1921
Volume 87, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The development of pre-erythrocytic vaccines is hindered by the lack of culture systems or experimental rodent models. To help bypass these roadblocks, we exploited the fact that naturally exposed Fy− individuals who lack the Duffy blood antigen (Fy) receptor are less likely to develop blood-stage infections; therefore, they preferentially develop immune responses to pre-erythrocytic–stage parasites, whereas Fy+ individuals experience both liver- and blood-stage infections and develop immune responses to both pre-erythrocytic and erythrocytic parasites. We screened 60 endemic sera from -exposed Fy+ or Fy− donors against a protein microarray containing 91 proteins with orthologs that were up-regulated in sporozoites. Antibodies against 10 antigens were identified in sera from -exposed individuals but not unexposed controls. This technology has promising implications in the discovery of potential vaccine candidates against malaria.

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2012-09-05
2017-09-26
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Supplementary Data

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  • Received : 05 Apr 2012
  • Accepted : 12 May 2012

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