1921
Volume 87, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Knowledge of the prevalence and risk factors associated with maternal infection is the first step to develop a surveillance system for congenital transmission of Chagas disease. We conducted a cross-sectional study in Casanare, a disease-endemic area in Colombia. A total of 982 patients were enrolled in the study. A global prevalence of infection of 4.0% (95% confidence interval [CI] = 2.8–5.3%) was found. Multivariate analysis showed that the most important risk-associated factors were age > 29 years (adjusted odds ratio [aOR] = 3.4, 95% CI = 0.9–12.4), rural residency (aOR = 2.2, 95% CI = 1.0–4.6), low education level (aOR = 10.2, 95% CI = 1.6–82.7), and previous knowledge of the vector (aOR = 2.2, 95% CI = 1.0–4.9). Relatives and siblings of infected mothers showed a prevalence of 9.3%. These findings may help physicians to investigate congenital cases, screen Chagas disease in siblings and relatives, and provide early treatment to prevent the chronic complications of Chagas disease.

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2012-11-07
2017-11-19
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References

  1. Pan American Health Organization, 2006. Quantitative Estimation of Chagas Disease in the Americas. Washington, DC: Pan American Health Organization, OPS/HDM/CD/425-06:6.
  2. Yadon ZE, Schmunis GA, , 2009. Congenital Chagas disease: estimating the potential risk in the United States. Am J Trop Med Hyg 81: 927933.[Crossref]
  3. Oliveira I, Torrico F, Muñoz J, Gascon J, , 2010. Congenital transmission of Chagas disease: a clinical approach. Expert Rev Anti Infect Ther 8: 945956.[Crossref]
  4. Buekens P, Almendares O, Carlier Y, Dumonteil E, Eberhard M, Gamboa-Leon R, James M, Padilla N, Wesson D, Xiong X, , 2008. Mother-to-child transmission of Chagas' disease in North America: why don't we do more? Matern Child Health J 12: 283286.[Crossref]
  5. Jackson Y, Myers C, Diana A, Marti HP, Wolff H, Chappuis F, Loutan L, Gervaix A, , 2009. Congenital transmission of Chagas disease in Latin American immigrants in Switzerland. Emerg Infect Dis 15: 601603.[Crossref]
  6. Verani JR, Montgomery SP, Schulkin J, Anderson B, Jones JL, , 2010. Survey of obstetrician-gynecologists in the United States about Chagas disease. Am J Trop Med Hyg 83: 891895.[Crossref]
  7. Torrico F, Alonso-Vega C, Suarez E, Rodríguez P, Torrico MC, Dramaix M, Truyens C, Carlier Y, , 2005. Endemic level of congenital Trypanosoma cruzi infection in the areas of maternal residence and the development of congenital Chagas disease in Bolivia. Rev Soc Bras Med Trop 38 (Suppl 2): 1720.
  8. Mendoza Ticona CA, Córdova Benzaquen E, Ancca Juárez J, Saldaña Díaz J, Torres Choque A, Velásquez Talavera R, de los Ríos Alvarez J, Saldaña Díaz J, Vega Chirinos S, Sánchez Pérez R, , 2005. The prevalence of Chagas' disease in puerperal women and congenital transmission in an endemic area of Peru. Rev Panam Salud Publica 17: 147153.[Crossref]
  9. Araujo A, Castagno V, Gallina T, Berne M, , 2009. Prevalência da doença de Chagas em gestantes da região sul do Rio Grande do Sul. Rev Soc Bras Med Trop 42: 732733.[Crossref]
  10. Luquetti AO, Dias JC, Prata A, , 2005. Diagnóstico y tratamiento de la infección congénita por Trypanosoma cruzi en Brasil. Rev Soc Bras Med Trop 38 (Suppl 2): 2628.
  11. Moya P, Basso B, Moretti E, , 2005. Enfermedad de Chagas congénita en Córdoba, Argentina: aspectos epidemiológicos, clínicos, diagnósticos y terapéuticos. Experiencia de 30 años de seguimiento. Rev Soc Bras Med Trop 38 (Suppl 2): 3340.
  12. Sosa-Estani S, , 2005. Congenital transmission of Trypanosoma cruzi infection in Argentina. Rev Soc Bras Med Trop 38 (Suppl 2): 2932.
  13. Manrique-Abril FG, Herrera G, Ospina JM, Pavia P, Puerta CJ, Montilla M, Florez AC, Nicholls RS, , 2009. Prevalencia de enfermedad de Chagas en maternas e incidencia transplacentario en Boyacá. Biomedica 29 (Suppl 1): 315316.
  14. Guhl F, Aguilera G, Pinto N, Vergara D, , 2007. Updated geographical distribution and ecoepidemiology of the triatomine fauna (Reduviidae: Triatominae) in Colombia. Biomedica 27 (Suppl 1): 143162.[Crossref]
  15. Departamento Administrativo Nacional de Estadística (DANE), 2010. Estadísticas Vitales/Nacimientos. Available at: http://www.dane.gov.co/index.php?option=com_content&view=article&id=786&Itemid=119. Accessed January 15, 2010.
  16. Lopez MC, Duque S, Orozco LC, Camargo D, Gualdron LE, Caceres E, Ronderos M, Rey M, Corredor A, , 1999. Inmunodiagnóstico de la infección chagásica por ELISA. Biomedica 19: 159163.[Crossref]
  17. Camargo ME, , 1966. Fluorescent antibodytest for the serodiagnosis of American trypanosomiasis. Technical modification employing preserved culture forms of Trypanosoma cruzi in a slide test. Rev Inst Med Trop Sao Paulo 8: 227234.
  18. Orozco LC, Camargo D, Lopez MC, Duque S, Gualdron LE, Cáceres E, Ronderos M, Rey M, Corredor A, , 1999. Inmunodiagnóstico de la infección en humanos por Trypanosoma cruzi mediante ELISA utilizando sangre recolectada en papel de filtro. Biomedica 19: 164168.[Crossref]
  19. Sistema de Identificación de Potenciales Beneficiarios de Programas Sociales (SISBEN), 2010. Available at: http://www.sisben.gov.co/Inicio/ConsultadePuntaje.aspx. Accessed June 2, 2011.
  20. de Salud M, Dirección de Desarrollo Científico y Tecnológico, , 1993. Normas Científicas, Técnicas y Administrativas para la Investigación en Salud. Resolución No. 008430 de 1993. Bogotá, Colombia: Imprenta Nacional; 1993.
  21. World Medical Association, 2000. Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects. Last revision. 52nd WMA General Assembly. Edinburgh, Scotland: World Medical Association.
  22. World Health Assembly, 2010. Chagas Disease: Control and Elimination. In: Sixty-third World Health Assembly Resolutions, Geneva, May 17–21, 2010. Resolutions and Decisions, Annexes (WHA63/2010/REC/1), Resolution WHA 63. 0: 39-42. Available at: http://apps.who.int/gb/ebwha/pdf_files/WHA63-REC1/WHA63_REC1-en.pdf. Accessed November 23, 2011.
  23. Hidron AI, Gilman RH, Justiniano J, Blackstock AJ, Lafuente C, Selum W, Calderon M, Verastegui M, Ferrufino L, Valencia E, Tornheim JA, O'Neal S, Comer R, Galdos-Cardenas G, Bern C, Chagas Disease Working Group in Peru and Bolivia, , 2010. Chagas cardiomyopathy in the context of the chronic disease transition. PLoS Negl Trop Dis 4: e688.[Crossref]
  24. Campbell-Lendrum DH, Angulo VM, Esteban L, Tarazona Z, Parra GJ, Restrepo M, Restrepo BN, Guhl F, Pinto N, Aguilera G, Wilkinson P, Davies CR, , 2007. House-level risk factors for triatomine infestation in Colombia. Int J Epidemiol 36: 866872.[Crossref]
  25. Comisión de Regulación en Salud, Acuerdo Número 08 de Diciembre de 2009. Anexo 1. Por el Cual se Actualizan los Planes Obligatorios de Salud. Available at: http://www.alcaldiabogota.gov.co/sisjur/normas/Norma1.jsp?i=38488. Accessed August 16, 2011.
  26. Viotti R, Vigliano CA, Alvarez MG, Lococo BE, Petti MA, Bertocchi GL, Armenti AH, , 2009. The impact of socioeconomic conditions on chronic Chagas disease progression. Rev Esp Cardiol 62: 12241232.[Crossref]
  27. Sosa-Estani S, Cura E, Velazquez E, Yampotis C, Segura EL, , 2009. Etiological treatment of young women infected with Trypanosoma cruzi, and prevention of congenital transmission. Rev Soc Bras Med Trop 42: 484487.[Crossref]
  28. Carlier Y, Torrico F, Sosa-Estani S, Russomando G, Luquetti A, Freilij H, Albajar Vinas P, , 2011. Congenital chagas disease: recommendations for diagnosis, treatment and control of newborns, siblings and pregnant women. PLoS Negl Trop Dis 5: e1250.[Crossref]
  29. Russomando G, Almirón M, Candia N, Franco L, Sánchez Z, de Guillen I, , 2005. Implementación y evaluación de un sistema localmente sustentable de diagnostico prenatal que permite detectar casos de transmisión congénita de la enfermedad de Chagas en zonas endémicas del Paraguay. Rev Soc Bras Med Trop 38 (Suppl 2): 4954.
  30. Romero M, Postigo J, Schneider D, Chippaux JP, Santalla JA, Brutus L, , 2011. Door-to-door screening as a strategy for the detection of congenital Chagas disease in rural Bolivia. Trop Med Int Health 16: 562569.[Crossref]
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  • Received : 06 Feb 2012
  • Accepted : 09 Jun 2012

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