1921
Volume 88, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Children with traditionally defined cerebral malaria (CM) can be subcategorized by the presence or absence of malaria retinopathy. We retrospectively reviewed the seasonal pattern of retinopathy status in patients admitted with CM in Blantyre, Malawi from 1997 to 2010. The proportion of children with CM who were retinopathy-positive was significantly greater during the peak seasonal rains when the community incidence of uncomplicated malaria is higher. This finding supports the hypothesis that retinopathy-negative and retinopathy-positive CM categories have different underlying etiologies.

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2017-11-22
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References

  1. World Health Organization Communicable Diseases Cluster, 2000. Severe falciparum malaria. World Health Organization Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 94 (Suppl 1): S1S90.
  2. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, Jha P, Campbell H, Walker CF, Cibulskis R, Eisele T, Liu L, Mathers C, Child Health Epidemiology Reference Group of WHO and UNICEF; , 2010. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 375: 19691987.[Crossref]
  3. Roca-Feltrer A, Carneiro I, Armstrong Schellenberg JR, , 2008. Estimates of the burden of malaria morbidity in Africa in children under the age of 5 years. Trop Med Int Health 13: 771783.[Crossref]
  4. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, , 1989. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 71: 441459.
  5. Birbeck GL, Molyneux ME, Kaplan PW, Seydel KB, Chimalizeni YF, Kawaza K, Taylor TE, , 2010. Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study. Lancet Neurol 9: 11731181.[Crossref]
  6. Postels DG, Taylor TE, Molyneux M, Mannor K, Kaplan PW, Seydel KB, Chimalizeni YF, Kawaza K, Birbeck GL, , 2012. Neurologic outcomes in retinopathy-negative cerebral malaria survivors. Neurology 79: 12681272.[Crossref]
  7. O'Meara WP, Bejon P, Mwangi TW, Okiro EA, Peshu N, Snow RW, Newton CR, Marsh K, , 2008. Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya. Lancet 372: 15551562.[Crossref]
  8. Taylor TE, Fu WJ, Carr RA, Whitten RO, Mueller JS, Fosiko NG, Lewallen S, Liomba NG, Molyneux ME, , 2004. Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med 10: 143145.[Crossref]
  9. Lewallen S, Taylor TE, Molyneux ME, Wills BA, Courtright P, , 1993. Ocular fundus findings in Malawian children with cerebral malaria. Ophthalmology 100: 857861.[Crossref]
  10. Beare NA, Glover SJ, Molyneux M, , 2009. Malarial retinopathy in cerebral malaria. Am J Trop Med Hyg 80: 171.
  11. Beare NA, Taylor TE, Harding SP, Lewallen S, Molyneux ME, , 2006. Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am J Trop Med Hyg 75: 790797.
  12. Postels DG, Birbeck GL, , 2011. Children with retinopathy-negative cerebral malaria: a pathophysiological puzzle. Pediatr Infect Dis J 30: 953956.[Crossref]
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  • Received : 06 Jul 2012
  • Accepted : 16 Oct 2012

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