Volume 86, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Because malaria is still a significant problem worldwide, additional control methods need to be developed. The sporozoite is a good target for control measures because it displays dual infectivity for both mosquito and vertebrate host tissues. The gene, , was chosen as a candidate for study based on data from PlasmoDB, the database, indicating that it is expressed both at the transcriptional and protein levels in sporozoites, likely encodes a putative surface protein, and may have a potential role in the invasion of host tissues. Additional sequence analysis shows that the PFE0565w protein has orthologs in other species, but none outside of the genus . expresses transcript during both the sporozoite and erythrocytic stages of the parasite life cycle, where an alternative transcript was discovered during the erythrocytic stages. Data show that transcript is not present during axenic exoerythrocytic stages. Despite transcript being present in several life cycle stages, the PFE0565w protein is present only during the salivary gland sporozoite stage. Because the PFE0565w protein is present in salivary gland sporozoites, it could be a novel candidate for a pre-erythrocytic stage vaccine.


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Supplementary PDF

  • Received : 22 Dec 2011
  • Accepted : 06 Feb 2012
  • Published online : 01 Jun 2012

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