1921
Volume 87, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The pathogenesis of plasma leakage during dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is largely unknown. Angiopoietins are key regulators of vascular integrity: Angiopoietin-1 is stored in platelets and maintains vascular integrity, and endothelium-derived angiopoietin-2 promotes vascular leakage. We determined angiopoietin-1 and angiopoietin-2 levels in a cohort of children in Indonesia with DHF/DSS and related them to plasma leakage markers. Patients with DHF/DSS had reduced angiopoietin-1 and increased angiopoietin-2 plasma levels on the day of admission when compared with levels at discharge and in healthy controls. There was an inverse correlation between angiopoietin-1 and markers of plasma leakage and a positive correlation between angiopoietin-2 and markers of plasma leakage. Angiopoietin-1 levels followed the same trend as the soluble platelet activation marker P-selectin and correlated with platelet counts. Dengue-associated thrombocytopenia and endothelial activation are associated with an imbalance in angiopoietin-2: angiopoietin-1 plasma levels. This imbalance may contribute to the transient plasma leakage in DHF/DSS.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2012.12-0020
2012-11-07
2017-11-23
Loading full text...

Full text loading...

/deliver/fulltext/14761645/87/5/943.html?itemId=/content/journals/10.4269/ajtmh.2012.12-0020&mimeType=html&fmt=ahah

References

  1. Halstead SB, , 2007. Dengue. Lancet 370: 16441652.[Crossref]
  2. Noisakran S, Chokephaibulkit K, Songprakhon P, Onlamoon N, Hsiao HM, Villinger F, Ansari A, Perng GC, , 2009. A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. Ann N Y Acad Sci 1171 (Suppl 1): E24E35.[Crossref]
  3. Chaturvedi UC, Agarwal R, Elbishbishi EA, Mustafa AS, , 2000. Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis. FEMS Immunol Med Microbiol 28: 183188.[Crossref]
  4. Becquart P, Wauquier N, Nkoghe D, Ndjoyi-Mbiguino A, Padilla C, Souris M, Leroy EM, , 2010. Acute dengue virus 2 infection in Gabonese patients is associated with an early innate immune response, including strong interferon alpha production. BMC Infect Dis 10: 356.[Crossref]
  5. Sathupan P, Khongphattanayothin A, Srisai J, Srikaew K, Poovorawan Y, , 2007. The role of vascular endothelial growth factor leading to vascular leakage in children with dengue virus infection. Ann Trop Paediatr 27: 179184.[Crossref]
  6. Seet RC, Chow AW, Quek AM, Chan YH, Lim EC, , 2009. Relationship between circulating vascular endothelial growth factor and its soluble receptors in adults with dengue virus infection: a case-control study. Int J Infect Dis 13: e248e253.[Crossref]
  7. Srikiatkhachorn A, Ajariyakhajorn C, Endy TP, Kalayanarooj S, Libraty DH, Green S, Ennis FA, Rothman AL, , 2007. Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic fever. J Virol 81: 15921600.[Crossref]
  8. Tseng CS, Lo HW, Teng HC, Lo WC, Ker CG, , 2005. Elevated levels of plasma VEGF in patients with dengue hemorrhagic fever. FEMS Immunol Med Microbiol 43: 99102.[Crossref]
  9. van Meurs M, Kumpers P, Ligtenberg JJ, Meertens JH, Molema G, Zijlstra JG, , 2009. Bench-to-bedside review: angiopoietin signalling in critical illness - a future target? Crit Care 13: 207.[Crossref]
  10. Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, Glazer N, Holash J, McDonald DM, Yancopoulos GD, , 2000. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6: 460463.[Crossref]
  11. Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG, , 2006. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 12: 235239.[Crossref]
  12. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG, , 2004. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103: 41504156.[Crossref]
  13. Li JJ, Huang YQ, Basch R, Karpatkin S, , 2001. Thrombin induces the release of angiopoietin-1 from platelets. Thromb Haemost 85: 204206.
  14. Nachman RL, Rafii S, , 2008. Platelets, petechiae, and preservation of the vascular wall. N Engl J Med 359: 12611270.[Crossref]
  15. Sosothikul D, Seksarn P, Pongsewalak S, Thisyakorn U, Lusher J, , 2007. Activation of endothelial cells, coagulation and fibrinolysis in children with dengue virus infection. Thromb Haemost 97: 627634.
  16. Michels M, Djamiatun K, Faradz SM, Koenders MM, de Mast Q, van der Ven AJ, , 2011. High plasma mid-regional pro-adrenomedullin levels in children with severe dengue virus infections. J Clin Virol 50: 812.[Crossref]
  17. Anonymous, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition. Geneva: World Health Organization. Available at: http://www.who.int/csr/resources/publications/dengue/itoviii.pdf.
  18. Panzer S, Rosales S, Gisslinger H, Jungbauer L, Kaider A, Knöbl P, Sillaber C, Pabinger I, , 2008. Plasma levels of P-selectin are determined by platelet turn-over and the P-selectin Thr715Pro polymorphism. Thromb Res 121: 573579.[Crossref]
  19. Hormbrey E, Gillespie P, Turner K, Han C, Roberts A, McGrouther D, Harris AL, , 2002. A critical review of vascular endothelial growth factor (VEGF) analysis in peripheral blood: is the current literature meaningful? Clin Exp Metastasis 19: 651663.[Crossref]
  20. Djamiatun K, van der Ven AJ, de Groot PG, Faradz SM, Hapsari D, Dolmans WM, Sebastian S, Fijnheer R, de Mast Q, , 2012. Severe dengue is aasociated with consumption of von Willebrand factor and its cleaving enzyme ADAMTS-13. PLoS Negl Trop Dis 6: e1628.[Crossref]
  21. Rondaij MG, Bierings R, Kragt A, van Mourik JA, Voorberg J, , 2006. Dynamics and plasticity of Weibel-Palade bodies in endothelial cells. Arterioscler Thromb Vasc Biol 26: 10021007.[Crossref]
  22. Steinberg BE, Goldenberg NM, Lee WL, , 2012. Do viral infections mimic bacterial sepsis? The role of microvascular permeability: a review of mechanisms and methods. Antiviral Res 93: 215.[Crossref]
  23. Dalrymple N, Mackow ER, , 2011. Productive dengue virus infection of human endothelial cells is directed by heparan sulfate-containing proteoglycan receptors. J Virol 85: 94789485.[Crossref]
  24. Brown MG, Hermann LL, Issekutz AC, Marshall JS, Rowter D, Al-Afif A, Anderson R, , 2011. Dengue virus infection of mast cells triggers endothelial cell activation. J Virol 85: 11451150.[Crossref]
  25. Furuta T, Murao LA, Lan NT, Huy NT, Huong VT, Thuy TT, Tham VD, Nga CT, Ha TT, Ohmoto Y, Kikuchi M, Morita K, Yasunami M, Hirayama K, Watanabe N, , 2012. Association of mast cell-derived VEGF and proteases in dengue shock syndrome. PLoS Negl Trop Dis 6: e1505.[Crossref]
  26. Conroy AL, Lafferty EI, Lovegrove FE, Krudsood S, Tangpukdee N, Liles WC, Kain KC, , 2009. Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria. Malar J 8: 295.[Crossref]
  27. Giuliano JS, Jr Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS, , 2007. Admission angiopoietin levels in children with septic shock. Shock 28: 650654.
  28. Giuliano JS, Jr Lahni PM, Bigham MT, Manning PB, Nelson DP, Wong HR, Wheeler DS, , 2008. Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass. Intensive Care Med 34: 18511857.[Crossref]
  29. Lee KW, Lip GY, Blann AD, , 2004. Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute coronary syndromes. Circulation 110: 23552360.[Crossref]
  30. Lim HS, Blann AD, Chong AY, Freestone B, Lip GY, , 2004. Plasma vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in diabetes: implications for cardiovascular risk and effects of multifactorial intervention. Diabetes Care 27: 29182924.[Crossref]
  31. Van der Heijden M, Pickkers P, van Nieuw Amerongen GP, van Hinsbergh VW, Bouw MP, van der Hoeven JG, Groeneveld AB, , 2009. Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality. Intensive Care Med 35: 15671574.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2012.12-0020
Loading
/content/journals/10.4269/ajtmh.2012.12-0020
Loading

Data & Media loading...

  • Received : 09 Jan 2012
  • Accepted : 17 Jul 2012

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error