Enhancement of Stibophen (Fuadin®) Activity against Schistosoma Mansoni in Mice by Feeding Purified Semi-Synthetic Diets

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  • National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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The efficacy of stibophen (Fusdin®) for killing mature Schistosoma mansoni was compared in mice on a standard commercial ration and in others on semi-synthetic diets. In several tests in which mice received intraperitoneally a dose of 100 mg/kg daily for 8 days, it was estimated that the drug was from 4 to 16 times more effective in eliminating the schistosomes in the animals on the semi-synthetic diets than in those on the crude commercial ration.

Author Notes

Laboratory of Parasite Chemotherapy.

Laboratory of Parasitic Diseases.

With the technical assistance of R. H. Duvall, O. Kline, and W. Blodgett.