1921
Volume 87, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Four terpenoid derivatives were examined for their activity against Our results show that two compounds were very active against both extra- and intracellular forms. These compounds, non-toxic for the host cells, are more effective than the reference drug benznidazole. The capacity to infect cells was negatively affected and the number of amastigotes and trypomastigotes was reduced. A wide range of ultrastructural alterations was found in the epimastigote forms treated with these compounds. Some metabolic changes occurred presumably at the level of succinate and acetate production, perhaps caused by the disturbance of the enzymes involved in sugar metabolism inside the mitochondria. results were consistent with those observed . The parasitic load was significantly lower than in the control assay with benznidazole. The effects of these products showed the reduction of the anti- antibodies level during the chronic stage.

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  • Received : 20 Jul 2011
  • Accepted : 26 Nov 2011
  • Published online : 05 Sep 2012

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