1921
Volume 87, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The impact of Chagas disease is no longer restricted to endemic areas. The aim of this study is to evaluate a 2-year period of a vertical transmission screening program of infection in a tertiary care hospital in Barcelona (Spain). Two enzyme-linked immunosorbent assays (recombinant and crude antigen) were performed in parallel to pregnant women at risk of infection. Discordant results were confirmed by a third diagnostic test. In the case of a positive result, the newborn was tested at birth and after 8 months of life. A total of 1,473 women met the inclusion criteria for the screening program with a resulting seroprevalence for of 3.5% (2.2–5.2% 95% confidence interval [95% CI]). One case of congenital infection was identified. Screening programs for vertically transmitted acute infection are beneficial in non-endemic areas for early detection and treatment of acute infection.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2012.12-0152
2012-11-07
2017-09-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/87/5/832.html?itemId=/content/journals/10.4269/ajtmh.2012.12-0152&mimeType=html&fmt=ahah

References

  1. Schmunis GA, , 2007. Epidemiology of Chagas disease in non-endemic countries: the role of international migration. Mem Inst Oswaldo Cruz 102: 7585.[Crossref]
  2. Dias JC, Silveira AC, , 2005. Chagas disease in the Americas: current situation and perspectives. Rev Soc Bras Med Trop 38 (Suppl 2): 513.
  3. Prata A, , 2000. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1: 92100.[Crossref]
  4. 2003. Congenital infection with Trypanosoma cruzi: from mechanisms of transmission to strategies for diagnosis and control. Rev Soc Bras Med Trop 36: 767771.[Crossref]
  5. Muñoz J, Coll O, Juncosa T, Verges M, del Pino M, Fumado V, , 2009. Prevalence and vertical transmission of Trypanosoma cruzi infection among pregnant Latin American women attending 2 maternity clinics in Barcelona, Spain. Clin Infect Dis 48: 17361740.[Crossref]
  6. Jackson Y, Myers C, Diana A, Marti HP, Wolff H, Chappuis F, , 2009. Congenital transmission of Chagas disease in Latin American immigrants in Switzerland. Emerg Infect Dis 15: 601603.[Crossref]
  7. Riera C, Guarro A, Kassab HE, Jorba JM, Castro M, Angrill R, , 2006. Congenital transmission of Trypanosoma cruzi in Europe (Spain): a case report. Am J Trop Med Hyg 75: 10781081.
  8. Buekens P, Almendares O, Carlier Y, Dumonteli E, Eberhard M, Gamboa-Leon R, James M, Padilla N, Wesson D, Xiong X, , 2008. Mother to child transmission of Chagas's disease in North America: why don't we do more? Matern Child Health J 12: 283286.[Crossref]
  9. Torrico F, Alonso-Vega C, Suarez E, Rodriguez P, Torrico MC, Dramaix M, , 2004. Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in Bolivia. Am J Trop Med Hyg 70: 201209.
  10. IDESCAT, 2008. Foreign population by continents [Spanish]. Available at: www.idescat.cat. Accessed June 2011.
  11. Mora MC, Sanchez Negrette O, Marco D, Barrio A, Ciaccio M, Segura MA, Basombrío MA, , 2005. Early diagnosis of congenital Trypanosoma cruzi infection using PCR, hemoculture, and capillary concentration, as compared with delayed serology. J Parasitol 91: 14681473.[Crossref]
  12. Pirón M, Fisa R, Casamitjana N, , 2007. Development of a real-time PCR assay for Trypanosoma cruzi detection in blood samples. Acta Trop 103: 195200.[Crossref]
  13. Paricio-Talayero JM, Benlloch-Muncharaz MJ, Collar-del-Castillo JI, Rubio-Soriano A, Serrat-Perez C, Magraner-Egea J, , 2008. Epidemiological surveillance of vertically-transmitted Chagas disease at three maternity hospitals in the Valencian Community. Enferm Infecc Microbiol Clin 26: 609613.[Crossref]
  14. Ortí RM, Parada MC, , 2009. Prevalence of American Trypanosomiasis in pregnant women of a sanitary area. Valencia 2005–2007 [Spanish]. Rev Esp Salud Publica 83: 543555.
  15. Riera C, Verges M, Iniesta L, Fisa R, Gállego M, Tebar S, Portús M, , 2012. Identification of a Western blot pattern for the specific diagnosis of Trypanosoma cruzi infection in human sera. Am J Trop Med Hyg 86: 412416.[Crossref]
  16. Remesar MC, Gamba C, Colaianni IF, Puppo M, Sartor PA, Murphy EL, Neilands TB, Ridolfi MA, Leguizamón MS, Kuperman S, Del Pozo AE, , 2009. Estimation of sensitivity and specificity of several Trypanosoma cruzi antibody assays in blood donors in Argentina. Transfusion 49: 23522358.[Crossref]
  17. Russomando G, Tomassone MM, de Guillen I, Acosta N, Vera N, Almiron M, Candia N, Calcena MF, Figueredo A, , 1998. Treatment of congenital Chagas' disease diagnosed and followed up by the polymerase chain reaction. Am J Trop Med Hyg 59: 487491.
  18. Schijman A, Altcheh J, Burgos JM, Biancardi M, Bisio M, Levin MJ, Freilij H, , 2003. Aetiological treatment of congenital Chagas' disease diagnosed and monitored by the polymerase chain reaction. J Antimicrob Chemother 52: 441449.[Crossref]
  19. Chippaux JP, Salas AN, Santaya JA, , 2010. Antibody drop in newborns congenitally infected by Trypanosoma cruzi treated with benznidazole. Trop Med Int Health 15: 8793.
  20. Rassi A, Jr Rassi A, Marin-Neto JA, , 2010. Chagas disease. Lancet 375: 13881402.[Crossref]
  21. Schijman AG, Bisio M, Orellana L, Sued M, Duffy T, , 2011. International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patient. PLoS Negl Trop Dis 5: e931.[Crossref]
  22. Diez C, Manattini S, Zanuttini JC, Bottasso O, Marcipar I, , 2008. The value of molecular studies for the diagnosis of congenital Chagas disease in northeastern Argentina. Am J Trop Med Hyg 78: 624627.
  23. Mora MC, Sanchez-Negrette O, Marco D, , 2005. Early diagnosis of congenital Trypanosoma cruzi infection using PCR, hemoculture, and capillary concentration, as compared with delayed serology. J Parasitol 91: 14681473.[Crossref]
  24. Maldonado C, Albano S, Vettorazzi L, , 2004. Using polymerase chain reaction in early diagnosis of re-activated Trypanosoma cruzi infection after heart transplantation. J Heart Lung Transplant 23: 13451348.[Crossref]
  25. Bern C, Verastegui M, Gilman RH, Lafuente C, Galdos-Cardenas G, Calderon M, , 2009. Congenital Trypanosoma cruzi transmission in Santa Cruz, Bolivia. Clin Infect Dis 49: 16671674.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2012.12-0152
Loading
/content/journals/10.4269/ajtmh.2012.12-0152
Loading

Data & Media loading...

  • Received : 07 Mar 2012
  • Accepted : 12 Aug 2012

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error