Volume 86, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



African histoplasmosis, caused by var. , is endemic in Africa. The disease usually involves the skin, subcutaneous tissue, and bones. A case of African histoplasmosis presenting as a cutaneous tumor and non-healing wound in a 66-year-old immunocompetent male residing in Africa, the first ever reported following mudbaths and acupuncture, is hereby reported. Diagnosis was confirmed by means of polymerase chain reaction performed on tissue material. The patient was started on long-term itraconazole therapy and he responded well. African histoplasmosis should be included in the differential diagnosis of non-healing wounds or tumor-like lesions, especially in the context of mudbaths in an endemic area.


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  1. Gugnani HC, , 2000. Histoplasmosis in Africa: a review. Indian J Chest Dis Allied Sci 42: 271277. [Google Scholar]
  2. Nethercott JR, Schachter RK, Givan KE, Ryder DE, , 1978. Histoplasmosis due to Histoplasma capsulatum var. duboisii in a Canadian immigrant. Arch Dermatol 114: 595598.[Crossref] [Google Scholar]
  3. Loulergue P, Bastides F, Baudouin V, Chandenier J, Mariani-Kurkdjian P, Dupont B, Viard J-P, Dromer F, Lortholary O, , 2007. Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients. Emerg Infect Dis 13: 16471652.[Crossref] [Google Scholar]
  4. Buitrago MJ, Berenguer J, Mellado E, Rodríguez-Tudela JL, Cuenca-Estrella M, , 2006. Detection of imported histoplasmosis in serum of HIV-infected patients using a real-time PCR-based assay. Eur J Clin Microbiol Infect Dis 10: 665668.[Crossref] [Google Scholar]
  5. Dubois A, Janssens PG, Brutsaert P, Vanbreuseghem R, , 1952. A case of African histoplasmosis; with a mycological note on Histoplasma duboisii n. sp. [in French, Un cas d? histoplasmose africaine. Avec une note mycologique sur Histoplasma duboisii n. sp.]. Ann Soc Belge Med Trop 32: 569584. [Google Scholar]
  6. Gugnani HC, Muotoe-Okafor F, , 1997. African histoplasmosis: a review. Rev Iberoam Micol 14: 155159. [Google Scholar]
  7. Zarnowski R, Miyazaki M, Dobrzyn A, Ntambi JM, Woods JP, , 2007. Typing of Histoplasma capsulatum strains by fatty acid profile analysis. J Med Microbiol 56: 788797.[Crossref] [Google Scholar]
  8. Minta DK, Dembélé M, Lorre G, Diallo DA, Traoré HA, Chabasse D, , 2005. African histoplasmosis (Histoplasma capsulatum var. duboisii): a case report from Mali [in French, Histoplasmose Africaine à Histoplasma capsulatum var. duboisii. A propos d? un cas au Mali]. Cahiers Santé 15: 195199. [Google Scholar]
  9. Binford CH, Dooley JR, , 1976. African histoplasmosis. Binford CH, Connor DH, eds. Pathology of Tropical and Extraordinary Diseases. Volume 2.: Washington DC: Armed Forces Institute of Pathology, 581583. [Google Scholar]
  10. Mudawi HM, Elamin EM, Baraka OZ, El-Hassan AM, , 2008. Addison’s disease due to Histoplasma duboisii infection of the adrenal glands. Saudi Med J 29: 904906. [Google Scholar]
  11. Sanguino JC, Rodrigues B, Baptista A, Quina M, , 1996. Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. Hepatogastroenterology 43: 771775. [Google Scholar]
  12. Pequignot H, Abelanet R, Christoforov B, Drouhet E, Duflo B, Gorin JP, Lapierre J, de Saint-Maur P, Tran-Vinh-Hien, 1972. Peritonitis due to perforation of intestinal histoplasmosis due to Histoplasma duboisii [in French, Péritonite par perforation d?une histoplasmose intestinale à Histoplasma duboisii]. Ann Med Interne (Paris) 123: 981986. [Google Scholar]
  13. Khalil M, Iwatt AR, Gugnani HC, , 1989. African histoplasmosis masquerading as carcinoma of the colon: report of a case and review of the literature. Dis Colon Rectum 32: 518520.[Crossref] [Google Scholar]
  14. Bansal RK, Suseelan AV, Gugnani HC, , 1977. Orbital cyst due to Histoplasma duboisii . Br J Ophthalmol 61: 7071.[Crossref] [Google Scholar]
  15. Weedon D, , 2010. Mycoses and algal infections. Weedon’s Skin Pathology. Third edition. Churchill Livingstone Elsevier, 581606. [Google Scholar]
  16. McKee PH, Calonje E, Grayson W, McKee PH, Calonje E, Granter SR, , 2005. Infectious diseases of the skin. , eds. Pathology of the Skin with Clinical Correlations. Volume 1, Third edition. Philadephia, PA: Elsevier Mosby, 837992. [Google Scholar]
  17. Chandler FW, Kaplan W, Ajello L, , 1980. Histoplasmosis duboisii. A Colour Atlas and Textbook of the Histopathology of Mycotic Diseases. London: Wolfe Medical Publications Ltd., 6769. [Google Scholar]
  18. Prieto-Granada CN, Lobo AZC, Mihm MC, Jr Kradin RL, , 2010. Skin infections. , ed. Diagnostic Pathology of Infectious Disease. Saunders Elsevier, 519616.[Crossref] [Google Scholar]
  19. White CL, Bancroft JD, Gamble M, , 2008. Immunohistochemistry applications in pathology. , eds. Theory and Practice of Histological Techniques. Sixth edition. Churchill Livingstone Elsevier, 493516.[Crossref] [Google Scholar]
  20. Oguachuba HN, Gugnani HC, , 1982. African histoplasmosis manifesting as a cutaneous tumour treated with econazole. J Trop Med Hyg 85: 259263. [Google Scholar]
  21. Wheat LJ, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, Kauffman CA, , 2007. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 45: 807825.[Crossref] [Google Scholar]

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  • Received : 01 Sep 2011
  • Accepted : 21 Oct 2011
  • Published online : 01 Feb 2012

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