1921
Volume 86, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Mannose-binding lectin (MBL) and Toll-like receptor (TLR) polymorphisms may influence susceptibility and manifestation of infection. In northern Chile, we examined 61 asymptomatic patients with chronic Chagas disease (CD), 64 patients with chronic Chagas cardiomyopathy (CCC), and 45 healthy individuals. Low-producer genotypes were more common in CD patients (48%) than healthy individuals (31%; adjusted odds ratio = 2.3, 95% confidence interval = 1.01–5.4, = 0.047) but did not differ with manifestation. In contrast, the heterozygous ()-deficiency genotype D299G/T399I occurred more frequently in asymptomatic (14.8%) than CCC patients (3.1%; = 0.02). -I602S, -R753Q, -S249P, and -S180L did not associate with CD or CCC. These findings support the complement system to be involved in defense against infection and indicate that curbed TLR4 activation might be beneficial in preventing CCC.

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  • Received : 22 Aug 2011
  • Accepted : 22 Oct 2011

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