1921
Volume 87, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Emerging resistance to chloroquine (CQ) poses a major challenge for malaria control, and nucleotide substitutions and copy number variation in the multidrug resistance 1 () locus, which encodes a digestive vacuole membrane transporter, may modulate this phenotype. We describe patterns of genetic variation in alleles from Acre and Amazonas in northwestern Brazil, and compare then with those reported in other malaria-endemic regions. The mutation Y976F, which is associated with CQ resistance in Southeast Asia and Oceania, remains rare in northwestern Brazil (1.8%) and its prevalence mirrors that of CQ resistance worldwide. Gene amplification of , which is associated with mefloquine resistance but increased susceptibility to CQ, remains relatively rare in northwestern Brazil (0.9%) and globally (< 4%), but became common (> 10%) in Tak Province, Thailand, possibly because of drug-mediated selection. The global database we have assembled provides a baseline for further studies of genetic variation in and drug resistance in malaria.

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2012-11-07
2017-09-20
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Supplementary Data

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  • Received : 10 Feb 2012
  • Accepted : 28 Jul 2012

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