buzzi
Department of Pediatrics, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York;
Division of Pediatric Gastroenterology, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York;
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York;
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Division of Pediatric Gastroenterology, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York;
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York;
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Alex K. Williamson
Alex K. Williamson
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York;
Department of Pathology, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York;
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Department of Pathology, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York;
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Stefan H. F. Hagmann
Stefan H. F. Hagmann
Department of Pediatrics, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York;
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York;
Division of Pediatric Infectious Diseases, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York
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Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York;
Division of Pediatric Infectious Diseases, Steven and Alexandra Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York
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Hepatitis E virus (HEV) is globally the most common cause of acute viral hepatitis. In industrialized countries, HEV infection can be seen in travelers returning from hyperendemic countries or in individuals at risk for autochthonous infection due to zoonotic exposure. Hepatitis E virus infection is often unrecognized and at times misdiagnosed because of nonspecific findings that can overlap with other causes of hepatitis, including autoimmune hepatitis (AIH). Although most cases of acute HEV infection resolve spontaneously and do not require treatment, life-threatening acute liver failure may occur in some cases. We discuss the case of an 8-year-old boy returning from Bangladesh with progressive acute liver injury and a clinical profile suggestive of AIH, who showed a favorable response to corticosteroid treatment before the diagnosis of an acute HEV infection could be established.
Author Notes
Authors’ addresses: Nathan Z. Minkoff, Department of Pediatrics, Steven and Alexandra Cohen Children’s Medical Center, New Hyde Park, NY, E-mail: nathan.minkoff@gmail.com. Kate Buzzi, Division of Pediatric Gastroenterology, Steven and Alexandra Cohen Children’s Medical Center, New Hyde Park, NY, E-mail: kbuzzi@northwell.edu. Alex K. Williamson, Department of Pathology, Steven and Alexandra Cohen Children’s Medical Center, New Hyde Park, NY, E-mail: awilliamson@northwell.edu. Stefan H. F. Hagmann, Division of Pediatric Infectious Diseases, Steven and Alexandra Cohen Children’s Medical Center, New Hyde Park, NY, E-mail: shagmann@northwell.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Khuroo MS, Khuroo MS, Khuroo NS, 2016. Hepatitis E: discovery, global impact, control and cure. World J Gastroenterol 22: 7030–7045.
-
2.
Kamar N, Izopet J, Pavio N, Aggrawal R, Labrique A, Wedemeyer H, Dalton HR, 2017. Hepatitis E virus infection. Nat Rev Dis Primers 3: 17086.
-
3.
Ali G, Kumar M, Bali S, Wadhwa W, 2001. Hepatitis E associated immune thrombocytopaenia and membranous glomerulonephritis. Indian J Nephrol 11: 70–72.
-
4.
Pischke S, Hartl J, Pas SD, Lohse AW, Jacobs BC, Van der Eijk AA, 2017. Hepatitis E virus: infection beyond the liver? J Hepatol 66: 1082–1095.
-
5.
Dahl V, Wallenstein A, 2017. Self-reported infectious during international travel and notifiable infections among returning international travellers, Sweden, 2009–2013. PLoS One 12: e0181625.
-
6.
Patel I, Ching Companioni R, Bansal R, Vyas N, Catalano C, Aron J, Walfish A, 2016. Acute hepatitis E presenting with clinical feature of autoimmune hepatitis. J Community Hosp Intern Med Perspect 6: 33342.
-
7.
Sebode M, Pischke S, Lütgehetmann M, Polywka S, Quaas A, Lohse AW, Wege H, 2014. New foe treated with old guns—supportive role of steroids in the treatment of acute severe hepatitis E. BMC Gastroenterol 14: 191.
-
8.
Ebbeson RL, Schruiber RA, 2004. Diagnosing autoimmune hepatitis in children: is the international autoimmune hepatitis group scoring system useful? Clin Gastroenterol Hepatol 2: 935–940.
-
9.
Alvarez F et al. 1999. International autoimmune hepatitis group: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 31: 929–938.
-
10.
Hiejima E, Komatsu H, Sogo T, Inui A, Fujisawa T, 2011. Utility of simplified criteria for the diagnosis of autoimmune hepatitis in children. J Pediatr Gastroenterol Nutr 52: 470–473.
-
11.
Sugitani M et al. 2009. Detection of hepatitis E virus RNA and genotype in Bangladesh. J Gastroenterol Hepatol 24: 599–604.
-
12.
Zuckerman JN, 2003. Hepatitis E and the traveller. Travel Med Infect Dis 1: 73–76.
-
13.
Leder K et al. 2013. GeoSentinel surveillance of illness in returned travelers, 2007–2011. Ann Intern Med 158: 456–468.
-
14.
Heywood AE et al. 2016. The contribution of travellers visiting friends and relatives to notified infectious diseases in Australia: state-based enhanced surveillance. Epidemiol Infect 144: 3554–3563.
-
15.
Bradanini L, Youkee D, Fabris P, Roman L, Brunetti E, Giordani MT, 2017. Acute hepatitis E virus infection in a migrant population in north east Italy: a retrospective analysis. Travel Med Infect Dis 20: 37–42.
-
16.
Azman AS et al. 2017. High hepatitis E seroprevalence among displaced persons in South Sudan. Am J Trop Med Hyg 96: 1296–1301.
-
17.
Sadarangani SP, Lim PL, Vasoo S, 2017. Infectious diseases and migrant worker health in Singapore: a receiving country’s perspective. J Travel Med 24: tax014.
-
18.
Eick A et al. 2010. Hepatitis E seroprevalence and seroconversion among US military service members deployed to Afghanistan. J Infect Dis 202: 1302–1308.
-
19.
Teshale EH, 2017. Hepatitis E. Brunette GW, Kozarsky PE, eds. CDC Health Information for International Travel 2018. New York, NY: Oxford University Press.
-
20.
Mieli-Vergani G et al. 2009. Autoimmune hepatitis. J Pediatr Gastroenterol Nutr 49: 158–164.
-
21.
Arcos-Machancoses JV, Molera Busoms C, Julio Tatis E, Victoria Bovo M, Quintero Bernabeu J, Juamperez Goni J, Crujeiras Martinez V, Martin de Carpi J, 2018. Accuracy of the 2008 simplified criteria for the diagnosis of autoimmune hepatitis in children. Pediatr Gastroenterol Hepatol Nutr 21: 118–126.
-
22.
Vergani D, Choudhuri K, Bogdanos DP, Mieli-Vergani G, 2002. Pathogenesis of autoimmune hepatitis. Clin Liver Dis 6: 727–737.
-
23.
Pischke S et al. 2014. Increased HEV seroprevalence in patients with autoimmune hepatitis. PLoS One 9: e85330.
-
24.
Van Gerven NM, van der Eijk AA, Pas SD, Zaaijer HL, de Boer YS, Witte BI, van Nieuwkerk CM, Mulder CJ, Bouma G, de Man RA, 2016. Seroprevalence of hepatitis E virus in autoimmune hepatitis patients in The Netherlands. J Gastrointestin Liver Dis 25: 9–13.
-
25.
Vieira CL, Baldaia C, Fatela N, Ramalho F, Cardoso C, 2013. Case of acute hepatitis E with concomitant signs of autoimmunity. World J Hepatol 5: 152–155.
-
26.
Le Cann P, Tong MJ, Werneke J, Coursaget P, 1997. Detection of antibodies to hepatitis E virus in patients with autoimmune chronic active hepatitis and primary biliary cirrhosis. Scand J Gastroenterol 32: 387–389.
-
27.
Cook GC, Mulligan R, Sherlock S, 1971. Controlled prospective trial of corticosteroid therapy in active chronic hepatitis. Q J Med 40: 159–185.
-
28.
Wedemeyer H, Rybczynska J, Pischke S, Krawczynski K, 2013. Immunopathogenesis of hepatitis E virus infection. Semin Liver Dis 33: 71–78.
-
29.
Nagasaki F, Ueno Y, Mano Y, Igarashi T, Yahagi K, Niitsuma H, Okamoto H, Shimosegawa T, 2005. A patient with clinical features of acute hepatitis E viral infection and autoimmune hepatitis. Tohoku J Exp Med 206: 173–179.
-
30.
Verghese VP, Robinson JL, 2014. A systematic review of hepatitis E virus infection in children. Clin Infect Dis 59: 689–697.
-
31.
Ramachandran J, Ramakrishna B, Eapen CE, Abraham P, Zachariah UG, Jayram A, Mathews M, Kurian G, Mukopadhya A, Chandy G, 2008. Subacute hepatic failure due to hepatitis E. J Gastroenterol Hepatol 23: 879–882.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 774 | 553 | 87 |
| Full Text Views | 1164 | 11 | 0 |
| PDF Downloads | 736 | 8 | 0 |