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The in Vitro Activity of Certain Antimalarials against Erythrocytic Forms of Plasmodium Gallinaceum
D. Jane Taylor
D. Jane Taylor
National Institutes of Health, National Microbiological Institute, Bethesda 14, Maryland
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Edward S. Josephson
Edward S. Josephson
National Institutes of Health, National Microbiological Institute, Bethesda 14, Maryland
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Joseph Greenberg
Joseph Greenberg
National Institutes of Health, National Microbiological Institute, Bethesda 14, Maryland
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G. Robert Coatney
G. Robert Coatney
National Institutes of Health, National Microbiological Institute, Bethesda 14, Maryland
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Summary
A series of compounds was tested for antimalarial activity in vitro against the erythrocytic forms of Plasmodium gallinaceum. Chloroquine, quinacrine, quinine, and the naphthoquinone, SN 12,320, were active at concentrations approximating those found in the blood of adequately treated chicks. Pamaquine was relatively inactive in vitro, but when administered to chickens gave rise to active metabolic intermediates. Sulfadiazine, metachloridine, chlorguanide, and two of its metabolic intermediates from monkeys, a number of 2,4-diaminopyrimidines, and a 2,4-diaminopterin were relatively inactive in vitro.
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| Past two years | Past Year | Past 30 Days | |
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