1921
Volume 87, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The burden of dengue in Nicaragua has been steadily rising during the last three decades; however, there have been few efforts to quantify the burden (measured in disability-adjusted life years [DALYs]) and cost to society. Using primary data from the Nicaraguan Ministry of Health (MINSA), the total cost and burden of dengue were calculated from 1996 to 2010. Total costs included both direct costs from medical expenditures and prevention activities and indirect costs from lost productivity. The annual disease burden ranged from 99 to 805 DALYs per million, with a majority associated with classic dengue fever. The total cost was estimated to be US$13.5 million/year (range: US$5.1–27.6 million). This analysis can help improve allocation of dengue control resources in Nicaragua and the region. As one of the most comprehensive analyses of its type to date in Nicaragua and Latin America, this study can serve as a model to determine the burden and cost of dengue.

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References

  1. Massad E, Coutinho FA, , 2011. The cost of dengue control. Lancet 377: 16301631.[Crossref] [Google Scholar]
  2. Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, Hunsperger E, Kroeger A, Margolis HS, Martínez E, Nathan MB, Pelegrino JL, Simmons C, Yoksan S, Peeling RW, , 2010. Dengue: a continuing global threat. Nat Rev Microbiol 8: S7S16.[Crossref] [Google Scholar]
  3. Halstead SB, , 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239: 476481.[Crossref] [Google Scholar]
  4. Halstead SB, , 2007. Dengue. Lancet 370: 16441652.[Crossref] [Google Scholar]
  5. Torres JR, Castro J, , 2007. The health and economic impact of dengue in Latin America. Cad Saude Publica 23 (Suppl 1): S23S31. [Google Scholar]
  6. WHO, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: World Health Organization. [Google Scholar]
  7. Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Periago MR, , 2008. The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl Trop Dis 2: e300.[Crossref] [Google Scholar]
  8. Harris E, Videa E, Perez L, Sandoval E, Tellez Y, Perez ML, Cuadra R, Rocha J, Idiaquez W, Alonso RE, Delgado MA, Campo LA, Acevedo F, Gonzalez A, Amador JJ, Balmaseda A, , 2000. Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua. Am J Trop Med Hyg 63: 511. [Google Scholar]
  9. Standish K, Kuan G, Aviles W, Balmaseda A, Harris E, , 2010. High dengue case capture rate in four years of a cohort study in Nicaragua compared to national surveillance data. PLoS Negl Trop Dis 4: e633.[Crossref] [Google Scholar]
  10. Ferrando J, , 1995. Estimate of the Costs of the Dengue Epidemic in 1994 in Nicaragua. Washington, DC: Pan American Health Organization. [Google Scholar]
  11. Shepard DS, Coudeville L, Halasa YA, Zambrano B, Dayan GH, , 2011. Economic impact of dengue illness in the Americas. Am J Trop Med Hyg 84: 200207.[Crossref] [Google Scholar]
  12. Armien B, Suaya JA, Quiroz E, Sah BK, Bayard V, Marchena L, Campos C, Shepard DS, , 2008. Clinical characteristics and national economic cost of the 2005 dengue epidemic in Panama. Am J Trop Med Hyg 79: 364371. [Google Scholar]
  13. Shepard DS, , 2009. Aggregate economic cost of dengue in Puerto Rico. Proceedings of the 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene. Washington, DC, November 18–22. [Google Scholar]
  14. Kongsin S, Jiamton S, Suaya JA, Vasanawathana S, Sirisuvan P, Shepard DS, , 2010. Cost of Dengue in Thailand. Bangkok, Thailand: Mahidol University School of Public Health. [Google Scholar]
  15. Tapia-Conyer R, Méndez-Galván JF, Gallardo-Rincón H, , 2009. The growing burden of dengue in Latin America. J Clin Virol 46: S3S6.[Crossref] [Google Scholar]
  16. Murray CJ, , 1994. Quantifying the burden of disease: the technical basis for disability-adjusted life years. Bull World Health Organ 72: 429445. [Google Scholar]
  17. Murray CJ, Lopez AD, , 1994. Quantifying disability: data, methods and results. Bull World Health Organ 72: 481494. [Google Scholar]
  18. PAHO, 2012. Dengue Regional Information: Number of Cases. Available at: http://new.paho.org/hq/index.php?option=com_content&task=view&id=264&Itemid=363&. Accessed January 12, 2012. [Google Scholar]
  19. Muiser J, Sáenz M, Bermúdez J, , 2011. Sistema de salud de Nicaragua. Salud Publica Mex 53: S233S242. [Google Scholar]
  20. PAHO, 2000. Norms and Standards in Epidemiology: Case Definitions for Dengue Fever and Leptospirosis. Epidemiol Bull 21. Available at: http://www.paho.org/english/sha/eb_v21n2-cov.htm. Accessed January 12, 2012. [Google Scholar]
  21. Meltzer MI, Rigau-Perez JG, Clark GG, Reiter P, Gubler DJ, , 1998. Using disability-adjusted life years to assess the economic impact of dengue in Puerto Rico: 1984–1994. Am J Trop Med Hyg 59: 265271. [Google Scholar]
  22. Salvatierra-González R, , 2003. Costo de la infección nosocomial en nueve países de América Latina. Washington DC: OPS.
  23. Luz PM, Grinsztejn B, Galvani AP, , 2009. Disability adjusted life years lost to dengue in Brazil. Trop Med Int Health 14: 237246.[Crossref] [Google Scholar]
  24. Suaya J, Shepard D, Beatty M, , 2007. Dengue Burden of Disease and Cost of Illness. Geneva: World Health Organization on behalf of the Special Programme for Research and Training in Tropical Diseases, 3549. [Google Scholar]
  25. Gubler DJ, , 2002. How effectively is epidemiological surveillance used for dengue programme planning and epidemic response? Dengue Bull 26: 96106. [Google Scholar]
  26. Murray CJ, López AD, Bank W, , 1996. The Global Burden of Disease: a Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and projected to 2020. Published by the Harvard School of Public Health on behalf of the World Health Organization and the World Bank. [Google Scholar]
  27. Clark DV, Mammen MP, Nisalak A, Puthimethee V, Endy TP, , 2005. Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels. Am J Trop Med Hyg 72: 786791. [Google Scholar]
  28. Suaya JA, Shepard DS, Siqueira JB, Martelli CT, Lum LC, Tan LH, Kongsin S, Jiamton S, Garrido F, Montoya R, Armien B, Huy R, Castillo L, Caram M, Sah BK, Sughayyar R, Tyo KR, Halstead SB, , 2009. Cost of dengue cases in eight countries in the Americas and Asia: a prospective study. Am J Trop Med Hyg 80: 846855. [Google Scholar]
  29. Balmaseda A, Hammond SN, Tellez Y, Imhoff L, Rodriguez Y, Saborio SI, Mercado JC, Perez L, Videa E, Almanza E, Kuan G, Reyes M, Saenz L, Amador JJ, Harris E, , 2006. High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Trop Med Int Health 11: 935942.[Crossref] [Google Scholar]
  30. U.S. State Department, 2011. 2010 Human Rights Report: Nicaragua. Available at: http://www.state.gov/g/drl/rls/hrrpt/2010/wha/154513.htm. Accessed January 12, 2012. [Google Scholar]
  31. Anderson KB, Chunsuttiwat S, Nisalak A, Mammen MP, Libraty DH, Rothman AL, Green S, Vaughn DW, Ennis FA, Endy TP, , 2007. Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study. Lancet 369: 14521459.[Crossref] [Google Scholar]
  32. Beaute J, Vong S, , 2010. Cost and disease burden of dengue in Cambodia. BMC Public Health 10: 521.[Crossref] [Google Scholar]
  33. Garg P, Nagpal J, Khairnar P, Seneviratne SL, , 2008. Economic burden of dengue infections in India. Trans R Soc Trop Med Hyg 102: 570577.[Crossref] [Google Scholar]
  34. Huy R, Wichmann O, Beatty M, Ngan C, Duong S, Margolis HS, Vong S, , 2009. Cost of dengue and other febrile illnesses to households in rural Cambodia: a prospective community-based case-control study. BMC Public Health 9: 155.[Crossref] [Google Scholar]
  35. Mathers C, Fat DM, Boerma JT, , 2008. The Global Burden of Disease: 2004 Update. Geneva: World Health Organization. [Google Scholar]
  36. Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB, , 2002. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis 6: 118124.[Crossref] [Google Scholar]
  37. Malavige GN, Fernando S, Fernando DJ, Seneviratne SL, , 2004. Dengue viral infections. Postgrad Med J 80: 588601.[Crossref] [Google Scholar]
  38. Pinheiro FP, Corber SJ, , 1997. Global situation of dengue and dengue hemorrhagic fever, and its emergence in the Americas. World Health Stat Q 50: 161169. [Google Scholar]
  39. Seyler T, Hutin Y, Ramanchandran V, Ramakrishnan R, Manickam P, Murhekar M, , 2010. Estimating the burden of disease and the economic cost attributable to chikungunya, Andhra Pradesh, India, 2005–2006. Trans R Soc Trop Med Hyg 104: 133138.[Crossref] [Google Scholar]
  40. Valdes LG, Mizhrahi JV, Guzman MG, , 2002. Economic impact of dengue 2 epidemic in Santiago de Cuba, 1997. Rev Cubana Med Trop 54: 220227. [Google Scholar]
  41. Von Allmen SD, Lopez-Correa RH, Woodall JP, Morens DM, Chiriboga J, Casta-Velez A, , 1979. Epidemic dengue fever in Puerto Rico, 1977: a cost analysis. Am J Trop Med Hyg 28: 10401044. [Google Scholar]
  42. Tarricone R, , 2006. Cost-of-illness analysis: what room in health economics? Health Policy 77: 5163.[Crossref] [Google Scholar]
  43. Byford S, Torgerson DJ, Raftery J, , 2000. Cost of illness studies. BMJ 320: 1335.[Crossref] [Google Scholar]
  44. Shiell A, Gerard K, Donaldson C, , 1987. Cost of illness studies: an aid to decision-making? Health Policy 8: 317323.[Crossref] [Google Scholar]
  45. Hodgson TA, , 1989. Cost of illness studies: no aid to decision making? Comments on the second opinion by Shiell et al. (Health Policy 8(1987)317–323). Health Policy 11: 5760.[Crossref] [Google Scholar]
  46. Beatty ME, Beutels P, Meltzer MI, Shepard DS, Hombach J, Hutubessy R, Dessis D, Coudeville L, Dervaux B, Wichmann O, Margolis HS, Kuritsky JN, , 2011. Health economics of dengue: a systematic literature review and expert panel's assessment. Am J Trop Med Hyg 84: 473488.[Crossref] [Google Scholar]
  47. Lee BY, Connor DL, Kitchen SB, Bacon KM, Shah M, Brown ST, Bailey RR, Laosiritaworn Y, Burke DS, Cummings DA, , 2011. Economic value of dengue vaccine in Thailand. Am J Trop Med Hyg 84: 764772.[Crossref] [Google Scholar]
  48. Shepard DS, Suaya JA, Halstead SB, Nathan MB, Gubler DJ, Mahoney RT, Wang DNC, Meltzer MI, , 2004. Cost-effectiveness of a pediatric dengue vaccine. Vaccine 22: 12751280.[Crossref] [Google Scholar]
  49. Shepard DS, Suaya JA, Preedy VR, Watson RR, , 2010. Cost-effectiveness of a dengue vaccine in Southeast Asia and Panama: preliminary estimates. , eds. Handbook of Disease Burdens and Quality of Life Measures. New York: Springer, Chapter 73: 12811296.[Crossref] [Google Scholar]
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  • Received : 06 Mar 2012
  • Accepted : 12 Jul 2012
  • Published online : 03 Oct 2012

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