1921
Volume 86, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The efficacy of a single oral dose of 30 mg/kg of oxfendazole against was evaluated in a controlled study in naturally infected sheep. Sheep were diagnosed by stool microscopy after sedimentation, and positive animals were randomized to oxfendazole ( = 20) or no treatment ( = 20). A new stool exam was performed 10 days after treatment. All stool microscopies were performed masked to the treatment group. No side effects were noticed. All sheep in the control group remained infected with similar counts of eggs per gram of stools. None of the animals in the treatment group showed eggs in stools after 10 days of treatment. A single dose of oxfendazole is highly effective against , providing a new drug alternative for the control of fascioliasis or integrated zoonosis control.

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References

  1. Mas-Coma S, Valero MA, Bargues MD, , 2009. Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. Adv Parasitol 69: 41146.[Crossref] [Google Scholar]
  2. Lean I, Westwood C, Playford M, , 2008. Livestock disease threats associated with intensification of pastoral dairy farming. N Z Vet J 56: 261269.[Crossref] [Google Scholar]
  3. Parkinson M, O’Neill SM, Dalton JP, , 2007. Endemic human fasciolosis in the Bolivian Altiplano. Epidemiol Infect 135: 669674.[Crossref] [Google Scholar]
  4. Marcos LA, Terashima A, Leguia G, Canales M, Espinoza JR, Gotuzzo E, , 2007. Fasciola hepatica infection in Peru: an emergent disease. Rev Gastroenterol Peru 27: 389396. [Google Scholar]
  5. Espinoza JR, Terashima A, Herrera-Velit P, Marcos LA, , 2010. Human and animal fascioliasis in Peru: impact in the economy of endemic zones. Rev Peru Med Exp Salud Publica 27: 604612.[Crossref] [Google Scholar]
  6. Keiser J, Duthaler U, Utzinger J, , 2010. Update on the diagnosis and treatment of food-borne trematode infections. Curr Opin Infect Dis 23: 513520.[Crossref] [Google Scholar]
  7. Fairweather I, , 2009. Triclabendazole progress report, 2005–2009: an advancement of learning? J Helminthol 83: 139150.[Crossref] [Google Scholar]
  8. Brennan GP, Fairweather I, Trudgett A, Hoey E, McCoy McConville M, Meaney M, Robinson M, McFerran N, Ryan L, Lanusse C, Mottier L, Alvarez L, Solana H, Virkel G, Brophy PM, , 2007. Understanding triclabendazole resistance. Exp Mol Pathol 82: 104109.[Crossref] [Google Scholar]
  9. Alvarez-Sanchez MA, Mainar-Jaime RC, Perez-Garcia J, Rojo-Vazquez FA, , 2006. Resistance of Fasciola hepatica to triclabendazole and albendazole in sheep in Spain. Vet Rec 159: 424425.[Crossref] [Google Scholar]
  10. Overend DJ, Bowen FL, , 1995. Resistance of Fasciola hepatica to triclabendazole. Aust Vet J 72: 275276.[Crossref] [Google Scholar]
  11. Olaechea F, Lovera V, Larroza M, Raffo F, Cabrera R, , 2011. Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina). Vet Parasitol 178: 364366.[Crossref] [Google Scholar]
  12. Oliveira DR, Ferreira DM, Stival CC, Romero F, Cavagnolli F, Kloss A, Araujo FB, Molento MB, , 2008. Triclabendazole resistance involving Fasciola hepatica in sheep and goats during an outbreak in Almirante Tamandare, Parana, Brazil. Rev Bras Parasitol Vet 17 17 (Suppl 1): 149153. [Google Scholar]
  13. Rojas M, , 1990. Parasitismo de los Rumiantes Domésticos. Lima, Peru: Maijosa. [Google Scholar]
  14. Snedecor GW, Cochran WG, , 1989. Statistical Methods. Ames, IA: Iowa State University Press. [Google Scholar]
  15. Gavidia CM, Gonzalez AE, Barron EA, Ninaquispe B, Llamosas M, Verastegui MR, Robinson C, Gilman RH, , 2010. Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. PLoS Negl Trop Dis 4: e616.[Crossref] [Google Scholar]
  16. Gonzalez AE, Gavidia C, Falcon N, Bernal T, Verastegui M, Garcia HH, Gilman RH, Tsang VC, , 2001. Protection of pigs with cysticercosis from further infections after treatment with oxfendazole. Am J Trop Med Hyg 65: 1518. [Google Scholar]
  17. Alvarez L, Moreno G, Moreno L, Ceballos L, Shaw L, Fairweather I, Lanusse C, , 2009. Comparative assessment of albendazole and triclabendazole ovicidal activity on Fasciola hepatica eggs. Vet Parasitol 164: 211216.[Crossref] [Google Scholar]
  18. McKellar QA, Scott EW, , 1990. The benzimidazole anthelmintic agents–a review. J Vet Pharmacol Ther 13: 223247.[Crossref] [Google Scholar]
  19. Bogan J, Armour J, , 1987. Anthelmintics for ruminants. Int J Parasitol 17: 483491.[Crossref] [Google Scholar]
  20. Boray JC, Crowfoot PD, Strong MB, Allison JR, Schellenbaum M, Von Orelli M, Sarasin G, , 1983. Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole. Vet Rec 113: 315317.[Crossref] [Google Scholar]
  21. Fairweather I, , 2005. Triclabendazole: new skills to unravel an old(ish) enigma. J Helminthol 79: 227234.[Crossref] [Google Scholar]
  22. Keiser J, Engels D, Buscher G, Utzinger J, , 2005. Triclabendazole for the treatment of fascioliasis and paragonimiasis. Expert Opin Investig Drugs 14: 15131526.[Crossref] [Google Scholar]
  23. Keiser J, Utzinger J, , 2004. Chemotherapy for major food-borne trematodes: a review. Expert Opin Pharmacother 5: 17111726.[Crossref] [Google Scholar]
  24. Fairweather I, , 2011. Raising the bar on reporting ‘triclabendazole resistance’. Vet Rec 168: 514515.[Crossref] [Google Scholar]
  25. Fraser DE, Hunt PJ, Skinner RJ, Coles GC, , 2006. Survey of parasite control on sheep farms in south-west England. Vet Rec 158: 5557.[Crossref] [Google Scholar]
  26. Furmaga S, Gundalach JL, Sadzikowski A, , Paciejewski S, 1982. (Systamex (oxfendazole) in the treatment of parasitoses of sheep). Med Weter 38: 269271. [Google Scholar]
  27. Lanusse CE, Gascon LH, Prichard RK, , 1995. Comparative plasma disposition kinetics of albendazole, fenbendazole, oxfendazole and their metabolites in adult sheep. J Vet Pharmacol Ther 18: 196203.[Crossref] [Google Scholar]
  28. Soraci AL, Mestorino N, Errecalde JO, , 1997. Some pharmacokinetic parameters of oxfendazole in sheep. Vet Res Commun 21: 283287.[Crossref] [Google Scholar]
  29. Blanton RE, Wachira TM, Zeyhle EE, Njoroge EM, Magambo JK, Schantz PM, , 1998. Oxfendazole treatment for cystic hydatid disease in naturally infected animals. Antimicrob Agents Chemother 42: 601605. [Google Scholar]
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  • Received : 21 Jul 2011
  • Accepted : 24 Sep 2011

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