1921
Volume 88, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6–60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period in Niger. We compared the prevalence of wasting, low mid-upper arm circumference, stunting, and underweight in communities in the two treatment arms. We were unable to prove that there was a difference in the prevalence of wasting in the 12 communities that received one mass azithromycin distribution versus the 12 communities that received two mass azithromycin distributions (odds ratio = 0.75, 95% confidence interval = 0.46–1.23). Likewise, we were unable to detect a difference in the two treatment arms for low mid-upper arm circumference, stunting, and underweight. There may not be an association between antibiotic use and improved growth in humans, or this trial was not powerful enough to detect an association if it exists.

[open-access] This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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References

  1. Scrimshaw NS, Taylor CE, Gordon JE, , 1968. Interaction of Nutrition and Infection. World Health Organization Monograph Series 57. Geneva: World Health Organization.
  2. Caulfield LE, de Onis M, Blossner M, Black RE, , 2004. Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am J Clin Nutr 80: 193198.
  3. Katona P, Katona-Apte J, , 2008. The interaction between nutrition and infection. Clin Infect Dis 46: 15821588.[Crossref]
  4. Lode H, Borner K, Koeppe P, Schaberg T, , 1996. Azithromycin—review of key chemical, pharmacokinetic and microbiological features. J Antimicrob Chemother 37 (Suppl C): 18.[Crossref]
  5. Fry AM, Jha HC, Lietman TM, Chaudhary JS, Bhatta RC, Elliott J, Hyde T, Schuchat A, Gaynor B, Dowell SF, , 2002. Adverse and beneficial secondary effects of mass treatment with azithromycin to eliminate blindness due to trachoma in Nepal. Clin Infect Dis 35: 395402.[Crossref]
  6. Whitty CJ, Glasgow KW, Sadiq ST, Mabey DC, Bailey R, , 1999. Impact of community-based mass treatment for trachoma with oral azithromycin on general morbidity in Gambian children. Pediatr Infect Dis J 18: 955958.[Crossref]
  7. Sadiq ST, Glasgow KW, Drakeley CJ, Muller O, Greenwood BM, Mabey DC, Bailey RL, , 1995. Effects of azithromycin on malariometric indices in The Gambia. Lancet 346: 881882.[Crossref]
  8. Keenan JD, Ayele B, Gebre T, Zerihun M, Zhou Z, House JI, Gaynor BD, Porco TC, Emerson PM, Lietman TM, , 2011. Childhood mortality in a cohort treated with mass azithromycin for trachoma. Clin Infect Dis 52: 883888.[Crossref]
  9. Porco TC, Gebre T, Ayele B, House J, Keenan J, Zhou Z, Hong KC, Stoller N, Ray KJ, Emerson P, Gaynor BD, Lietman TM, , 2009. Effect of mass distribution of azithromycin for trachoma control on overall mortality in Ethiopian children: a randomized trial. JAMA 302: 962968.[Crossref]
  10. Stare D, Harding-Esch E, Munoz B, Bailey R, Mabey D, Holland M, Gaydos C, West S, , 2011. Design and baseline data of a randomized trial to evaluate coverage and frequency of mass treatment with azithromycin: the Partnership for Rapid Elimination of Trachoma (PRET) in Tanzania and The Gambia. Ophthalmic Epidemiol 18: 2029.[Crossref]
  11. Thylefors B, Dawson CR, Jones BR, West SK, Taylor HR, , 1987. A simple system for the assessment of trachoma and its complications. Bull World Health Organ 65: 477483.
  12. World Health Organization, 2010. Report of the Fourteenth Meeting of the WHO Alliance for Global Elimination of Blinding Trachoma. Geneva: World Health Organization.
  13. Team RDC, 2008. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.
  14. Amza A, Kadri B, Nassirou B, Stoller NE, Yu SN, Zhou Z, Chin S, West SK, Bailey RL, Mabey DCW, Keenan JD, Porco TC, Lietman TM, Gaynor BD, PRET Partnership; , 2012. Community risk factors for ocular chlamydia infection in Niger: pre-treatment results from a cluster-randomized trachoma trial. PLoS Negl Trop Dis 6: e1586.[Crossref]
  15. World Health Organization, 2008. WHO Child Growth Standards: Training Course on Child Growth Assessment. Geneva: World Health Organization.
  16. World Health Organization, 2010. WHO Anthro for Personal Computers, Version 3.2.2, 2011: Software for Assessing Growth and Development of the World's Children. Geneva: World Health Organization.
  17. Labrique AB, Christian P, Klemm RD, Rashid M, Shamim AA, Massie A, Schulze K, Hackman A, West KP, Jr, 2011. A cluster-randomized, placebo-controlled, maternal vitamin A or beta-carotene supplementation trial in Bangladesh: design and methods. Trials 12: 102.[Crossref]
  18. Group WMGRS, 2006. WHO Child Growth Standards: Length/Height-for-Age, Weight-for-Age, Weight-for-Length, Weight-for-Height and Body Mass Index-for-Age: Methods and Development. Geneva: World Health Organization.
  19. Gibson RS, , 2005. Principles of Nutritional Assessment. New York: Oxford University Press.
  20. Isanaka S, Nombela N, Djibo A, Poupard M, Van Beckhoven D, Gaboulaud V, Guerin PJ, Grais RF, , 2009. Effect of preventive supplementation with ready-to-use therapeutic food on the nutritional status, mortality, and morbidity of children aged 6 to 60 months in Niger: a cluster randomized trial. JAMA 301: 277285.[Crossref]
  21. May GS, DeMets DL, Friedman LM, Furberg C, Passamani E, , 1981. The randomized clinical trial: bias in analysis. Circulation 64: 669673.[Crossref]
  22. Sommer A, Zeger SL, , 1991. On estimating efficacy from clinical trials. Stat Med 10: 4552.[Crossref]
  23. Viola C, DeVincent SJ, , 2006. Overview of issues pertaining to the manufacture, distribution, and use of antimicrobials in animals and other information relevant to animal antimicrobial use data collection in the United States. Prev Vet Med 73: 111131.[Crossref]
  24. Oliver SP, Murinda SE, Jayarao BM, , 2011. Impact of antibiotic use in adult dairy cows on antimicrobial resistance of veterinary and human pathogens: a comprehensive review. Foodborne Pathog Dis 8: 337355.[Crossref]
  25. Visek WJ, , 1978. The mode of growth promotion by antibiotics. J Anim Sci 46: 14471469.[Crossref]
  26. Dibner JJ, Richards JD, , 2005. Antibiotic growth promoters in agriculture: history and mode of action. Poult Sci 84: 634643.[Crossref]
  27. Shryock TR, Page SW, Giguere S, Prescott JF, Baggot JD, Walker RD, Dowling PM, , 2007. Growth promotion uses of antimicrobial agents. In: , eds., Antimicrobial Therapy in Veterinary Medicine (4th ed, 389404). Ames, IA: Wiley-Blackwell Publishing.
  28. Taylor-Robinson DC, Maayan N, Soares-Weiser K, Donegan S, Garner P, , 2012. Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin and school performance. Cochrane Database Syst Rev 7: CD000371.
  29. Ayele B, Gebre T, House JI, Zhou Z, McCulloch CE, Porco TC, Gaynor BD, Emerson PM, Lietman TM, Keenan JD, , 2011. Adverse events after mass azithromycin treatments for trachoma in Ethiopia. Am J Trop Med Hyg 85: 291294.[Crossref]
  30. International Trachoma Initiative, 2011. International Trachoma Initiative: Frequently Asked Questions. Decatur, GA: International Trachoma Initiative.
  31. Skalet AH, Cevallos V, Ayele B, Gebre T, Zhou Z, Jorgensen JH, Zerihun M, Habte D, Assefa Y, Emerson PM, Gaynor BD, Porco TC, Lietman TM, Keenan JD, , 2010. Antibiotic selection pressure and macrolide resistance in nasopharyngeal Streptococcus pneumoniae: a cluster-randomized clinical trial. PLoS Med 7: e1000377.[Crossref]
  32. Haug S, Lakew T, Habtemariam G, Alemayehu W, Cevallos V, Zhou Z, House J, Ray K, Porco T, Rutar T, Keenan J, Lietman TM, Gaynor BD, , 2010. The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma. Clin Infect Dis 51: 571574.[Crossref]
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  • Received : 04 May 2012
  • Accepted : 04 Sep 2012

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