Volume 86, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Neurobrucellosis is an uncommon complication of pediatric brucellosis. Acute meningitis and encephalitis are the most common clinical manifestations, however symptoms may be protean and diagnosis requires a high index of suspicion in patients from endemic areas. Diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal fluid culture yields are low. Two cases of pediatric neurobrucellosis with unusual clinical and radiologic findings are presented.


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  1. Gottesman G, Vanunu D, Maayan MC, Lang R, Uziel Y, Sagi H, Wolach B, , 1996. Childhood brucellosis in Israel. Pediatr Infect Dis J 15: 610615.[Crossref] [Google Scholar]
  2. Omar FZ, Zuberi S, Minns RA, , 1997. Neurobrucellosis in childhood: six new cases and a review of the literature. Dev Med Child Neurol 39: 762765.[Crossref] [Google Scholar]
  3. Mantur BG, Akki AS, Mangalgi SS, Patil SV, Gobbur RH, Peerapur BV, , 2004. Childhood brucellosis–a microbiological, epidemiological and clinical study. J Trop Pediatr 50: 153157.[Crossref] [Google Scholar]
  4. Colmenero JD, Reguera JM, Martos F, Sanchez-De-Mora D, Delgado M, Causse M, Martin-Farfan A, Juarez C, , 1996. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 75: 195211.[Crossref] [Google Scholar]
  5. Lubani MM, Dudin KI, Araj GF, Manandhar DS, Rashid FY, , 1989. Neurobrucellosis in children. Pediatr Infect Dis J 8: 7982.[Crossref] [Google Scholar]
  6. Habeeb YK, Al-Najdi AK, Sadek SA, Al-Onaizi E, , 1998. Pediatric neurobrucellosis: case report and literature review. J Infect 37: 5962.[Crossref] [Google Scholar]
  7. Shakir RA, Al-Din AS, Araj GF, Lulu AR, Mousa AR, Saadah MA, , 1987. Clinical categories of neurobrucellosis. A report on 19 cases. Brain 110: 213223.[Crossref] [Google Scholar]
  8. Romero C, Gamazo C, Pardo M, Lopez-Goni I, , 1995. Specific detection of Brucella DNA by PCR. J Clin Microbiol 33: 615617. [Google Scholar]
  9. Araj GF, , 2010. Update on laboratory diagnosis of human brucellosis. Int J Antimicrob Agents 36: (Suppl 1) S12S17.[Crossref] [Google Scholar]
  10. Bouza E, Garcia de la Torre M, Parras F, Guerrero A, Rodriguez-Creixems M, Gobernado J, , 1987. Brucellar meningitis. Rev Infect Dis 9: 810822.[Crossref] [Google Scholar]
  11. Pascual J, Combarros O, Polo JM, Berciano J, , 1988. Localized CNS brucellosis: report of 7 cases. Acta Neurol Scand 78: 282289.[Crossref] [Google Scholar]
  12. Colmenero JD, Queipo-Ortuno MI, Reguera JM, Baeza G, Salazar JA, Morata P, , 2005. Real time polymerase chain reaction: a new powerful tool for the diagnosis of neurobrucellosis. J Neurol Neurosurg Psychiatry 76: 10251027.[Crossref] [Google Scholar]
  13. Miguel PS, Fernandez G, Vasallo FJ, Hortas M, Lorenzo JR, Rodriguez I, Ortiz-Rey JA, Anton I, , 2006. Neurobrucellosis mimicking cerebral tumor: case report and literature review. Clin Neurol Neurosurg 108: 404406.[Crossref] [Google Scholar]
  14. American Academy of Pediatrics Pickering LK, Baker CJ, Kimberlin DW, Long SS, , 2009. Brucellosis. , eds. Red Book: 2009 Report of the Committee of Infectious Diseases. 28th edition. Elk Grove Village, IL: American Academy of Pediatrics, 237239. [Google Scholar]

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  • Received : 19 Jul 2011
  • Accepted : 30 Aug 2011
  • Published online : 01 Feb 2012

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