Volume 86, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



is an emerging human pathogen associated primarily with the cat flea . In this study, we investigated the presence of in from Guatemala and Costa Rica. were collected directly from dogs and cats, and analyzed by polymerase chain reaction for -specific fragments of 17-kDa protein, OmpA, and citrate synthase genes. DNA was detected in 64% (55 of 86) and 58% (47 of 81) of flea pools in Guatemala and Costa Rica, respectively. Sequencing of A fragments identified genotype URRWXCal in samples from both countries, and genotype Rf2125 in Costa Rica. This is the first report of in Guatemala and of genotype Rf2125 in Costa Rica. The extensive presence of this pathogen in countries of Central America stresses the need for increased awareness and diagnosis.


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  1. Pérez-Osorio CE, Zavala-Velázquez JE, Arias León JJ, Zavala-Castro JE, , 2008. Rickettsia felis as emergent global threat for humans. Emerg Infect Dis 14: 10191023.[Crossref] [Google Scholar]
  2. Reif KE, Macaluso KR, , 2009. Ecology of Rickettsia felis: a review. J Med Entomol 46: 723736.[Crossref] [Google Scholar]
  3. Parola P, , 2011. Rickettsia felis: from a rare disease in the USA to a common cause of fever in sub-Saharan Africa. Clin Microbiol Infect 17: 9961000.[Crossref] [Google Scholar]
  4. Kelly PJ, Lucas H, Eremeeva ME, Dirks KG, Rolain JM, Yowell C, Thomas R, Douglas T, Dasch GA, Raoult D, , 2010. Rickettsia felis, West Indies. Emerg Infect Dis 16: 570571.[Crossref] [Google Scholar]
  5. Bermúdez CSE, Zaldívar AY, Spolidorio MG, Moraes-Filho J, Miranda RJ, Caballero CM, Mendoza Y, Labruna MB, , 2011. Rickettsial infection in domestic mammals and their ectoparasites in el Valle de Antón, Coclé, Panamá. Vet Parasitol 177: 134138.[Crossref] [Google Scholar]
  6. Hun L, Troyo A, Taylor L, Barbieri AM, Labruna MB, , 2011. First report of the isolation and molecular characterization of Rickettsia amblyommii and Rickettsia felis in Central America. Vector Borne Zoonotic Dis 11: 13951397.[Crossref] [Google Scholar]
  7. Labruna MB, Mattar VS, Nava S, Bermudez S, Venzal JM, Dolz G, Abarca K, Romero L, de Sousa R, Oteo J, Zavala-Castro J, , 2011. Rickettsioses in Latin America, Caribbean, Spain, and Portugal. Rev MVZ Córdoba 16: 24352457. [Google Scholar]
  8. Chen LH, Wilson ME, , 2009. Tick-borne rickettsiosis in traveler returning from Honduras. Emerg Infect Dis 15: 13211323. [Google Scholar]
  9. Peacock MG, Ormsbee RA, Johnson KM, , 1971. Rickettsioses of Central America. Am J Trop Med Hyg 20: 941949. [Google Scholar]
  10. Hun L, Cortes X, Taylor L, , 2008. Molecular characterization of Rickettsia rickettsii isolated from human clinical samples and from rabbit tick Haemaphysalis leporispalustris collected at different geographic zones in Costa Rica. Am J Trop Med Hyg 79: 899902. [Google Scholar]
  11. Massung RF, Davis LE, Slater K, McKechnie DB, Puerzer M, , 2001. Epidemic typhus meningitis in the southwestern United States. Clin Infect Dis 32: 979982.[Crossref] [Google Scholar]
  12. Estripeaut D, Aramburú MG, Sáez-Llorens X, Thompson HA, Dasch GA, Paddock CD, Zaki S, Eremeeva ME, , 2007. Rocky Mountain spotted fever, Panama. Emerg Infect Dis 13: 17631765.[Crossref] [Google Scholar]
  13. Eremeeva ME, Warashina WR, Sturgeon MM, Buchholz AE, Olmsted GK, Park SY, Effler PV, Karpathy SE, , 2008. Rickettsia typhi and R. felis in rat fleas (Xenopsylla cheopis), Oahu, Hawaii. Emerg Infect Dis 14: 16131615.[Crossref] [Google Scholar]
  14. Labruna MB, Whitworth T, Horta MC, Bouyer DH, McBride JW, Pinter A, Popov V, Gennari SM, Walker DH, , 2004. Rickettsia species infecting Amblyomma cooperi ticks from an area in the State of Sao Paulo, Brazil, where Brazilian spotted fever is endemic. J Clin Microbiol 42: 9098.[Crossref] [Google Scholar]
  15. Horta MC, Labruna MB, Pinter A, Linardi PM, Schumaker TT, , 2007. Rickettsia infection in five areas of the state of São Paulo, Brazil. Mem Inst Oswaldo Cruz 102: 793801.[Crossref] [Google Scholar]
  16. Labruna MB, Ogrzewalska M, Moraes-Filho J, Lepe P, Gallegos JL, López J, , 2007. Rickettsia felis in Chile. Emerg Infect Dis 13: 17941795.[Crossref] [Google Scholar]
  17. Forshey BM, Stewart A, Morrison AC, Gálvez H, Rocha C, Astete H, Eza D, Chen H, Chao C, Montgomery JM, Bentzel DE, Ching W, Kochel TJ, , 2010. Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon Basin of Peru. Am J Trop Med Hyg 82: 683690.[Crossref] [Google Scholar]
  18. Boostrom A, Beier MS, Macaluso JA, Macaluso KR, Sprenger D, Hayes J, Radulovic S, Azad AF, , 2002. Geographic association of Rickettsia felis-infected opossums with human murine typhus, Texas. Emerg Infect Dis 8: 549554.[Crossref] [Google Scholar]
  19. Venzal JM, Pérez-Martínez L, Félix ML, Portillo A, Blanco JR, Oteo JA, , 2006. Prevalence of Rickettsia felis in Ctenocephalides felis and Ctenocephalides canis from Uruguay. Ann N Y Acad Sci 1078: 305308.[Crossref] [Google Scholar]
  20. Reeves WK, Nelder MP, Korecki JA, , 2005. Bartonella and Rickettsia in fleas and lice from mammals in South Carolina, USA. J Vector Ecol 30: 310315. [Google Scholar]
  21. Richards AL, Jiang J, Omulo S, Dare R, Abdirahman K, Ali A, Sharif SK, Feikin DR, Brieman RF, Njenga MK, , 2010. Human infection with Rickettsia felis, Kenya. Emerg Infect Dis 16: 10811086.[Crossref] [Google Scholar]
  22. Socolovschi C, Mediannikov O, Sokhna C, Tall A, Diatta G, Bassene H, Trape JF, Raoult D, , 2010. Rickettsia felis–associated uneruptive fever, Senegal. Emerg Infect Dis 16: 11401142. [Google Scholar]
  23. Zavala-Castro J, Zavala-Velázquez J, Walker D, Pérez-Osorio J, Peniche-Lara G, , 2009. Severe human infection with Rickettsia felis associated with hepatitis in Yucatan, Mexico. Int J Med Microbiol 299: 529533.[Crossref] [Google Scholar]

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  • Received : 28 Nov 2011
  • Accepted : 04 Mar 2012
  • Published online : 01 Jun 2012

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