1921
Volume 86, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

There is a high prevalence of fascioliasis in the Peruvian highlands, but most cases remain undiagnosed. The burden of disease caused by chronic subclinical infection is largely unknown. We studied school-age children from a district in Paucartambo Province in Cusco, Peru to evaluate the burden of disease caused by subclinical fascioliasis. Parasite eggs and/or larvae were identified in 46.2% of subjects, including in 10.3% of subjects. Fascioliasis was independently associated with anemia (adjusted odds ratio = 3.01 [1.10–8.23]). Subclinical fascioliasis was common among children and strongly associated with anemia. Anemia should be recognized as an important component of the burden of disease from fascioliasis.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2012.11-0448
2012-03-01
2017-11-24
Loading full text...

Full text loading...

/deliver/fulltext/14761645/86/3/481.html?itemId=/content/journals/10.4269/ajtmh.2012.11-0448&mimeType=html&fmt=ahah

References

  1. World Health Organization, 2009. Fascioliasis: infection with the “neglected” neglected worms. Available at: http://www.who.int/neglected_diseases/integrated_media/integrated_media_fascioliasis/en/index.html. Accessed June 4, 2011.
  2. Mas-Coma S, Valero MA, Bargues MD, , 2009. Chapter 2: Fasciola, lymnaeids, and human fascioliasis, with a global overview of disease transmission, epidemiology, evolutionary genetics, molecular epidemiology, and control. Adv Parasitol 69: 41146.[Crossref]
  3. Mas-Coma MS, Esteban JG, Bargues MD, , 1999. Epidemiology of human fascioliasis: a review and proposed new classification. Bull World Health Organ 77: 340346.
  4. Marcos LA, Tagle M, Terashima A, Bussalleu A, Ramirez C, Carrasco C, Valdez L, Huerta-Mercado J, Freedman DO, Vinetz JM, Gotuzzo E, , 2008. Natural history, clinicoradiologic correlates, and response to triclabendazole in acute massive fascioliasis. Am J Trop Med Hyg 78: 222227.
  5. Blancas G, Terashima A, Maguina C, Vera L, Alvarez H, Tello R, , 2004. Human fascioliasis and gastrointestinal involvement: review of 277 cases seen between 1970 and 2002 at Hospital Nacional Cayetano Heredia. Rev Gastroenterol Peru 24: 143157.
  6. Marcos LA, Maco V, Castillo M, Terashima A, Zerpa R, Gotuzzo E, , 2005. Case series of fascioliasis seen between 1988 and 2003 at Instituto Especializado de Salud del Niño, Lima-Peru. Rev Gastroenterol Peru 25: 198205.
  7. Marcos LA, Terashima A, Leguia G, Canales M, Espinoza JR, Gotuzzo E, , 2007. Fasciola hepatica infection in Peru: an emerging disease. Rev Gastroenterol Peru 27: 389396.
  8. Marcos LA, Maco V, Terashima A, Samalvides F, Gotuzzo E, , 2002. Clinical characteristics of Fasciola hepatica infection in children. Rev Gastroenterol Peru 22: 228233.
  9. Madan N, Rusia U, Sikka M, Sharma S, Shankar N, , 2011. Developmental and neurophysiologic deficits in iron deficiency children. Indian J Pediatr 78: 5864.[Crossref]
  10. Marcos LA, Yi P, Machicado A, Andrade R, Samalvides F, Sanchez J, Terashima A, , 2007. Hepatic fibrosis and Fasciola hepatica infection in cattle. J Helminthol 81: 381386.[Crossref]
  11. Marcos LA, Bussalleu A, Terashima A, Espinoza JR, , 2009. Detection of antibodies against Fasciola hepatica in cirrhotic patients from Peru. Helminthol 83: 2326.[Crossref]
  12. Maco-Flores V, Marcos-Raymundo L, Terashima-Iwashita A, Samalvides-Cuba F, Miranda-Sanchez E, Espinoza-Babilon J, Gotuzzo-Herencia E, , 2002. Fas-2 ELISA and the rapid sedimentation technique modified by Lumbreras for Fasciola hepatica infection diagnosis. Rev Med Hered 13: 4957.[Crossref]
  13. Terashima A, Marcos L, Maco V, Canales M, Samalvides F, Tello R, , 2009. Highly sensitive in test tube sedimentation technique for the diagnosis of intestinal parasites. Rev Gastroenterol Peru 29: 305310.
  14. Nestel P, , 2002. Adjusting Hemoglobin Values in Program Surveys. For the International Nutritional Anemia Consultative Group. Available at: http://pdf.usaid.gov/pdf_docs/PNACQ927.pdf. Accessed June 2, 2011.
  15. Dirren H, Logman MH, Barclay DV, Freire WB, , 1994. Altitude correction for hemoglobin. Eur J Clin Nutr 48: 625632.
  16. World Health Organization, 2001. Iron Deficiency Anaemia Assessment, Prevention and Control: A Guide for Programme Managers. Available at: http://www.who.int/nutrition/publications/en/ida_assessment_prevention_control.pdf. Accessed June 4, 2011.
  17. De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J, , 2007. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85: 660667.[Crossref]
  18. World Health Organization, 2011. Application Tools: WHO AnthroPlus Manual. Available at: http://www.who.int/growthref/tools/en/. Accessed June 4, 2011.
  19. Zevallos K, Vergara KC, Vergara A, Vidal C, Garcia HH, Evans CA, , 2010. Tuberculin skin-test reactions are unaffected by the severity of hyperendemic intestinal helminth infections and co-infections. Am J Trop Med Hyg 83: 319325.[Crossref]
  20. Maco-Flores V, Marcos-Raymundo LA, Terashima-Iwashita A, Samalvides-Cuba F, Gotuzzo-Herencia E, , 2002. Distribution of enteric parasites in the Peruvian Altiplano: a study in 6 communities in Puno, Peru. Rev Gastroenterol Peru 22: 304309.
  21. Cabrera M, Verastegui M, Cabrera R, , 2005. Prevalence of enteric parasites in a highland community of the Victor Fajardo Province, Ayacucho, Peru. Rev Gastroenterol Peru 25: 150155.
  22. INEI, 2010. Peruvian Poverty Map by Province and District 2009: Focused on Income. Available at: http://www.unfpa.org.pe/publicaciones/publicacionesperu/INEI-Mapa-Pobreza-2009. Accessed June 4, 2011.
  23. Ngui R, Ishak S, Chuen CS, Mahmud R, Lim YA, , 2011. Prevalence and risk factors of intestinal parasitism in rural and remote west Malaysia. PLoS Negl Trop Dis 5: e974.[Crossref]
  24. Quihui I, Valencia ME, Cromptom DW, Phillips S, Hagan P, Morales G, Diaz-Camacho SP, , 2006. Role of the employment status and education of mothers in the prevalence of intestinal parasitic infections in Mexican rural schoolchildren. BMC Public Health 6: 225.[Crossref]
  25. Marcos LA, Terashima A, Gotuzzo E, , 2008. Update on hepatobiliary flukes: fascioliasis, opisthorchiasis, and clonorchiasis. Curr Opin Infect Dis 21: 523530.[Crossref]
  26. Mas-Coma S, Angles R, Esteban JG, Bargues MD, Buchon P, Franken M, Strauss W, , 1999. The northern Bolivian Altiplano: a region highly endemic for human fascioliasis. Trop Med Int Health 4: 454467.[Crossref]
  27. Marcos L, Romani L, Florencio L, Terashima A, Canales M, Nestares J, Huayanay L, Gotuzzo E, , 2007. Hyperendemic and mesoendemic areas for Fasciola hepatica infection near Lima: an emerging illness? Rev Gastroenterol Peru 27: 2126.
  28. Parkinson M, O'Neill SM, Dalton JP, , 2007. Endemic human fascioliosis in the Bolivian Altiplano. Epidemiol Infect 135: 669674.[Crossref]
  29. Marcos L, Maco V, Samalvides F, Terashima A, Espinoza JR, Gotuzzo E, , 2006. Risk factors for Fasciola hepatica infection in children: a case-control study. Trans R Soc Trop Med Hyg 100: 158166.[Crossref]
  30. Mas-Coma S, Funatsu IR, Bargues MD, , 2001. Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America. Parasitology 123: S115S127.[Crossref]
  31. Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B, ; International Child Development Steering Group, 2007. Child development in developing countries 1: developmental potential in the first 5 years for children in developing countries. Lancet 369: 6070.[Crossref]
  32. Gyorkos TW, Maheu-Giroux M, Casapia M, Joseph SA, Creed-Kanashiro H, , 2011. Stunting and helminths infection in early preschool-age children in a resource-poor community in the Amazon lowlands of Peru. Trans R Soc Trop Med Hyg 105: 204208.[Crossref]
  33. Casapia M, Joseph SA, Nunez C, Rahme E, Gyorkos TW, , 2006. Parasite risk factors for stunting in grade 5 students in a community of extreme poverty in Peru. Int J Parasitol 36: 741747.[Crossref]
  34. King CH, , 2010. Health metrics for helminth infections. Adv Parasitol 73: 5169.[Crossref]
  35. El-Shazly AM, El-Nahas HA, Abdel-Mageed AA, El Beshbishi SN, Azab MS, El Hasan MA, Arafa WA, Morsy TA, , 2005. Human fascioliasis and aneamia in Dakahlia governorate, Egypt. J Egypt Soc Parasitol 35: 421432.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2012.11-0448
Loading
/content/journals/10.4269/ajtmh.2012.11-0448
Loading

Data & Media loading...

  • Received : 12 Jul 2011
  • Accepted : 01 Oct 2011

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error