1921
Volume 86, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The agents of human febrile illness can vary by region and country suggesting that diagnosis, treatment, and control programs need to be based on a methodical evaluation of area-specific etiologies. From December 2006 to December 2009, 9,997 individuals presenting with acute febrile illness at nine health care clinics in south-central Cambodia were enrolled in a study to elucidate the etiologies. Upon enrollment, respiratory specimens, whole blood, and serum were collected. Testing was performed for viral, bacterial, and parasitic pathogens. Etiologies were identified in 38.0% of patients. Influenza was the most frequent pathogen, followed by dengue, malaria, and bacterial pathogens isolated from blood culture. In addition, 3.5% of enrolled patients were infected with more than one pathogen. Our data provide the first systematic assessment of the etiologies of acute febrile illness in south-central Cambodia. Data from syndromic-based surveillance studies can help guide public health responses in developing nations.

[open-access] Freely available online through the Open Access option.

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2012-02-01
2017-09-24
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References

  1. Jelinek T, Muhlberger N, Harms G, Corachan M, Grobusch MP, Knobloch J, Bronner U, Laferl H, Kapaun A, Bisoffi Z, Clerinx J, Puente S, Fry G, Schulze M, Hellgren U, Gjorup I, Chalupa P, Hatz C, Matteelli A, Schmid M, Nielsen LN, da Cunha S, Atouguia J, Myrvang B, Fleischer K, , 2002. Epidemiology and clinical features of imported dengue fever in Europe: sentinel surveillance data from TropNetEurop. Clin Infect Dis 35: 10471052.[Crossref]
  2. Jelinek T, Peyerl-Hoffmann G, Muhlberger N, Wichmann O, Wilhelm M, Schmider N, Grobusch MP, von Sonnenburg F, Gascon J, Laferl H, Hatz C, Alifrangis M, Burchard G, McWhinney P, Schulze M, Kollaritsch H, da Cunha S, Beran J, Kern P, Gjorup I, Cuadros J, , 2002. Molecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in Europe. Malar J 1: 11.[Crossref]
  3. Tabak F, Mert A, Celik AD, Ozaras R, Altiparmak MR, Ozturk R, Aktuglu Y, , 2003. Fever of unknown origin in Turkey. Infection 31: 417420.
  4. Zhiyong Z, Bingjun L, Xiaoju L, Xinjian F, Ping F, Wenya W, , 2003. Fever of unknown origin: a report from China of 208 cases. Int J Clin Pract 57: 592596.
  5. Leelarasamee A, Chupaprawan C, Chenchittikul M, Udompanthurat S, , 2004. Etiologies of acute undifferentiated febrile illness in Thailand. J Med Assoc Thai 87: 464472.
  6. Manock SR, Jacobsen KH, de Bravo NB, Russell KL, Negrete M, Olson JG, Sanchez JL, Blair PJ, Smalligan RD, Quist BK, Espin JF, Espinoza WR, MacCormick F, Fleming LC, Kochel T, , 2009. Etiology of acute undifferentiated febrile illness in the Amazon basin of Ecuador. Am J Trop Med Hyg 81: 146151.
  7. Arthur JD, Bodhidatta L, Echeverria P, Phuphaisan S, Paul S, , 1992. Diarrheal disease in Cambodian children at a camp in Thailand. Am J Epidemiol 135: 541551.[Crossref]
  8. Sutherland JE, Avant RF, Franz WB, 3rd Monzon CM, Stark NM, , 1983. Indochinese refugee health assessment and treatment. J Fam Pract 16: 6167.
  9. Srey VH, Sadones H, Ong S, Mam M, Yim C, Sor S, Grosjean P, Reynes JM, Grosjean P, Reynes JM, , 2002. Etiology of encephalitis syndrome among hospitalized children and adults in Takeo, Cambodia, 1999–2000. Am J Trop Med Hyg 66: 200207.
  10. Chhour YM, Ruble G, Hong R, Minn K, Kdan Y, Sok T, Nisalak A, Myint KS, Vaughn DW, Endy TP, , 2002. Hospital-based diagnosis of hemorrhagic fever, encephalitis, and hepatitis in Cambodian children. Emerg Infect Dis 8: 485489.[Crossref]
  11. Boivin G, Hardy I, Tellier G, Maziade J, , 2000. Predicting influenza infections during epidemics with use of a clinical case definition. Clin Infect Dis 31: 11661169.[Crossref]
  12. Navarro-Mari JM, Perez-Ruiz M, Cantudo-Munoz P, Petit-Gancedo C, Jimenez-Valera M, Rosa-Fraile M, , 2005. Influenza-like illness criteria were poorly related to laboratory-confirmed influenza in a sentinel surveillance study. J Clin Epidemiol 58: 275279.[Crossref]
  13. Nicholson KG, , 1992. Clinical features of influenza. Semin Respir Infect 7: 2637.
  14. Porter KR, Tan R, Istary Y, Suharyono W, Sutaryo Widjaja S, Ma’Roef C, Listiyaningsih E, Kosasih H, Hueston L, McArdle J, Juffrie M, , 2004. A serological study of Chikungunya virus transmission in Yogyakarta, Indonesia: evidence for the first outbreak since 1982. Southeast Asian J Trop Med Public Health 35: 408415.
  15. Graf PC, Chretien JP, Ung L, Gaydos JC, Richards AL, , 2008. Prevalence of seropositivity to spotted fever group rickettsiae and Anaplasma phagocytophilum in a large, demographically diverse US sample. Clin Infect Dis 46: 7077.[Crossref]
  16. Richards AL, Soeatmadji DW, Widodo MA, Sardjono TW, Yanuwiadi B, Hernowati TE, Baskoro AD, Roebiyoso Hakim L, Soendoro M, Rahardjo E, Putri MP, Saragih JM, Strickman D, Kelly DJ, Dasch GA, Olson JG, Church CJ, Corwin AL, , 1997. Seroepidemiologic evidence for murine and scrub typhus in Malang, Indonesia. Am J Trop Med Hyg 57: 9195.
  17. Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV, , 1992. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30: 545551.
  18. Reynes JM, Ong S, Mey C, Ngan C, Hoyer S, Sall AA, , 2003. Improved molecular detection of dengue virus serotype 1 variants. J Clin Microbiol 41: 38643867.[Crossref]
  19. Henry KM, Jiang J, Rozmajzl PJ, Azad AF, Macaluso KR, Richards AL, , 2007. Development of quantitative real-time PCR assays to detect Rickettsia typhi and Rickettsia felis, the causative agents of murine typhus and flea-borne spotted fever. Mol Cell Probes 21: 1723.[Crossref]
  20. Jiang J, Chan TC, Temenak JJ, Dasch GA, Ching WM, Richards AL, , 2004. Development of a quantitative real-time polymerase chain reaction assay specific for Orientia tsutsugamushi . Am J Trop Med Hyg 70: 351356.
  21. Aitichou M, Saleh SS, McElroy AK, Schmaljohn C, Ibrahim MS, , 2005. Identification of Dobrava, Hantaan, Seoul, and Puumala viruses by one-step real-time RT-PCR. J Virol Methods 124: 2126.[Crossref]
  22. Seriwatana J, Shrestha MP, Scott RM, Tsarev SA, Vaughn DW, Myint KS, Innis BL, , 2002. Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M. Clin Diagn Lab Immunol 9: 10721078.
  23. Blair PJ, Wierzba TF, Touch S, Vonthanak S, Xu X, Garten RJ, Okomo-Adhiambo MA, Klimov AI, Kasper MR, Putnam SD, , 2010. Influenza epidemiology and characterization of influenza viruses in patients seeking treatment for acute fever in Cambodia. Epidemiol Infect 138: 199209.[Crossref]
  24. Ol HS, Bjoerkvoll B, Sothy S, Van Heng Y, Hoel H, Husebekk A, Gutteberg T, Larsen S, Husum H, , 2009. Prevalence of hepatitis B and hepatitis C virus infections in potential blood donors in rural Cambodia. Southeast Asian J Trop Med Public Health 40: 963971.
  25. Berlioz-Arthaud A, Guillard B, Goarant C, Hem S, , 2010. Hospital-based active surveillance of human leptospirosis in Cambodia. Bull Soc Pathol Exot 103: 111118.[Crossref]
  26. Laras K, Cao BV, Bounlu K, Nguyen TK, Olson JG, Thongchanh S, Tran NV, Hoang KL, Punjabi N, Ha BK, Ung SA, Insisiengmay S, Watts DM, Beecham HJ, Corwin AL, , 2002. The importance of leptospirosis in southeast Asia. Am J Trop Med Hyg 67: 278286.
  27. Blacksell SD, Smythe L, Phetsouvanh R, Dohnt M, Hartskeerl R, Symonds M, Slack A, Vongsouvath M, Davong V, Lattana O, Phongmany S, Keolouangkot V, White NJ, Day NP, Newton PN, , 2006. Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in Laos. Clin Vaccine Immunol 13: 11661169.[Crossref]
  28. Henttonen H, Buchy P, Suputtamongkol Y, Jittapalapong S, Herbreteau V, Laakkonen J, Chaval Y, Galan M, Dobigny G, Charbonnel N, Michaux J, Cosson JF, Morand S, Hugot JP, , 2008. Recent discoveries of new hantaviruses widen their range and question their origins. Ann N Y Acad Sci 1149: 8489.[Crossref]
  29. Reynes JM, Soares JL, Hue T, Bouloy M, Sun S, Kruy SL, Flye Sainte Marie F, Zeller H, , 2003. Evidence of the presence of Seoul virus in Cambodia. Microbes Infect 5: 769773.[Crossref]
  30. Lin JN, Lai CH, Chen YH, Lin HL, Huang CK, Chen WF, Wang JL, Chung HC, Liang SH, Lin HH, , 2010. Sphingomonas paucimobilis bacteremia in humans: 16 case reports and a literature review. J Microbiol Immunol Infect 43: 3542.[Crossref]
  31. Lopez Rodriguez E, Tomashek KM, Gregory CJ, Munoz J, Hunsperger E, Lorenzi OD, Irizarry JG, Garcia-Gubern C, , 2010. Co-infection with dengue virus and pandemic (H1N1) 2009 virus. Emerg Infect Dis 16: 882884.[Crossref]
  32. Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, Suwancharoen D, Panlar P, Saisongkorh W, Rolain JM, Raoult D, Suputtamongkol Y, , 2006. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Ann Trop Med Parasitol 100: 363370.[Crossref]
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  • Received : 24 Jun 2011
  • Accepted : 14 Oct 2011

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