Volume 86, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We analyzed surveillance data of a dengue outbreak (2010) reported to the Hadramout Health Office (Yemen) and retrospectively analyzed dengue-related epidemiological and entomological events reported in Hadramout from 2005 to 2009. A total of 630 immunoglobulin M (IgM) -confirmed dengue cases of 982 febrile cases was reported during the period from February to June of 2010; 12 cases died, giving case fatality a rate of 1.9%. Among febrile cases, the highest proportion of dengue cases (37.3%) was reported in the 15- to 24-year-old age group. The overall attack rate was 0.89/1,000. The average number of cases reported by month over the preceding 5-year period compared with the 2010 data is consistent with endemicity of dengue in the region and supports epidemic designation for the dengue activity in 2010. Recognition of endemic dengue transmission and potential for substantial dengue epidemics highlight the need for consistent laboratory-based surveillance that can support prevention and control activities accordingly.


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  1. Christie J, , 1872. Dengue. BMJ 2: 244.[Crossref] [Google Scholar]
  2. Radcliffe JN, , 1877. Dengue. BMJ 1: 2526.[Crossref] [Google Scholar]
  3. World Health Organization, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control, New Ed. Geneva, Switzerland: World Health Organization. [Google Scholar]
  4. Jimenez-Lucho VE, Fisher EJ, Saravolatz LD, , 1984. Dengue with hemorrhagic manifestations: an imported case from the Middle East. Am J Trop Med Hyg 33: 650653. [Google Scholar]
  5. Ravanini P, Huhtamo E, Hasu E, Rosa F, Costantino S, Crobu MG, Ilaria V, Nicosia AM, Garavelli PL, Vapalahti O, , 2011. Imported dengue virus serotype 3, Yemen to Italy, 2010. Emerg Infect Dis 17: 929931.[Crossref] [Google Scholar]
  6. Amarasinghe A, Letson GW, , 2012. Dengue in the Middle East: a neglected and emerging disease of importance. Trans R Soc Trop Med Hyg 106: 12.[Crossref] [Google Scholar]
  7. Kabilan L, Velayutham T, Sundaram B, Tewari SC, Natarajan A, Rathnasamy R, Satyanarayana K, , 2004. Field- and laboratory-based active dengue surveillance in Chennai, Tamil Nadu, India: observations before and during the 2001 dengue epidemic. Am J Infect Control 32: 391396.[Crossref] [Google Scholar]
  8. Ayyub M, Khazindar AM, Lubbad EH, Barlas S, Alfi AY, Al-Ukayli S, , 2006. Characteristics of dengue fever in a large public hospital, Jeddah, Saudi Arabia. J Ayub Med Coll Abbottabad 18: 913. [Google Scholar]
  9. Khan E, Siddiqui J, Shakoor S, Mehraj V, Jamil B, Hasan R, , 2007. Dengue outbreak in Karachi, Pakistan, 2006: experience at a tertiary care center. Trans R Soc Trop Med Hyg 101: 11141119.[Crossref] [Google Scholar]
  10. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA, , 2002. Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol 156: 4051.[Crossref] [Google Scholar]
  11. Brown MG, Vickers IE, Salas RA, Smikle MF, , 2009. Seroprevalence of dengue virus antibodies in healthy Jamaicans. Hum Antibodies 18: 123126. [Google Scholar]
  12. Vong S, Khieu V, Glass O, Ly S, Duong V, Huy R, Ngan C, Wichmann O, Letson GW, Margolis HS, Buchy P, , 2010. Dengue incidence in urban and rural Cambodia: results from population-based active fever surveillance, 2006–2008. PLoS Negl Trop Dis 4: e903.[Crossref] [Google Scholar]
  13. Hunsperger EA, Yoksan S, Buchy P, Nguyen VC, Sekaran SD, Enria DA, Pelegrino JL, Vazquez S, Artsob H, Drebot M, Gubler DJ, Halstead SB, Guzman MG, Margolis HS, Nathanson C-M, Rizzo Lic NR, Bessoff KE, Kliks S, Peeling RW, , 2009. Evaluation of commercially available anti-dengue virus immunoglobulin M tests. Emerg Infect Dis 15: 436440.[Crossref] [Google Scholar]
  14. Scott TW, Morrison AC, Rothman A, , 2010. Vector dynamics and transmission of dengue virus: implications for dengue surveillance and prevention strategies: vector dynamics and dengue prevention. , ed. Current Topics in Microbiology And Immunology: Dengue Virus. Berlin, Germany: Springer, 115126. [Google Scholar]
  15. Shahin W, Nassar A, Kalkattawi M, Bokhari H, , 2009. Dengue fever in a tertiary hospital in Mukakah, Saudi Arabia. Dengue Bull 33: 3444. [Google Scholar]
  16. Guha-Sapir D, Schimmer B, , 2005. Dengue fever: new paradigms for a changing epidemiology. Emerg Themes Epidemiol 2: 1.[Crossref] [Google Scholar]
  17. El-Gilany A, Eldeib A, Hamman dS, , 2010. Clinico-epidemiological features of dengue fever in Saudi Arabia. Asian Pac J Trop Med 3: 220223.[Crossref] [Google Scholar]
  18. Fakeeh M, Zaki AM, , 2001. Virologic and serologic surveillance for dengue fever in Jeddah, Saudi Arabia, 1994–1999. Am J Trop Med Hyg 65: 764767. [Google Scholar]
  19. Nguyen TP, Luu LL, Vu TQ, Buisson Y, , 2011. Increase of entomological indices during the pre-epidemic period of dengue in Ben Tre, South Vietnam. Bull Soc Pathol Exot 104: 313320.[Crossref] [Google Scholar]
  20. Mohammad Azami NA, Salleh SA, Neoh HM, Syed SZ, Jamal R, , 2011. Dengue epidemic in Malaysia: not a predominately urban disease any more. BMC Res Notes 4: 216.[Crossref] [Google Scholar]
  21. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmanitiya S, Suntayakorn S, Rothman AL, Ennis FA, Nisalak A, , 1997. Dengue in the early febrile phase: viremia and antibody responses. J Infect Dis 176: 322330.[Crossref] [Google Scholar]
  22. Kao CL, King CC, Chao DY, Wu HL, Chang GJ, , 2005. Laboratory diagnosis of dengue virus infection: current and future perspectives in clinical diagnosis and public health. J Microbiol Immunol Infect 38: 516. [Google Scholar]
  23. Jarman RG, Nisalak A, Anderson BK, Klungthong C, Thaisomboonsuk B, Kaneechit W, Kalayanarooj S, Gibbons RV, , 2011. Factors influencing dengue virus isolation by C6/36 cell culture and mosquito inoculation of nested PCR-positive clinical samples. Am J Trop Med Hyg 84: 218223.[Crossref] [Google Scholar]

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  • Received : 19 Nov 2011
  • Accepted : 22 Feb 2012
  • Published online : 01 Jun 2012

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