1921
Volume 87, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We analyzed the intensity of inflammation and parasitism in BALB/c mice infected with I stocks from Mexico with and without benznidazole treatment in the acute phase of disease. Heart and skeletal muscles were evaluated for parasites and inflammation and blood was evaluated for persistence of circulating parasites. Parasitemia was influenced by stocks used and benznidazole treatment. This treatment cleared circulating parasites three days after starting treatment when monitored by direct microscopy. There was a significant reduction of inflammation in skeletal muscles after benznidazole treatment in animals infected with Mexican I stocks ( < 0.05), but this reduction was not significant in the heart ( > 0.05). I parasites from Mexico were demonstrated by polymerase chain reaction in tissues and blood of animals after benznidazole treatment.

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2012-10-03
2017-09-20
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  • Received : 11 Aug 2011
  • Accepted : 10 Jul 2012

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