Volume 87, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The impact of Chagas disease is no longer restricted to endemic areas. The aim of this study is to evaluate a 2-year period of a vertical transmission screening program of infection in a tertiary care hospital in Barcelona (Spain). Two enzyme-linked immunosorbent assays (recombinant and crude antigen) were performed in parallel to pregnant women at risk of infection. Discordant results were confirmed by a third diagnostic test. In the case of a positive result, the newborn was tested at birth and after 8 months of life. A total of 1,473 women met the inclusion criteria for the screening program with a resulting seroprevalence for of 3.5% (2.2–5.2% 95% confidence interval [95% CI]). One case of congenital infection was identified. Screening programs for vertically transmitted acute infection are beneficial in non-endemic areas for early detection and treatment of acute infection.


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  • Received : 07 Mar 2012
  • Accepted : 12 Aug 2012

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