Volume 86, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The efficacy of a single oral dose of 30 mg/kg of oxfendazole against was evaluated in a controlled study in naturally infected sheep. Sheep were diagnosed by stool microscopy after sedimentation, and positive animals were randomized to oxfendazole ( = 20) or no treatment ( = 20). A new stool exam was performed 10 days after treatment. All stool microscopies were performed masked to the treatment group. No side effects were noticed. All sheep in the control group remained infected with similar counts of eggs per gram of stools. None of the animals in the treatment group showed eggs in stools after 10 days of treatment. A single dose of oxfendazole is highly effective against , providing a new drug alternative for the control of fascioliasis or integrated zoonosis control.


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  1. Mas-Coma S, Valero MA, Bargues MD, , 2009. Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. Adv Parasitol 69: 41146.[Crossref]
  2. Lean I, Westwood C, Playford M, , 2008. Livestock disease threats associated with intensification of pastoral dairy farming. N Z Vet J 56: 261269.[Crossref]
  3. Parkinson M, O’Neill SM, Dalton JP, , 2007. Endemic human fasciolosis in the Bolivian Altiplano. Epidemiol Infect 135: 669674.[Crossref]
  4. Marcos LA, Terashima A, Leguia G, Canales M, Espinoza JR, Gotuzzo E, , 2007. Fasciola hepatica infection in Peru: an emergent disease. Rev Gastroenterol Peru 27: 389396.
  5. Espinoza JR, Terashima A, Herrera-Velit P, Marcos LA, , 2010. Human and animal fascioliasis in Peru: impact in the economy of endemic zones. Rev Peru Med Exp Salud Publica 27: 604612.[Crossref]
  6. Keiser J, Duthaler U, Utzinger J, , 2010. Update on the diagnosis and treatment of food-borne trematode infections. Curr Opin Infect Dis 23: 513520.[Crossref]
  7. Fairweather I, , 2009. Triclabendazole progress report, 2005–2009: an advancement of learning? J Helminthol 83: 139150.[Crossref]
  8. Brennan GP, Fairweather I, Trudgett A, Hoey E, McCoy McConville M, Meaney M, Robinson M, McFerran N, Ryan L, Lanusse C, Mottier L, Alvarez L, Solana H, Virkel G, Brophy PM, , 2007. Understanding triclabendazole resistance. Exp Mol Pathol 82: 104109.[Crossref]
  9. Alvarez-Sanchez MA, Mainar-Jaime RC, Perez-Garcia J, Rojo-Vazquez FA, , 2006. Resistance of Fasciola hepatica to triclabendazole and albendazole in sheep in Spain. Vet Rec 159: 424425.[Crossref]
  10. Overend DJ, Bowen FL, , 1995. Resistance of Fasciola hepatica to triclabendazole. Aust Vet J 72: 275276.[Crossref]
  11. Olaechea F, Lovera V, Larroza M, Raffo F, Cabrera R, , 2011. Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina). Vet Parasitol 178: 364366.[Crossref]
  12. Oliveira DR, Ferreira DM, Stival CC, Romero F, Cavagnolli F, Kloss A, Araujo FB, Molento MB, , 2008. Triclabendazole resistance involving Fasciola hepatica in sheep and goats during an outbreak in Almirante Tamandare, Parana, Brazil. Rev Bras Parasitol Vet 17 17 (Suppl 1): 149153.
  13. Rojas M, , 1990. Parasitismo de los Rumiantes Domésticos. Lima, Peru: Maijosa.
  14. Snedecor GW, Cochran WG, , 1989. Statistical Methods. Ames, IA: Iowa State University Press.
  15. Gavidia CM, Gonzalez AE, Barron EA, Ninaquispe B, Llamosas M, Verastegui MR, Robinson C, Gilman RH, , 2010. Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. PLoS Negl Trop Dis 4: e616.[Crossref]
  16. Gonzalez AE, Gavidia C, Falcon N, Bernal T, Verastegui M, Garcia HH, Gilman RH, Tsang VC, , 2001. Protection of pigs with cysticercosis from further infections after treatment with oxfendazole. Am J Trop Med Hyg 65: 1518.
  17. Alvarez L, Moreno G, Moreno L, Ceballos L, Shaw L, Fairweather I, Lanusse C, , 2009. Comparative assessment of albendazole and triclabendazole ovicidal activity on Fasciola hepatica eggs. Vet Parasitol 164: 211216.[Crossref]
  18. McKellar QA, Scott EW, , 1990. The benzimidazole anthelmintic agents–a review. J Vet Pharmacol Ther 13: 223247.[Crossref]
  19. Bogan J, Armour J, , 1987. Anthelmintics for ruminants. Int J Parasitol 17: 483491.[Crossref]
  20. Boray JC, Crowfoot PD, Strong MB, Allison JR, Schellenbaum M, Von Orelli M, Sarasin G, , 1983. Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole. Vet Rec 113: 315317.[Crossref]
  21. Fairweather I, , 2005. Triclabendazole: new skills to unravel an old(ish) enigma. J Helminthol 79: 227234.[Crossref]
  22. Keiser J, Engels D, Buscher G, Utzinger J, , 2005. Triclabendazole for the treatment of fascioliasis and paragonimiasis. Expert Opin Investig Drugs 14: 15131526.[Crossref]
  23. Keiser J, Utzinger J, , 2004. Chemotherapy for major food-borne trematodes: a review. Expert Opin Pharmacother 5: 17111726.[Crossref]
  24. Fairweather I, , 2011. Raising the bar on reporting ‘triclabendazole resistance’. Vet Rec 168: 514515.[Crossref]
  25. Fraser DE, Hunt PJ, Skinner RJ, Coles GC, , 2006. Survey of parasite control on sheep farms in south-west England. Vet Rec 158: 5557.[Crossref]
  26. Furmaga S, Gundalach JL, Sadzikowski A, , Paciejewski S, 1982. (Systamex (oxfendazole) in the treatment of parasitoses of sheep). Med Weter 38: 269271.
  27. Lanusse CE, Gascon LH, Prichard RK, , 1995. Comparative plasma disposition kinetics of albendazole, fenbendazole, oxfendazole and their metabolites in adult sheep. J Vet Pharmacol Ther 18: 196203.[Crossref]
  28. Soraci AL, Mestorino N, Errecalde JO, , 1997. Some pharmacokinetic parameters of oxfendazole in sheep. Vet Res Commun 21: 283287.[Crossref]
  29. Blanton RE, Wachira TM, Zeyhle EE, Njoroge EM, Magambo JK, Schantz PM, , 1998. Oxfendazole treatment for cystic hydatid disease in naturally infected animals. Antimicrob Agents Chemother 42: 601605.

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  • Received : 21 Jul 2011
  • Accepted : 24 Sep 2011

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