1921
Volume 86, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We report a successful treatment of severe falciparum malaria in a non-immune adult patient with 30% parasitemia treated with the 6-dose oral regimen of artemether plus lumefantrine combination therapy alone. We have also retrospectively searched our tertiary center's database for similar cases and we have found two additional severe malaria cases, resolved uneventfully with oral regimen. These cases might indicate a need to specifically address the definition of severe and complicated malaria in non-immune patients either in designated guidelines or as an explicit addition to the historical World Health Organization criteria.

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2012-03-01
2017-11-25
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References

  1. World Health Organization, 2010. Guidelines for the Treatment of Malaria. Second edition. Geneva, Switzerland: World Health Organization. Available at: http://whqlibdoc.who.int/publications/2010/9789241547925_eng.pdf Accessed July 15, 2011.
  2. World Health Organization, 2000. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 94 (Suppl 1): S1S90.
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  4. World Health Organization, 1990. Severe and complicated malaria. World Health Organization, Division of Control of Tropical Diseases. Trans R Soc Trop Med Hyg 84 (Suppl 2): 165.
  5. Day N, Dondorp AM, , 2007. The management of patients with severe malaria. Am J Trop Med Hyg 77 (Suppl 6): 2935.
  6. Omari AA, Gamble C, Garner P, , 2005. Artemether-lumefantrine (six-dose regimen) for treating uncomplicated falciparum malaria. Cochrane Database Syst Rev CD005564.
  7. Hatz C, Soto J, Nothdurft HD, Zoller T, Weitzel T, Loutan L, Bricaire F, Gay F, Burchard GD, Andriano K, Lefèvre G, De Palacios PI, Genton B, , 2008. Treatment of acute uncomplicated falciparum malaria with artemether-lumefantrine in nonimmune populations: a safety, efficacy, and pharmacokinetic study. Am J Trop Med Hyg 78: 241247.
  8. Novartis, 2010. Coartem monograph . Eighth edition. Basel, Switzerland: Novartis Pharma AG. Available at: http://www.coartem.com/product-monograph.htm. Accessed July 15, 2011.
  9. Sinclair D, Donegan S, Lalloo DG, , 2011. Artesunate versus quinine for treating severe malaria. Cochrane Database Syst Rev CD005967.
  10. Balint GA, , 2001. Artemisinin and its derivatives: an important new class of antimalarial agents. Pharmacol Ther 90: 261265.[Crossref]
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  • Received : 07 Sep 2011
  • Accepted : 09 Nov 2011

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