Adaptation of Dengue Virus to the Hamster

Gordon MeiklejohnViral and Rickettsial Disease Laboratory, California State Department of Public Health

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Beatrice EnglandViral and Rickettsial Disease Laboratory, California State Department of Public Health

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Edwin H. LennetteViral and Rickettsial Disease Laboratory, California State Department of Public Health

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Summary

By serial intracerebral passages, the New Guinea C and Hawaiian strains of dengue virus were adapted to growth in hamsters of 2–5 days of age.

Dengue virus should no longer be described, without qualification, as non-pathogenic for the hamster.

Additional data are presented showing that the New Guinea C and Hawaiian strains represent 2 different immunologic types of dengue virus.

Author Notes

1392 University Avenue, Berkeley 2, California.

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