Volume 88, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



sp is an intracellular parasite that causes a variable degree of clinical manifestations, especially in the skin. We present the case of a 38-year-old male with a chronic history of mucocutaneous disease present since childhood that generated deformity, loss of cartilage in the ears and nose, and scarring that limited his range of motion. The parasite was identified as . The patient was treated with a 3-month course of oral miltefosine with overwhelming results.


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  1. Maroli M, Khoury C, , 2004. Prevention and control of leishmaniasis vectors: current approaches. Parassitologia 46: 211215. [Google Scholar]
  2. World Health Organization. Control of Leishmaniases. Report of a Meeting of the WHO Expert Committee on the Control of Leishmaniases. Available at: http://whqlibdoc.who.int/trs/WHO_TRS_949_eng.pdf. Accessed August 2, 2012. [Google Scholar]
  3. Mondal S, Bhattacharya P, Ali N, , 2010. Current diagnosis and treatment of visceral leishmaniasis. Expert Rev Anti Infect Ther 8: 919944.[Crossref] [Google Scholar]
  4. Richard JV, Werbovetz KA, , 2010. New antileishmanial candidates and lead compounds. Curr Opin Chem Biol 14: 447455.[Crossref] [Google Scholar]
  5. Almeida OL, Santos JB, , 2011. Advances in the treatment of cutaneous leishmaniasis in the new world in the last ten years: asystematic literature review. An Bras Dermatol 86: 497506.[Crossref] [Google Scholar]
  6. Zerpa O, Ulrich M, Blanco B, Polegre M, Avila A, Matos N, Mendoza I, Pratlong F, Ravel C, Convit J, , 2007. Diffuse cutaneous leishmaniasis responds to miltefosine but then relapses. Br J Dermatol 156: 13281335.[Crossref] [Google Scholar]
  7. Turetz ML, Machado PR, Ko AI, Alves F, Bittencourt A, Almeida RP, Mobashery N, Johnson WD, Jr Carvalho EM, , 2002. Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil. J Infect Dis 186: 18291834.[Crossref] [Google Scholar]
  8. Ruiz JH, Becker I, , 2007. CD8 cytotoxic T cells in cutaneous leishmaniasis. Parasite Immunol 29: 671678.[Crossref] [Google Scholar]
  9. Hernández-Ruiz J, Salaiza-Suazo N, Carrada G, Escoto S, Ruiz Remigio A, Rosenstein Y, Zentella A, Becker I, , 2010. CD8 cells of patients with diffuse cutaneous leishmaniasis display funconal exhaustion: the latteris reversed, in vitro, by TLR2 agonists. PLoS Negl Trop Dis 4: e871.[Crossref] [Google Scholar]
  10. Mayrink W, Botelho AC, Magalhães PA, Batista SM, Lima A de O, Genaro O, Costa CA, Melo MN, Michalick MS, Williams P, Dias M, Caiaffa WT, Nascimento E, Machado-Coelho GL, , 2006. Immunotherapy, immunochemotherapy and chemotherapy for American cutaneous leishmaniasis treatment. Rev Soc Bras Med Trop 39: 1421.[Crossref] [Google Scholar]
  11. Pereira LI, Dorta ML, Pereira AJ, Bastos RP, Oliveira MA, Pinto SA, Galdino H, Jr Mayrink W, Barcelos W, Toledo VP, Lima GM, Ribeiro-Dias F, , 2009. Increase of NK cells and proinflammatory monocytes are associated with the clinical improvementof diffuse cutaneous leishmaniasis after immunochemotherapy with BCG/Leishmania antigens. Am J Trop Med Hyg 81: 378383. [Google Scholar]
  12. Okwor I, Uzonna JE, , 2009. Immunotherapy as a strategy for treatment of leishmaniasis: a review of the literature. Immunotherapy. 1: 765776.[Crossref] [Google Scholar]
  13. Simpson MH, Mullins JF, Stone OJ, , 1968. An Autochthonous Case in Texas and the Mexican States of Tamaulipas and Nuevo Leon. Arch Dermatol 97: 301303.[Crossref] [Google Scholar]
  14. Trainor KE, Porter BF, Logan KS, Hoffman RJ, Snowden KF, , 2010. Eight cases of feline cutaneous leishmaniasis in Texas. Vet Pathol 47: 10761081.[Crossref] [Google Scholar]
  15. McHugh CP, , 2010. Cutaneous leishmaniasis in Texas. J Am Acad Dermatol 62: 508510.[Crossref] [Google Scholar]
  16. Wright NA, Davis LE, Aftergut KS, Parrish CA, Cockerell CJ, , 2008. Cutaneous leishmaniasis in Texas: a northern spread of endemic areas. J Am Acad Dermatol 58: 650652.[Crossref] [Google Scholar]
  17. Nilforoushzadeh MA, Jaffary F, Ansari N, Siadat AH, Nilforoushan Z, Firouz A, , 2008. A comparative study between the efficacy of systemic meglumineantimoniate therapy with standard or low dose plus omeprazole in the treatment of cutaneous leishmaniasis. J Vector Borne Dis 45: 287291. [Google Scholar]
  18. Van Griensven J, Balasegaram M, Meheus F, Alvar J, Lynen L, Boelaert M, , 2010. Combination therapy for visceral leishmaniasis. Lancet Infect Dis 10: 184194.[Crossref] [Google Scholar]
  19. Shakya N, Sane SA, Vishwakarma P, Bajpai P, Gupta S, , 2011. Improved treatment of visceral leishmaniasis (kala-azar) by using combination of ketoconazole, miltefosine with an immunomodulator-Picroliv. Acta Trop 119: 188193.[Crossref] [Google Scholar]
  20. Shamsi Meymandi S, Javadi A, Dabiri S, Shamsi Meymandi M, Nadji M, , 2011. Comparative histological and immunohistochemical changes of dry type cutaneous leishmaniasis after administration of meglumineantimoniate, imiquimod or combination therapy. Arch Iran Med 14: 238243. [Google Scholar]
  21. Kashani MN, , 2007. Evaluation of meglumineantimoniate effects on liver, kidney and pancreas function tests in patients with cutaneous leishmaniasis. Eur J Dermatol 17: 513515. [Google Scholar]
  22. Soto J, Toledo J, Valda L, Balderrama M, Rea I, Parra R, Ardiles J, Soto P, Gomez A, Molleda F, Fuentelsaz C, Anders G, Sindermann H, Engel J, Berman J, , 2007. Treatment of Bolivian mucosal leishmaniasis with miltefosine. Clin Infect Dis 44: 350356.[Crossref] [Google Scholar]
  23. Calvopina M, Gomez E, Sindermann H, Cooper P, Hashiguchi Y, , 2006. Relapse of new world diffuse cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana after miltefosine treatment. Am J Trop Med Hyg 75: 10741077. [Google Scholar]

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  • Received : 21 Sep 2011
  • Accepted : 11 Sep 2012
  • Published online : 09 Jan 2013

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