Volume 61, Issue 1_Supplement
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A retrospective study was made of clinical records to determine parasitemia and episodes of fever of 59 patients reinfected with for treatment of neurosyphilis, which was considered standard medical care at the time. Records were collected at the National Institutes of Health laboratories in Columbia, South Carolina and Milledgeville, Georgia during the period 1940 to 1963. Nineteen patients were infected via the bites of , , or mosquitoes; the median prepatent period was 11.5 days. It was evident that clinical immunity, as measured by the frequency of fever, particularly high intensity fever (≥ 104°F), was increased following reinfection. The parasitologic immunity, as measured by the frequency of asexual parasite counts and gametocyte counts, was also evident. In general, in secondary infections with homologous and/or heterologous strains of , fever episodes ≥ 101¿ of and ≥ 104°F were reduced in number, parasitemia was reduced, and gametocyte production was reduced. However, despite long courses of parasitemia during their primary infections, most patients developed fever and, in some cases, high-density parasitemia and gametocytemia following reinfection. The intensity of the secondary response did not appear to be associated with the length of the previous course of parasitemia. In addition, current infection with heterologous strain parasites did not prevent the development of fever or higher density parasite counts following imposition of the new strain of parasite.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Collins WE, Jeffery GM, , 1999. A retrospective examination of sporozoite- and trophozoite-induced infections with Plasmodium falciparum: development of parasitologic and clinical immunity during primary infection. Am J Trop Med Hyg 61: (suppl): 419. [Crossref] [Google Scholar]
  2. Young MD, Hardman NF, Burgess RW, Frohne WC, Sabrosky CW, , 1948. The infectivity of native malarias in South Carolina to Anopheles quadrimaculatus . Am J Trop Med 28: 303311. [Google Scholar]
  3. Jeffery GM, Eyles DE, Young MD, , 1950. The comparative susceptibility of Anopheles quadrimaculatus and two strains of Anopheles albimanus to a Panama strain of Plasmodium falciparum . J Natl Malaria Soc 9: 349355. [Google Scholar]
  4. Eyles DE, Young MD, , 1950. The comparative susceptibility of Anopheles albimanus and Anopheles quadrimaculatus to a South Carolina strain of Plasmodium falciparum . J Infect Dis 87: 189193. [Crossref] [Google Scholar]
  5. Young MD, Moore DV, , 1961. Chloroquine resistance in Plasmodium falciparum . Am J Trop Med Hyg 10: 317320. [Google Scholar]
  6. Young MD, Contacis PG, Stitcher JE, Millar JW, , 1963. Drug resistance in Plasmodium falciparum from Thailand. Am J Trop Med Hyg 12: 305314. [Google Scholar]
  7. Boyd MF, , 1945. On difficulties arising in the experimental propagation of falciparum malaria. Am J Trop Med 25: 293306. [Google Scholar]
  8. Earle WC, Perez M, , 1932. Enumeration of parasites in the blood of malarial patients. J Lab Clin Med 17: 11241130. [Google Scholar]
  9. Mayne B, Young MD, , 1941. The technique of induced malaria as used in the South Carolina State Hospital. Venereal Dis Information 22: 271276. [Google Scholar]
  10. Collins WE, Collins GM, , 1962. Methods and techniques for the handling of mosquitoes in human and animal malaria studies. Proceedings of the 49th Annual Meeting of the New Jersey Mosquito Extermination Association, 188195. [Google Scholar]

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error