1921
Volume 87, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating exposure. Our objective was to evaluate specific antibody responses to saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children and steadily waned with age. Specific IgG levels were significantly higher in persons living in sites with higher density, as measured by using entomologic parameters. Logistic regression showed a significant correlation between IgG to saliva and exposure level, independently of either age or sex. These results suggest that antibody responses to saliva could be used to monitor human exposure to bites.

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References

  1. Paupy C, Delatte H, Bagny L, Corbel V, Fontenille D, , 2009. Aedes albopictus, an arbovirus vector: from the darkness to the light. Microbes Infect 11: 11771185.[Crossref] [Google Scholar]
  2. Renault P, Solet JL, Sissoko D, Balleydier E, Larrieu S, Filleul L, Lassalle C, Thiria J, Rachou E, de Valk H, Ilef D, Ledrans M, Quatresous I, Quenel P, Pierre V, , 2007. A major epidemic of chikungunya virus infection on Reunion Island, France, 2005–2006. Am J Trop Med Hyg 77: 727731. [Google Scholar]
  3. Rezza G, Nicoletti L, Angelini R, Romi R, Finarelli AC, Panning M, Cordioli P, Fortuna C, Boros S, Magurano F, Silvi G, Angelini P, Dottori M, Ciufolini MG, Majori GC, Cassone A, , 2007. Infection with chikungunya virus in Italy: an outbreak in a temperate region. Lancet 370: 18401846.[Crossref] [Google Scholar]
  4. Roca Y, Baronti C, Revollo RJ, Cook S, Loayza R, Ninove L, Fernandez RT, Flores JV, Herve JP, de Lamballerie X, , 2009. Molecular epidemiological analysis of dengue fever in Bolivia from 1998 to 2008. Vector Borne Zoonotic Dis 9: 337344.[Crossref] [Google Scholar]
  5. Ligon BL, , 2006. Infectious diseases that pose specific challenges after natural disasters: a review. Semin Pediatr Infect Dis 17: 3645.[Crossref] [Google Scholar]
  6. Mackenzie JS, Gubler DJ, Petersen LR, , 2004. Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses. Nat Med 10: S98S109.[Crossref] [Google Scholar]
  7. Barbazan P, Tuntaprasart W, Souris M, Demoraes F, Nitatpattana N, Boonyuan W, Gonzalez JP, , 2008. Assessment of a new strategy, based on Aedes aegypti (L.) pupal productivity, for the surveillance and control of dengue transmission in Thailand. Ann Trop Med Parasitol 102: 161171.[Crossref] [Google Scholar]
  8. Focks DA, Chadee DD, , 1997. Pupal survey: an epidemiologically significant surveillance method for Aedes aegypti: an example using data from Trinidad. Am J Trop Med Hyg 56: 159167. [Google Scholar]
  9. Tun-Lin W, Kay BH, Barnes A, Forsyth S, , 1996. Critical examination of Aedes aegypti indices: correlations with abundance. Am J Trop Med Hyg 54: 543547. [Google Scholar]
  10. Billingsley PF, Baird J, Mitchell JA, Drakeley C, , 2006. Immune interactions between mosquitoes and their hosts. Parasite Immunol 28: 143153.[Crossref] [Google Scholar]
  11. Remoue FC, Ngom S, Boulager A, Simondon F, Garraud O, Fort PO, , 2005. Immune responses to arthropod bites during vector-borne diseases. , eds. Update in Tropical Immunology. Tivandrum, Herala, India: Transworld Research Network, 377400. [Google Scholar]
  12. Ribeiro JM, , 1995. Blood-feeding arthropods: live syringes or invertebrate pharmacologists? Infect Agents Dis 4: 143152. [Google Scholar]
  13. Ribeiro JM, Francischetti IM, , 2003. Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives. Annu Rev Entomol 48: 7388.[Crossref] [Google Scholar]
  14. Nascimento R, Santana J, Lozzi S, Araujo C, Teixeira A, , 2001. Human IgG1 and IgG4: the main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins. Am J Trop Med Hyg 65: 219226. [Google Scholar]
  15. Schwartz BS, Ribeiro JM, Goldstein MD, , 1990. Anti-tick antibodies: an epidemiologic tool in Lyme disease research. Am J Epidemiol 132: 5866.[Crossref] [Google Scholar]
  16. Poinsignon A, Remoue F, Rossignol M, Cornelie S, Courtin D, Grebaut P, Garcia A, Simondon F, , 2008. Human IgG antibody response to Glossina saliva: an epidemiologic marker of exposure to Glossina bites. Am J Trop Med Hyg 78: 750753. [Google Scholar]
  17. Das MK, Mishra A, Beuria MK, Dash AP, , 1991. Human natural antibodies to Culex quinquefasciatus: age-dependent occurrence. J Am Mosq Control Assoc 7: 319321. [Google Scholar]
  18. Trevejo RT, Reeves WC, , 2005. Antibody response to Culex tarsalis salivary gland antigens among sentinel chickens in California. Am J Trop Med Hyg 72: 481487. [Google Scholar]
  19. Remoue F, Cisse B, Ba F, Sokhna C, Herve JP, Boulanger D, Simondon F, , 2006. Evaluation of the antibody response to Anopheles salivary antigens as a potential marker of risk of malaria. Trans R Soc Trop Med Hyg 100: 363370.[Crossref] [Google Scholar]
  20. Waitayakul A, Somsri S, Sattabongkot J, Looareesuwan S, Cui L, Udomsangpetch R, , 2006. Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailand. Acta Trop 98: 6673.[Crossref] [Google Scholar]
  21. Andrade BB, Rocha BC, Reis-Filho A, Camargo LM, Tadei WP, Moreira LA, Barral A, Barral-Netto M, , 2009. Anti-Anopheles darlingi saliva antibodies as marker of Plasmodium vivax infection and clinical immunity in the Brazilian Amazon. Malar J 8: 121.[Crossref] [Google Scholar]
  22. Peng Z, Simons FE, , 2004. Mosquito allergy: immune mechanisms and recombinant salivary allergens. Int Arch Allergy Immunol 133: 198209.[Crossref] [Google Scholar]
  23. Brummer-Korvenkontio H, Palosuo K, Palosuo T, Brummer-Korvenkontio M, Leinikki P, Reunala T, , 1997. Detection of mosquito saliva-specific IgE antibodies by capture ELISA. Allergy 52: 342345.[Crossref] [Google Scholar]
  24. Peng Z, Rasic N, Liu Y, Simons FE, , 2002. Mosquito saliva-specific IgE and IgG antibodies in 1,059 blood donors. J Allergy Clin Immunol 110: 816817.[Crossref] [Google Scholar]
  25. Reunala T, Brummer-Korvenkontio H, Palosuo K, Miyanij M, Ruiz-Maldonado R, Love A, Francois G, Palosuo T, , 1994. Frequent occurrence of IgE and IgG4 antibodies against saliva of Aedes communis and Aedes aegypti mosquitoes in children. Int Arch Allergy Immunol 104: 366371.[Crossref] [Google Scholar]
  26. Orlandi-Pradines E, Almeras L, Denis de Senneville L, Barbe S, Remoue F, Villard C, Cornelie S, Penhoat K, Pascual A, Bourgouin C, Fontenille D, Bonnet J, Corre-Catelin N, Reiter P, Pages F, Laffite D, Boulanger D, Simondon F, Pradines B, Fusai T, Rogier C, , 2007. Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa. Microbes Infect 9: 14541462.[Crossref] [Google Scholar]
  27. Remoue F, Alix E, Cornelie S, Sokhna C, Cisse B, Doucoure S, Mouchet F, Boulanger D, Simondon F, , 2007. IgE and IgG4 antibody responses to Aedes saliva in African children. Acta Trop 104: 108115.[Crossref] [Google Scholar]
  28. Barrera R, , 2009. Simplified pupal surveys of Aedes aegypti (L.) for entomologic surveillance and dengue control. Am J Trop Med Hyg 81: 100107. [Google Scholar]
  29. De Benedictis J, Chow-Shaffer E, Costero A, Clark GG, Edman JD, Scott TW, , 2003. Identification of the people from whom engorged Aedes aegypti took blood meals in Florida, Puerto Rico, using polymerase chain reaction-based DNA profiling. Am J Trop Med Hyg 68: 437446. [Google Scholar]
  30. Michael E, Ramaiah KD, Hoti SL, Barker G, Paul MR, Yuvaraj J, Das PK, Grenfell BT, Bundy DA, , 2001. Quantifying mosquito biting patterns on humans by DNA fingerprinting of bloodmeals. Am J Trop Med Hyg 65: 722728. [Google Scholar]
  31. McKiel JA, West AS, , 1961. Nature and causation of insect bites reactions. Pediatr Clin North Am 8: 795815.[Crossref] [Google Scholar]
  32. Brummer-Korvenkontio HL, Reunala P, Palosuo T, , 1994. Detection of mosquito saliva-specific IgE and IgG4 antibodies by immunoblotting. Allergy and Clinical Immunology 93: 551555.[Crossref] [Google Scholar]
  33. Clements M, Gidwani K, Kumar R, Hostomska J, Dinesh D, Kumar V, Das P, Muller I, Hamilton G, Volfova V, Boelaert M, Das M, Rijal S, Picado A, Volf P, Sundar S, Davies C, Rogers M, , 2010. Measurement of recent exposure to Phlebotomus argentipes, the vector of Indian visceral leishmaniasis, by using human antibody responses to sand fly saliva. Am J Trop Med Hyg 82: 801807.[Crossref] [Google Scholar]
  34. Poinsignon A, Cornelie S, Ba F, Boulanger D, Sow C, Rossignol M, Sokhna C, Cisse B, Simondon F, Remoue F, , 2009. Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites. Malar J 8: 198.[Crossref] [Google Scholar]
  35. Peng Z, Li H, Simons FE, , 1998. Immunoblot analysis of salivary allergens in 10 mosquito species with worldwide distribution and the human IgE responses to these allergens. J Allergy Clin Immunol 101: 498505.[Crossref] [Google Scholar]
  36. Choumet V, Carmi-Leroy A, Laurent C, Lenormand P, Rousselle JC, Namane A, Roth C, Brey PT, , 2007. The salivary glands and saliva of Anopheles gambiae as an essential step in the Plasmodium life cycle: a global proteomic study. Proteomics 7: 33843394.[Crossref] [Google Scholar]
  37. Poinsignon A, Cornelie S, Mestres-Simon M, Lanfrancotti A, Rossignol M, Boulanger D, Cisse B, Sokhna C, Arca B, Simondon F, Remoue F, , 2008. Novel peptide marker corresponding to salivary protein gSG6 potentially identifies exposure to Anopheles bites. PLoS ONE 3: e2472.[Crossref] [Google Scholar]
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  • Received : 22 Jul 2011
  • Accepted : 15 Apr 2012

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