1921
Volume 87, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The question of whether (Ct) is a cofactor for human (HPV) in cervical carcinogenesis is still controversial. We conducted a molecular detection study of both infections in 622 Brazilian women, including 252 women with different grades of abnormal cervical cytology and cervical cancer (CC; cases) and 370 women with normal cytology (controls). Although Ct infection did not seem related to CC carcinogenicity, women with abnormal cytology had a significant high rate of Ct infection. Therefore, it is important to adopt protocols for diagnosis and treatment of this bacterium in conjunction with screening for CC in this population.

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References

  1. Kling M, Zeichner JA, , 2010. The role of the Human papillomavirus (HPV) vaccine in developing countries. Int J Dermatol 49: 377379.[Crossref] [Google Scholar]
  2. Jemal A, Bray F, Center MM, Ferlay J, War E, Forman D, , 2011. Global cancer statistics. CA Cancer J Clin 61: 6990.[Crossref] [Google Scholar]
  3. Solomon D, Nayar R, , 2005. Bethesda System for cervical-vaginal cytology. Rio de Janeiro, RJ: Revinter, 6787. [Google Scholar]
  4. Instituto Nacional de Câncer, 2012. Estimativa 2012 de incidência de câncer no Brasil. Available at: http://www.inca.gov.br/estimativa/2012/tabelaestados.asp?UF=BR. Accessed March 1, 2012. [Google Scholar]
  5. Bodily J, Laimins LA, , 2011. Persistence of Human papillomavirus infection: keys to malignant progression. Trends Microbiol 19: 3339.[Crossref] [Google Scholar]
  6. Lizano M, Berumen J, García-Carrancá A, , 2009. HPV-related carcinogenesis: basic concepts, viral types and variants. Arch Med Res 40: 428434.[Crossref] [Google Scholar]
  7. Miller WC, Ko EM, , 2011. Does the chlamydial infection increase the risk of cervical dysplasia? Sex Transm Infect 87: 366367.[Crossref] [Google Scholar]
  8. Lehtinen M, Ault KA, Lyytikainen E, Dillner J, Garland SM, Ferris DG, Koutsky LA, Sings HL, Lu S, Haupt RM, Paavonen J, , 2011. Chlamydia trachomatis infection and risk of cervical intraepithelial neoplasia. Sex Transm Infect 87: 372376.[Crossref] [Google Scholar]
  9. Santiago E, Camacho L, Junquera ML, Vázquez F, , 2006. Full HPV typing by a single restriction enzyme. J Clin Virol 37: 3846.[Crossref] [Google Scholar]
  10. Nauclear P, Chen HC, Persson K, You SL, Hsieh CY, Sun CA, Dillner J, Chen CJ, , 2007. Seroprevalence of human Papillomavirus and Chlamydia trachomatis and cervical cancer risk: nested case-control study. J Gen Virol 88: 814822.[Crossref] [Google Scholar]
  11. Calil LN, Igansi CN, Meurer L, Edelweiss MAI, Bozzetti MC, , 2011. Chlamydia trachomatis and Human papillomavirus coinfection: association with p16INK4a and Ki67 expression in biopsies of patients with pre-neoplastic and neoplastic lesions. Braz J Infect Dis 15: 126131.[Crossref] [Google Scholar]
  12. Gopalkrishma V, Aggarwal N, Malhotra VJ, Koranne RV, Mohan VP, Mittal ADBC, , 2000. Chlamydia trachomatis and Human papillomavirus infection in Indian women with sexually transmitted diseases and cervical precancerous and cancerous lesions. Clin Microbiol Infect 6: 8893.[Crossref] [Google Scholar]
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  • Received : 07 May 2012
  • Accepted : 03 Sep 2012
  • Published online : 05 Dec 2012

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