1921
Volume 86, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Little information is available on transplacental transmission of spp. We determined the frequency and impact of congenital infection caused by or . in experimentally infected hamsters. A polymerase chain reaction showed that congenital transmission occurred in 25.8% (24 of 93) of offspring born to . -infected hamsters and 14.6% (11 of 75) offspring born to -infected hamsters. Mortality during lactation was higher in offspring born to . -infected hamsters and offspring born to -infected hamsters than controls, and lymphoproliferation to was more frequent in offspring born to . -infected hamsters (17.4%, 11 of 63) than in offspring born to -infected hamsters (8.5%, 3 of 35). After weaning, only offspring born to -infected hamsters had lower weight gain ( < 0.001) and hematocrit levels ( = 0.0045) than controls. Challenge of offspring born to . -infected hamsters with showed no differences in lesion evolution, and offspring born to -infected hamsters were more susceptible to challenge than controls. Consequently, prenatal exposure of hamsters to significantly increased the mortality risk and susceptibility to secondary homologous infection.

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  • Received : 14 Jul 2011
  • Accepted : 02 Jan 2012

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