Volume 86, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The purpose of the current study was to investigate the susceptibility of to praziquantel in low endemic foci of China. During the non-transmission period of schistosomiasis, a total of 43 of 1,242 subjects were identified as being infected with the parasite using parasitological stool examinations in two low-endemicity areas of China, with a prevalence rate of 3.46%. All stool-egg-positive subjects were treated with praziquantel in a single oral dose of 40 mg/kg or 30 mg/kg for two successive days. Six weeks post-treatment, no eggs were detected in the 43 treated villagers. The results indicate that the current efficacy of praziquantel against seems satisfactory and has not changed over the past three decades in the low endemic areas of China. It is also suggested that no evidence of tolerance or resistance to praziquantel in is detected in areas with low endemicity in China.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Engels D, Chitsulo L, Montresor A, Savioli L, , 2002. The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Trop 82: 139146.[Crossref] [Google Scholar]
  2. Wang LD, Utzinger J, Zhou XN, , 2008. Schistosomiasis control: experiences and lessons from China. Lancet 372: 17931795.[Crossref] [Google Scholar]
  3. Zhou XN, Wang LY, Chen MG, Wu XH, Jiang QW, Chen XY, Zheng J, Utzinger J, , 2005. The public health significance and control of schistosomiasis in China–then and now. Acta Trop 96: 97105.[Crossref] [Google Scholar]
  4. Zhou XN, Guo JG, Wu XH, Jiang QW, Zheng J, Dang H, Wang XH, Xu J, Zhu HQ, Wu GL, Li YS, Xu XJ, Chen HG, Wang TP, Zhu YC, Qiu DC, Dong XQ, Zhao GM, Zhang SJ, Zhao NQ, Xia G, Wang LY, Zhang SQ, Lin DD, Chen MG, Hao Y, , 2007. Epidemiology of schistosomiasis in the People's Republic of China, 2004. Emerg Infect Dis 13: 14701476.[Crossref] [Google Scholar]
  5. World Health Organization, 2002. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. WHO Technical Report Series 912. Geneva: WHO.
  6. Xiao SH, Keiser J, Chen MG, Tanner M, Utzinger J, , 2010. Research and development of antischistosomal drugs in the People's Republic of China: a 60-year review. Adv Parasitol 73: 231295.[Crossref] [Google Scholar]
  7. Chen MG, , 2005. Use of praziquantel for clinical treatment and morbidity control of schistosomiasis japonica in China: a review of 30 years' experience. Acta Trop 96: 168176.[Crossref] [Google Scholar]
  8. Fallon PG, Doenhoff MJ, , 1994. Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am J Trop Med Hyg 51: 8388. [Google Scholar]
  9. Liang YS, Li HJ, Dai JR, Wang W, Qu GL, Tao YH, Xing YT, Li YZ, Qian K, Wei JY, , 2011. Resistance of Schistosoma japonicum to praziquantel is experimentally induced in laboratory. Chin J Schisto Control 23: 605610. [Google Scholar]
  10. Ismail M, Metwally A, Farghaly A, Bruce J, Tao LF, Bennett JL, , 1996. Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am J Trop Med Hyg 55: 214218. [Google Scholar]
  11. Ismail M, Botros S, Metwally A, William S, Farghally A, Tao LF, Day TA, Bennett JL, , 1999. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60: 932935. [Google Scholar]
  12. Fallon PG, Sturrock RF, Niang AC, Doenhoff MJ, , 1995. Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni . Am J Trop Med Hyg 53: 6162. [Google Scholar]
  13. Melman SD, Steinauer ML, Cunningham C, Kubatko LS, Mwangi IN, Wynn NB, Mutuku MW, Karanja DM, Colley DG, Black CL, Secor WE, Mkoji GM, Loker ES, , 2009. Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni . PLoS Negl Trop Dis 3: e504.[Crossref] [Google Scholar]
  14. Herwaldt BL, Tao LF, van Pelt W, Tsang VC, Bruce JI, , 1995. Persistence of Schistosoma haematobium infection despite multiple courses of therapy with praziquantel. Clin Infect Dis 20: 309315.[Crossref] [Google Scholar]
  15. Alonso D, Muñoz J, Gascón J, Valls ME, Corachan M, , 2006. Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection. Am J Trop Med Hyg 74: 342344. [Google Scholar]
  16. Yu DB, Li Y, Sleigh AC, Yu XL, Li YS, Wei WY, Liang YS, McManus DP, , 2001. Efficacy of praziquantel against Schistosoma japonicum: field evaluation in an area with repeated chemotherapy compared with a newly identified endemic focus in Hunan, China. Trans R Soc Trop Med Hyg 95: 537541.[Crossref] [Google Scholar]
  17. Liang YS, Dai JR, Ning A, Yu DB, Xu XJ, Zhu YC, Coles GC, , 2001. Susceptibility of Schistosoma japonicum to praziquantel in China. Trop Med Int Health 6: 707714.[Crossref] [Google Scholar]
  18. Wang W, Dai JR, Li HJ, Shen XH, Liang YS, , 2010. Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China. Parasitology 137: 19051912.[Crossref] [Google Scholar]
  19. Balen J, Zhao ZY, Williams GM, McManus DP, Raso G, Utzinger J, Zhou J, Li YS, , 2007. Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China. Bull World Health Organ 85: 519526.[Crossref] [Google Scholar]
  20. Hong QB, Yang K, Huang YX, Sun LP, Yang GJ, Gao Y, Gao Y, Zhang LH, Zhou M, Steinmann P, Liang YS, , 2011. Effectiveness of a comprehensive schistosomiasis japonica control program in Jiangsu province, China, from 2005 to 2008. Acta Trop 120S: S151S157.[Crossref] [Google Scholar]
  21. Chen XY, Wang LY, Cai JM, Zhou XN, Zheng J, Guo JG, Wu XH, Engels D, Chen MG, , 2005. Schistosomiasis control in China: the impact of a 10-year World Bank Loan Project (1992–2001). Bull World Health Organ 83: 4348. [Google Scholar]
  22. Yu S, , 1981. Studies on the methodology of egg collection with nylon bag for the diagnosis of Schistosoma japonicum infections. Chin J Med Lab Technol 4: 210213. [Google Scholar]
  23. Gönnert R, Andrews P, , 1977. Praziquantel, a new broad-spectrum antischistosomal agent. Z Parasitenkd 52: 129150.[Crossref] [Google Scholar]
  24. Jordan P, Webbe G, Sturrock RF, , 1993. Human Schistosomiasis. UK: CAB International. [Google Scholar]
  25. Wu GL, , 2002. A historical perspective on the immunodiagnosis of schistosomiasis in China. Acta Trop 82: 193198.[Crossref] [Google Scholar]
  26. Zhu YC, , 2005. Immunodiagnosis and its role in schistosomiasis control in China: a review. Acta Trop 96: 130136.[Crossref] [Google Scholar]
  27. Katz N, Chaves A, Pellegrino J, , 1972. A simple device for quantitative stool thick-smear techniques in schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo 14: 397400. [Google Scholar]
  28. Lin DD, Liu JX, Liu YM, Hu F, Zhang YY, Xu JM, Li JY, Ji MJ, Bergquist R, Wu GL, Wu HW, , 2008. Routine Kato-Katz technique underestimates the prevalence of Schistosoma japonicum: a case study in an endemic area of the People's Republic of China. Parasitol Int 57: 281286.[Crossref] [Google Scholar]
  29. Yu JM, de Vlas SJ, Jiang QW, Gryseels B, , 2007. Comparison of the Kato-Katz technique, hatching test and indirect hemagglutination assay (IHA) for the diagnosis of Schistosoma japonicum infection in China. Parasitol Int 56: 4549.[Crossref] [Google Scholar]

Data & Media loading...

  • Received : 09 Nov 2011
  • Accepted : 22 Dec 2011
  • Published online : 01 May 2012

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error