1921
Volume 87, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Rapid diagnostics tests (RDTs) detect malaria specific antigen(s) in the circulation, even when parasites are sequestered in the placenta and not visible by microscopy. However, research on their diagnostic accuracy during pregnancy is limited. Pregnant women (n = 418) were screened for malaria during routine antenatal care by using two RDTs that detect histidine-rich protein 2 (HRP2) or lactate dehydrogenase, and enzyme-linked immunosorbent assays with antibodies that detect dihydrofolate reductase–thymidylate synthase or heme-detoxification protein, and compared with real-time polymerase chain reaction (RT-PCR) and microscopy for evaluation of their diagnostic accuracy. Prevalence of malaria infection was high (53% by PCR). The RT-PCR and the HRP2 RDT detected most cases of malaria during pregnancy, whereas microscopy, the lactate dehydrogenase RDT, and enzyme-linked immunosorbent assays for dihydrofolate reductase–thymidylate synthase and heme-detoxification protein antibodies did not detect several low-density infections. Therefore, the HRP2 RDT could be a useful tool in high-transmission areas for diagnosis of malaria in asymptomatic pregnant women.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2012.12-0125
2012-08-01
2017-11-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/87/2/251.html?itemId=/content/journals/10.4269/ajtmh.2012.12-0125&mimeType=html&fmt=ahah

References

  1. Hartman TK, Rogerson SJ, Fischer PR, , 2010. The impact of maternal malaria on newborns. Ann Trop Paediatr 30: 271282.[Crossref]
  2. Nosten F, McGready R, Simpson JA, Thwai KL, Balkan S, Cho T, Hkirijaroen L, Looareesuwan S, White NJ, , 1999. Effects of Plasmodium vivax malaria in pregnancy. Lancet 354: 546549.[Crossref]
  3. Rogerson SJ, Hviid L, Duffy PE, Leke RF, Taylor DW, , 2007. Malaria in pregnancy: pathogenesis and immunity. Lancet Infect Dis 7: 105117.[Crossref]
  4. Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, Newman RD, , 2007. Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis 7: 93104.[Crossref]
  5. Nosten F, Rogerson SJ, Beeson JG, McGready R, Mutabingwa TK, Brabin B, , 2004. Malaria in pregnancy and the endemicity spectrum: what can we learn? Trends Parasitol 20: 425432.[Crossref]
  6. Kattenberg JH, Ochodo EA, Boer KR, Schallig HD, Mens PF, Leeflang MM, , 2011. Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women. Malar J 10: 321.[Crossref]
  7. Miller LH, Baruch DI, Marsh K, Doumbo OK, , 2002. The pathogenic basis of malaria. Nature 415: 6734679.[Crossref]
  8. Uneke CJ, , 2008. Diagnosis of Plasmodium falciparum malaria in pregnancy in sub-Saharan Africa: the challenges and public health implications. Parasitol Res 102: 333342.[Crossref]
  9. WHO, 2008. Malaria Rapid Diagnostic Test Performance—Results of WHO Product Testing of Malaria RDTs: Round 1. Geneva: World Health Organization.
  10. WHO, 2009. Malaria Rapid Diagnostic Test Performance—Results of WHO Product Testing of Malaria RDTs: Round 2. Geneva: World Health Organization.
  11. Bell D, Wongsrichanalai C, Barnwell JW, , 2006. Ensuring quality and access for malaria diagnosis: how can it be achieved? Nat Rev Microbiol 4: 682695.[Crossref]
  12. Baker J, McCarthy J, Gatton M, Kyle DE, Belizario V, Luchavez J, Bell D, Cheng Q, , 2005. Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PFHRP2-based diagnostic tests. J Infect Dis 192: 870877.[Crossref]
  13. Perkins MD, Bell DR, , 2008. Working without a blindfold: the critical role of diagnostics in malaria control. Malar J 7 (Suppl 1): S5.[Crossref]
  14. Kattenberg JH, Versteeg I, Migchelsen SJ, González IJ, Perkins MD, Mens PF, Schallig HD, , 2012. New developments in malaria diagnostics: monoclonal antibodies against Plasmodium dihydrofolate reductase–thymidylate synthase, heme detoxification protein and glutamate rich protein. MAbs 4: 120126.[Crossref]
  15. World Health Organization, 2010. Basic Malaria Microscopy. Part I: Learner's Guide. 2nd edition. Geneva: World Health Organization.
  16. Kattenberg JH, Tahita CM, Versteeg I, Tinto H, Traoré/Coulibaly M, Schallig HD, Mens PF, , 2012. Antigen persistence of rapid diagnostic tests in pregnant women in Nanoro, Burkina Faso and the implications for the diagnosis of malaria in pregnancy. Trop Med Int Health 17: 550557.[Crossref]
  17. Greenwood BM, Armstrong JR, , 1991. Comparison of two simple methods for determining malaria parasite density. Trans R Soc Trop Med Hyg 85: 186188.[Crossref]
  18. Boom R, Sol CJ, Salimans MM, Jansen CL, Wertheim-van Dillen PM, van der Noordaa J, , 1990. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 28: 495503.
  19. Hermsen CC, Telgt DS, Linders EH, van de Locht LA, Eling WM, Mensink EJ, Sauerwein RW, , 2001. Detection of Plasmodium falciparum malaria parasites in vivo by real-time quantitative PCR. Mol Biochem Parasitol 118: 247251.[Crossref]
  20. Wang CW, Hermsen CC, Sauerwein RW, Arnot DE, Theander TG, Lavstsen T, , 2009. The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer. Parasitol Int 58: 478480.[Crossref]
  21. Banoo S, Bell D, Bossuyt P, Herring A, Mabey D, Poole F, Smith PG, Sriram N, Wongsrichanalai C, Linke R, O'Brien R, Perkins M, Cunningham J, Matsoso P, Nathanson CM, Olliaro P, Peeling RW, Ramsay A, , 2006. Evaluation of diagnostic tests for infectious diseases: general principles. Nat Rev Microbiol 4 (Suppl): S20S32.[Crossref]
  22. Arango E, Maestre A, Carmona-Fonseca J, , 2010. Effecto de la infección submicroscópica o poloclonal de Plasmodium falciparum sobre la madre y el producto de la gestación. Revisión sistemàtica. Rev Bras Epidemiol 13: 373386.[Crossref]
  23. McGready R, Davison BB, Stepniewska K, Cho T, Shee H, Brockman A, Udomsangpetch R, Looareesuwan S, White NJ, Meshnick SR, Nosten F, , 2004. The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission. Am J Trop Med Hyg 70: 398407.
  24. Tagbor H, Bruce J, Agbo M, Greenwood B, Chandramohan D, , 2010. Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: a randomised controlled non-inferiority trial. PLoS ONE 5: e14425.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2012.12-0125
Loading
/content/journals/10.4269/ajtmh.2012.12-0125
Loading

Data & Media loading...

  • Received : 23 Feb 2012
  • Accepted : 07 May 2012

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error