N,N′-bis(Dichloroacetyl)Diamines as Amebicidal Agents

D. A. Berberian Sterling-Winthrop Research Institute, Rensselaer, New York

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R. G. Slighter Sterling-Winthrop Research Institute, Rensselaer, New York

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E. W. Dennis Sterling-Winthrop Research Institute, Rensselaer, New York

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DOI:
https://doi.org/10.4269/ajtmh.1961.10.503
Volume/Issue:
Volume 10: Issue 4
Page(s):
503–509
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Summary

The in vitro and in vivo amebicidal activities of eight new synthetic N,N′-bis(dichloroacetyl)diamines are reported. These compounds are amebicidal in vitro against Entamoeba histolytica in concentrations of 1 part in 1 million to as low as 1 part in 50 million. In vivo amebicidal activity was evaluated in hamsters spontaneously infected with Entamoeba criceti. The compounds discussed are highly amebicidal; their calculated ED50 values are in the range of 0.7 to 2.5 mg/kg/day when given for 4 days.

Author Notes

Published Online:
Jul 1961
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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