1921
Volume 87, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

A better understanding of the mechanism of anemia associated with infection might provide useful information on how treatment programs are implemented to minimize schistosomiasis-associated morbidity and maximize treatment impact. We used a cross-sectional study with serum samples from 206 Kenyan school children to determine the mechanisms in -associated anemia. Serum ferritin and soluble transferrin receptor levels were measured by using an enzyme-linked immunosorbent assay. Results suggest that -infected persons are more likely (odds ratio = 3.68, 95% confidence interval = 1.33–10.1) to have levels of serum ferritin (> 100 ng/mL) that are associated with anemia of inflammation (AI) than -uninfected children. Our results suggest that AI is the most common form of anemia in infections. In contrast, the mechanism of anemia in -uninfected children was iron deficiency. Moreover, the prevalence of AI in the study participants demonstrated a significant trend with infection intensity ( < 0.001). Our results are consistent with those observed in -associated anemia.

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  • Received : 18 Apr 2012
  • Accepted : 06 Aug 2012
  • Published online : 07 Nov 2012
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