1921
Volume 88, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Understanding the pathogenesis of malaria is challenging. We hypothesized that susceptibility to -induced thrombocytopenia could be associated with polymorphisms on relevant platelet membrane integrins: integrin α2 (C807T), and integrin β3 (T1565C). Although β3 polymorphism was not related with malaria, α2 807T carriers, which show high levels of integrin α2β1, had a higher probability for severe thrombocytopenia than wild-type carriers. This evidence of the association of integrin polymorphism and morbidity was further demonstrated by a moderate but significant correlation between clinical disease and surface levels of the integrin α2β1.

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  • Received : 11 May 2012
  • Accepted : 01 Nov 2012
  • Published online : 06 Feb 2013

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