Volume 86, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



To characterize clinical correlates of typhoid fever-associated encephalopathy, we performed a retrospective chart review of patients with serotype Typhi bacteremia who were hospitalized at the International Centre for Diarrhoeal Disease Research, Bangladesh, from February of 2009 to June of 2011. Of 207 patients bacteremic with Typhi who were ≥ 5 years of age, we identified 43 (21%) patients with encephalopathy. Univariate analysis revealed that patients with encephalopathy more often presented at ages of 10–24 years and had severe dehydration, low oxygen saturation, high respiratory rate, low leukocyte count, low platelet count, and Widal flagellar H agglutinin (TH) titer ≥ 1:640 compared with typhoid patients without encephalopathy. Multivariate analysis using logistic regression showed that age, dehydration, leukocyte count, and Widal TH titer were independently associated with encephalopathy. Our findings suggest that age, severity of disease, and immune responses are associated with encephalopathy during Typhi bacteremia, perhaps reflecting the impact of prominent inflammatory responses.


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  • Received : 02 Dec 2011
  • Accepted : 26 Jan 2012
  • Published online : 01 Apr 2012

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