1921
Volume 86, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects ( = 27), mean [SD] parameters were C: 58.9 [12.5] ng/mL; t: 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [1,328] ng/h/mL; Vλ/F: 2,829 [1,267] L; CL/F: 2.76 [1.28] L/h; and t: 784 [347] h. Compared with fasted subjects, fed subjects ( = 27) exhibited a 34% increase in C, delay in t to 5.3 [2.1] h, 44% increase in AUC, 40% decrease in Vλ/F, and a 35% decrease in CL/F. There was no significant change in t. The changes are consistent with an increase in moxidectin bioavailability following administration with food. There were no clinically relevant changes in vital signs, laboratory tests, or electrocardiograms.

[open-access] Freely available online through the Open Access option.

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2017-09-23
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  • Received : 28 Jun 2011
  • Accepted : 09 Sep 2011

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