Volume 86, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We report the first documented case of a mycetoma caused by after the initial description of this species. The 16S-rRNA gene sequence analysis was used to identify the novel species, which showed a similarity of 99.9% to the gene sequence of the type strain. The case showed both clinical non-response and reduced susceptibility to amoxicillin plus clavulanate, and it was treated successfully with trimethoprim-sulfamethoxazole and doxycycline. Given antibiotic resistance concerns, we suggest that antimicrobial susceptibility testing should be done for the majority of species without well-established resistance patterns.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Kageyama A, Yazawa K, Nishimura K, Mikami Y, , 2004. Nocardia inohanensis sp. nov., Nocardia yamanashiensis sp. nov. and Nocardia niigatensis sp. nov., isolated from clinical specimens Int J Syst Evol Microbiol 54: 563569.[Crossref] [Google Scholar]
  2. Satterwhite TK, Wallace RJ, , 1979. Primary cutaneous nocardiosis. JAMA 242: 333336.[Crossref] [Google Scholar]
  3. Maraki S, Chochlidakis S, Nioti E, Tselentis Y, , 2004. Primary lymphocutaneous nocardiosis in an immunocompetent patient. Ann Clin Microbiol Antimicrob 15: 24.[Crossref] [Google Scholar]
  4. Tellez I, Franco-Paredes C, , 2010. A woman with chronic subcutaneous swelling of the right foot associated with sinus tracts discharging yellow grains. PLoS Negl Trop Dis 4: e772.[Crossref] [Google Scholar]
  5. CLSI, 2011. Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes: Approved Standard—Second Edition. CLSI document M24-A2. Wayne, PA: Clinical and Laboratory Standards Institute. [Google Scholar]
  6. Conville P, Witebsky FG, , 2007. Analysis of multiple differing copies of the 16S rRNA gene in five clinical isolates and three type strains of Nocardia species and implications for species assignment. J Clin Microbiol 45: 11461151.[Crossref] [Google Scholar]
  7. Sorrel TC, Mitchell DH, Iredell JR, Mandell GL, Bennett JE, Dolin R, , 2010. Nocardia species. , eds. Principles and Practice of Infectious Diseases. Seventh edition. Philadelphia, PA: Churchill Livingstone Elsevier, 31993207. [Google Scholar]
  8. Adhikari L, Dey S, Pal R, , 2010. Mycetoma due to Nocardia farcinica . J Glob Infect Dis 2: 194195.[Crossref] [Google Scholar]
  9. Clark N, Braun D, Pasternak A, Chenoweth C, , 1995. Primary cutaneous Nocardia otitidiscaviarum infection: case report and review. Clin Infect Dis 20: 12661270.[Crossref] [Google Scholar]
  10. Shimizu A, Ishikawa O, Nagai Y, Mikami Y, Nishimura K, , 2001. Primary cutaneous nocardiosis due to Nocardia nova in a healthy woman. Br J Dermatol 145: 154156.[Crossref] [Google Scholar]
  11. Rodríguez-Nava V, Couble A, Molinard C, Sandoval H, Boiron P, Laurent F, , 2004. Nocardia mexicana sp. nov., a new pathogen isolated from human mycetomas. J Clin Microbiol 42: 45304535.[Crossref] [Google Scholar]
  12. Steingrube VA, Wallace RJ, Jr Brown BA, Pang Y, Zeluff B, Steele LC, , 1991. Acquired resistance of Nocardia brasiliensis to clavulanic acid related to a change in beta-lactamase following therapy with amoxicillin-clavulanic acid. Antimicrob Agents Chemother 35: 524528.[Crossref] [Google Scholar]

Data & Media loading...

  • Received : 27 Oct 2011
  • Accepted : 01 Dec 2011
  • Published online : 01 Jun 2012

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error