1921
Volume 86, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The performance of two histidine-rich protein type-2–based malaria rapid diagnostic tests (mRDTs) was examined in a rural area with a high prevalence of malaria and human immunodeficiency virus type-1 (HIV-1) infection in 113 and 445 febrile patients ≥ 15 years of age with and without HIV-1 infection, respectively. Patients were tested for HIV-1 infection by using a standard assay and for by using two mRDTs and microscopy. When microscopy was used as the gold standard, both mRDTs performed similarly in patients with and without HIV-1 infection: Bioline SD Malaria Antigen P.f, sensitivity 94.4% (95% confidence interval [CI]: 81.3–99.3%) versus 97.1% (95% CI:92.8–99.2%) and specificity 50.6% (95% CI: 39.0–62.2%) versus 47.2% (95% CI: 41.4–53.1%); and ICT diagnostics Malaria Pf, sensitivity 94.4% (95% CI: 81.3–99.3%) versus 97.1% (95% CI: 92.8–99.2%) and specificity 50.6% (95% CI:39.0–62.2%) versus 50.3% (95% CI: 44.4–56.1%). Infection with HIV-1 does not appear to affect the performance of these histidine-rich protein type-2 (HRP-2)-based mRDTs.

[open-access] Freely available online through the Open Access option.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2012.11-0350
2012-02-01
2019-07-21
Loading full text...

Full text loading...

/deliver/fulltext/14761645/86/2/199.html?itemId=/content/journals/10.4269/ajtmh.2012.11-0350&mimeType=html&fmt=ahah

References

  1. World Health Organization, 2010. World Malaria Report. Geneva: World Health Organization. [Google Scholar]
  2. Joint United Nations Program on HIV/AIDS (UNAIDS), 2010. Global Report: UNAIDS Report on the Global AIDS Epidemic. New York: United Nations. [Google Scholar]
  3. Hewitt K, Steketee R, Mwapasa V, Whitworth J, French N, , 2006. Interactions between HIV and malaria in non-pregnant adults: evidence and implications. AIDS 20: 19932004.[Crossref] [Google Scholar]
  4. Quigley MA, Hewitt K, Mayanja B, Morgan D, Eotu H, Ojwiya A, Whitworth JA, , 2005. The effect of malaria on mortality in a cohort of HIV-infected Ugandan adults. Trop Med Int Health 10: 894900.[Crossref] [Google Scholar]
  5. Whitworth J, Morgan D, Quigley M, Smith A, Mayanja B, Eotu H, Omoding N, Okongo M, Malamba S, Ojwiya A, , 2000. Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet 356: 10511056.[Crossref] [Google Scholar]
  6. Whitworth JA, Hewitt KA, , 2005. Effect of malaria on HIV-1 progression and transmission. Lancet 365: 196197.[Crossref] [Google Scholar]
  7. Laufer MK, van Oosterhout JJ, Thesing PC, Dzinjalamala FK, Hsi T, Beraho L, Graham SM, Taylor TE, Plowe CV, , 2007. Malaria treatment efficacy among people living with HIV: the role of host and parasite factors. Am J Trop Med Hyg 77: 627632. [Google Scholar]
  8. Laufer MK, van Oosterhout JJ, Thesing PC, Thumba F, Zijlstra EE, Graham SM, Taylor TE, Plowe CV, , 2006. Impact of HIV-associated immunosuppression on malaria infection and disease in Malawi. J Infect Dis 193: 872878.[Crossref] [Google Scholar]
  9. National Statistical Office (NSO) Malawi, 2005. ORC Macro: Malawi Demographic and Health Survey 2004. Calverton, MD: NSO and ORC Macro. [Google Scholar]
  10. French N, Nakiyingi J, Lugada E, Watera C, Whitworth JA, Gilks CF, , 2001. Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults. AIDS 15: 899906.[Crossref] [Google Scholar]
  11. Patnaik P, Jere CS, Miller WC, Hoffman IF, Wirima J, Pendame R, Meshnick SR, Taylor TE, Molyneux ME, Kublin JG, , 2005. Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural Malawi. J Infect Dis 192: 984991.[Crossref] [Google Scholar]
  12. Coleman PG, Morel C, Shillcutt S, Goodman C, Mills AJ, , 2004. A threshold analysis of the cost-effectiveness of combination therapies in sub-saharan Africa. Am J Trop Med Hyg 71 (Suppl) 196204. [Google Scholar]
  13. World Health Organization, 2010. Guidelines for the Treatment of Malaria. Second edition. Geneva: World Health Organization. [Google Scholar]
  14. Van Geertruyden JP, Menten J, Colebunders R, Korenromp E, D’Alessandro U, , 2008. The impact of HIV-1 on the malaria parasite biomass in adults in sub-Saharan Africa contributes to the emergence of antimalarial drug resistance. Malar J 7: 134.[Crossref] [Google Scholar]
  15. Murray CK, Gasser RA, Jr Magill AJ, Miller RS, , 2008. Update on rapid diagnostic testing for malaria. Clin Microbiol Rev 21: 97110.[Crossref] [Google Scholar]
  16. Wongsrichanalai C, Barcus MJ, Muth S, Sutamihardja A, Wernsdorfer WH, , 2007. A review of malaria diagnostic tools: microscopy and rapid diagnostic test (RDT). Am J Trop Med Hyg 77 (Suppl) 119127. [Google Scholar]
  17. World Health Organization, 2004. Malaria and HIV Interactions and their Implications for Public Health Policy. WHO Technical Consultation on Malaria and HIV Interactions and Public Health Policy Implications. Geneva: World Health Organization. [Google Scholar]
  18. World Health Organization, 2004. The Role of Laboratory Diagnosis to Support Malaria Disease Management. Focus on the Use of Rapid Diagnostic Tests in Areas of High Transmission. Report of a WHO Technical Consultation. Geneva: World Health Organization. [Google Scholar]
  19. Berg A, Patel S, Langeland N, Blomberg B, , 2008. Falciparum malaria and HIV-1 in hospitalized adults in Maputo, Mozambique: does HIV-infection obscure the malaria diagnosis? Malar J 7: 252.[Crossref] [Google Scholar]
  20. Mills LA, Kagaayi J, Nakigozi G, Galiwango RM, Ouma J, Shott JP, Ssempijja V, Gray RH, Wawer MJ, Serwadda D, Quinn TC, Reymolds SJ, , 2010. Utility of a point-of-care malaria rapid diagnostic test for excluding malaria as the cause of fever among HIV-positive adults in rural Rakai, Uganda. Am J Trop Med Hyg 82: 145147.[Crossref] [Google Scholar]
  21. Chinkhumba J, Skarbinski J, Chilima B, Campbell C, Ewing V, San Joaquin M, Sande J, Ali D, Mathanga D, , 2010. Comparative field performance and adherence to test results of four malaria rapid diagnostic tests among febrile patients more than five years of age in Blantyre, Malawi. Malar J 9: 209. [Google Scholar]
  22. Swarthout TD, Counihan H, Senga RK, van den Broek I, , 2007. Paracheck-Pf accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis? Malar J 6: 58.[Crossref] [Google Scholar]
  23. McMorrow ML, Masanja MI, Kahigwa E, Abdulla SM, Kachur SP, , 2010. Quality assurance of rapid diagnostic tests for malaria in routine patient care in rural Tanzania. Am J Trop Med Hyg 82: 151155.[Crossref] [Google Scholar]
  24. Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G, , 2008. Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis 197: 510518.[Crossref] [Google Scholar]
  25. Eni RN, Ogbechie PO, Ibrahim A, , 2005. Prevalence of malaria among HIV/AIDS patients at Ahmadu Bello University teaching hospital, Kaduna, Nigeria. Ann Afr Med 4: 43. [Google Scholar]
  26. Kirkwood BR, Sterne JA, , 2003. Essential Medical Dtatistics. Second edition. Malden, MA: Blackwell Science. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2012.11-0350
Loading
/content/journals/10.4269/ajtmh.2012.11-0350
Loading

Data & Media loading...

  • Received : 03 Jun 2011
  • Accepted : 01 Nov 2011
  • Published online : 01 Feb 2012

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error